ZYF0033 , CAS No.2380300-79-6

Item Number

Z650142

Grouped product items
SKU	Size	Availability	Price
Z650142-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$129.90
Z650142-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$323.90
Z650142-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$549.90
Z650142-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,153.90
Z650142-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,960.90
Z650142-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,333.90

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Basic Description

Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	ZYF0033 (HPK1-IN-22, compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC 50 less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 decreases the phosphorylation of SLP76 (serine 376). ZYF0033 promotes anticancer immune responses. ZYF0033 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a + CD8 + T cells but decreased infiltration of regulatory T cells, PD-1 + CD8 + T cells, TIM-3 + CD8 + T cells, and LAG3 + CD8 + T cells in the 4T-1 syngeneic mouse model IC50& Target:HPK1 <10 nM (IC 50 )

Canonical SMILES

OC(C)(C)C#CC1=CC=CC(COC2=C(N)N=CC(C3=CN=C(C4CCN(CC4)C)S3)=C2)=C1

Molecular Weight

462.61

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Basic Description