Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T588719-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $33.90 | |
T588719-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $104.90 | |
T588719-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $464.90 |
Synonyms | Acridine, 9-amino-1,2,3,4-tetrahydro- | KBioGR_001337 | NCGC00015054-06 | SY138494 | Tetrahydroaminoacridine | Acridine, 1,2,3,4-tetrahydro-9-amino- | AKOS000277493 | BPBio1_000371 | KBio3_002518 | 2aox | BIDD:GT0090 | SDCCGSBI-0050025.P004 | 1,2,3,4-tetr |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged,Desiccated |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR, INHIBITOR |
Mechanism of action | Inhibitor of acetylcholinesterase (Cartwright blood group);Inhibitor of butyrylcholinesterase;Allosteric modulator of M 1 receptor;Allosteric modulator of M 2 receptor |
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IUPAC Name | 1,2,3,4-tetrahydroacridin-9-amine |
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INCHI | InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) |
InChi Key | YLJREFDVOIBQDA-UHFFFAOYSA-N |
Canonical SMILES | C1CCC2=NC3=CC=CC=C3C(=C2C1)N |
Isomeric SMILES | C1CCC2=NC3=CC=CC=C3C(=C2C1)N |
PubChem CID | 1935 |
Molecular Weight | 198.26 |
CAS Registry No. | 321-64-2 |
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PubChem CID | 1935 |
ChEMBL Ligand | CHEMBL95 |
ChEBI | CHEBI:45980 |
DrugBank Ligand | DB00382 |
Wikipedia | Tacrine |
RCSB PDB Ligand | THA |
Reactome Reaction | R-HSA-9634834 |
Reactome Drug | R-ALL-9635024 |
DrugCentral Ligand | 2551 |
GPCRdb Ligand | tacrine |
Enter Lot Number to search for COA:
Sensitivity | light and moisture and air sensitive |
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Melt Point(°C) | 183℃ |
Pictogram(s) | GHS06, GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled H351:Suspected of causing cancer |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
1. Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li. (2024) Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 264 (12): (116013). [PMID:38052155] |
2. Yang Mao-Hui, Zhou Xin, Yang Yan, Chen Hua-Guo. (2023) Effects of different extraction methods on the structural characterization and bioactivities of polysaccharides extracted from Polygonatum sibiricum. Journal of Food Measurement and Characterization, (30): (1-15). [PMID:28733330] |
3. Chen Tingting, Qin Yingfeng, Wang Beibei, Lai Rongji, Tan Guohe, Liu Jin-Wen. (2023) Enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets for sensitive fluorescence detection of acetylcholinesterase activity and inhibition. MICROCHIMICA ACTA, 190 (7): (1-10). [PMID:37338607] |
4. Yao H, Uras G, Zhang P, Xu S, Yin Y, Liu J, Qin S, Li X, Allen S, Bai R, Gong Q, Zhang H, Zhu Z, Xu J.. (2021) Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.. J Med Chem, 64 (11.0): (7483-7506). [PMID:34024109] |
1. Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li. (2024) Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 264 (12): (116013). [PMID:38052155] |
2. Yang Mao-Hui, Zhou Xin, Yang Yan, Chen Hua-Guo. (2023) Effects of different extraction methods on the structural characterization and bioactivities of polysaccharides extracted from Polygonatum sibiricum. Journal of Food Measurement and Characterization, (30): (1-15). [PMID:28733330] |
3. Chen Tingting, Qin Yingfeng, Wang Beibei, Lai Rongji, Tan Guohe, Liu Jin-Wen. (2023) Enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets for sensitive fluorescence detection of acetylcholinesterase activity and inhibition. MICROCHIMICA ACTA, 190 (7): (1-10). [PMID:37338607] |
4. Yao H, Uras G, Zhang P, Xu S, Yin Y, Liu J, Qin S, Li X, Allen S, Bai R, Gong Q, Zhang H, Zhu Z, Xu J.. (2021) Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.. J Med Chem, 64 (11.0): (7483-7506). [PMID:34024109] |