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ZYBT1 , CAS No.Z614995, Inhibitor of BMX non-receptor tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of tec protein tyrosine kinase

  • Moligand™
Item Number
Z614995
Grouped product items
SKUSizeAvailabilityPrice Qty
Z614995-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$600.90
Z614995-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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BMX non-receptor tyrosine kinase Inhibitor Bruton tyrosine kinase Inhibitor tec protein tyrosine kinase Inhibitor

Basic Description

Synonymsexample 13 [WO2015132799A2]
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of BMX non-receptor tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of tec protein tyrosine kinase

Associated Targets

TEC Tchem Tyrosine-protein kinase Tec 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BMX Tchem Cytoplasmic tyrosine-protein kinase BMX 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[4-amino-1-(2-prop-2-enoyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl)pyrazolo[3,4-d]pyrimidin-3-yl]-N-pyridin-2-ylbenzamide
INCHI InChI=1S/C27H26N8O2/c1-2-22(36)34-13-18-11-20(12-19(18)14-34)35-26-23(25(28)30-15-31-26)24(33-35)16-6-8-17(9-7-16)27(37)32-21-5-3-4-10-29-21/h2-10,15,18-20H,1,11-14H2,(H2,28,30,31)(H,29,32,37)
InChi Key YMCOZPHXLROTBV-UHFFFAOYSA-N
Canonical SMILES C=CC(=O)N1CC2C(C1)CC(C2)n1nc(c2c1ncnc2N)c1ccc(cc1)C(=O)Nc1ccccn1
Isomeric SMILES C=CC(=O)N1CC2CC(CC2C1)N3C4=NC=NC(=C4C(=N3)C5=CC=C(C=C5)C(=O)NC6=CC=CC=N6)N
PubChem CID 118356682

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Ghoshdastidar K, Patel H, Bhayani H, Patel A, Thakkar K, Patel D, Sharma M, Singh J, Mohapatra J, Chatterjee A et al..  (2020)  ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer..  Pharmacol Res Perspect,  8  (4): (e00565).  [PMID:32790160]

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