Basic Description

Synonyms	1,2,3,4-Tetrahydro-1-naphthol \| 529-33-9 \| 1,2,3,4-Tetrahydronaphthalen-1-ol \| Tetralin-1-ol \| 1-Tetralol \| alpha-Tetralol \| 1-Hydroxytetralin \| 1-Naphthalenol, 1,2,3,4-tetrahydro- \| .alpha.-Tetralol \| NSC 5172 \| 1-NAPHTHOL, 1,2,3,4-TETRAHYDRO- \| Tetrahydro-1-naphthol \| DTXSID70
Specifications & Purity	≥95%(GC)
Shipped In	Normal
Product Description	(R)-(-)-enantiomer of 1,2,3,4-Tetrahydro-1-naphthol is a substrate for aryl sulfotransferase (AST) IV enzyme and (S)-(+)-1,2,3,4-tetrahydro-1-naphthol is a competitive inhibitor of AST IV-catalyzed sulfation of 1-naphthalenemethanol[1]. It is the major urinary metabolite of tetralin[2]. 1,2,3,4-Tetrahydro-1-naphthol was used as chiral probe to examine the role of three aromatic residues in enzyme-substrate interactions at the sulfuryl acceptor binding site of aryl sulfotransferase IV enzyme[3].

Associated Targets(Human)

SULT1A1 Tchem Sulfotransferase 1A1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (221 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sult1a1 Aryl sulfotransferase (136 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pubchem Sid	488181173
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488181173
IUPAC Name	1,2,3,4-tetrahydronaphthalen-1-ol
INCHI	InChI=1S/C10H12O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10-11H,3,5,7H2
InChi Key	JAAJQSRLGAYGKZ-UHFFFAOYSA-N
Canonical SMILES	C1CC(C2=CC=CC=C2C1)O
Isomeric SMILES	C1CC(C2=CC=CC=C2C1)O
WGK Germany	3
RTECS	QL5075000
PubChem CID	10723
Molecular Weight	148.21
Beilstein	2046230
Reaxy-Rn	2046227

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Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	3
RTECS	QL5075000
Reaxy-Rn	2046227

1. Jonathan J Sheng, Atmaja Saxena, Michael W Duffel,. (2004-04-22) Influence of phenylalanines 77 and 138 on the stereospecificity of aryl sulfotransferase IV.. Drug metabolism and disposition: the biological fate of chemicals, 32 ((5)): ( 559-565 ). [PMID:15100179]

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SKU	Size	Availability	Price
T161537-1g	1g	In stock	$9.90
T161537-5g	5g	In stock	$36.90
T161537-10g	10g	In stock	$64.90
T161537-25g	25g	In stock	$105.90
T161537-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$379.90