Grouped product items

SKU

Size

Availability

Price

Qty

T487139-100mg

100mg

Available within 8-12 weeks(?)

$182.90

Basic Description

Synonyms	5470-37-1 \| Tetrahydroharman-3-carboxylic acid \| 1-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid \| 1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid \| 1,2,3,4-tetrahydroharman-3-carboxylic acid \| 1H-Pyrido[3,4-b]indole-3-carboxyli
Biochemical and Physiological Mechanisms	Implicated in eosinophilia-myalgia syndrome associated with L-tryptophan ingestion.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Description Reactant involved in synthesis of molecules for biological studies including:Cytotoxicity and insecticidal activities of harmine derivativesIsoquinolines, β-carbolines, and 3-deazapurines via oxidative decarboxylationCytotoxic evaluation of 1,3-di- and 1,3,9-trisubstituted β-carbolines

Associated Targets(Human)

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 (0 Activities)

Discover Target: PTPN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

Discover Target: Ptpn1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus subtilis (32866 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Amorphotheca resinae (75 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human alphaherpesvirus 1 (11089 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Poliovirus 1 (1274 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388 (20296 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Culex quinquefasciatus (137 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trichophyton mentagrophytes (4846 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lipaphis erysimi (85 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
INCHI	InChI=1S/C13H14N2O2/c1-7-12-9(6-11(14-7)13(16)17)8-4-2-3-5-10(8)15-12/h2-5,7,11,14-15H,6H2,1H3,(H,16,17)
InChi Key	ZUPHXNBLQCSEIA-UHFFFAOYSA-N
Canonical SMILES	CC1C2=C(CC(N1)C(=O)O)C3=CC=CC=C3N2
Isomeric SMILES	CC1C2=C(CC(N1)C(=O)O)C3=CC=CC=C3N2
PubChem CID	73530
Molecular Weight	230.27

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. E Papavergou,M N Clifford. (1992-01-01) Tetrahydro-beta-carboline carboxylic acids in smoked foods.. Food additives and contaminants, 9 ((1)): (83-95). [PMID:1397393]
2. Y Yamaguchi,J Tsunoda,T Suda,Y Miura,K Shioiri-Nakano,T Kasahara. (1991-08-15) Effect of synthesized constituents in the L-tryptophan product on the differentiation of eosinophils and the induction of IL-6: a possible cause of eosinophilia-myalgia syndrome.. Biochemical and biophysical research communications, 178 ((3)): (1008-1013). [PMID:1872826]
3. J Adachi,K Yamamoto,Y Ogawa,Y Ueno,Y Mizoi,Y Tatsuno. (1991-01-01) Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan.. Archives of toxicology, 65 ((6)): (505-509). [PMID:1929872]
4. . (1990-10-03) From the Centers for Disease Control. Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome.. JAMA, 264 ((13)): (1656-1656). [PMID:2169007]
5. K Fujie,J Nishi,M Wada,S Maeda,T Sugiyama. (1990-04-01) Acute cytogenetic effects of tyramine, MTCAs, NaCl and soy sauce on rat bone marrow cells in vivo.. Mutation research, 240 ((4)): (281-288). [PMID:2330012]
6. D E Brenneman,S W Page,M Schultzberg,F S Thomas,P Zelazowski,P Burnet,R Avidor,E M Sternberg. (1993-08-01) A decomposition product of a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome affects spinal cord neuronal cell death and survival through stereospecific, maturation and partly interleukin-1-dependent mechanisms.. The Journal of pharmacology and experimental therapeutics, 266 ((2)): (1029-1035). [PMID:8355179]
7. J Adachi,Y Ueno,Y Ogawa,S Hishida,K Yamamoto,H Ouchi,Y Tatsuno. (1993-02-24) Acetaldehyde-induced formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in rats.. Biochemical pharmacology, 45 ((4)): (935-941). [PMID:8452569]
8. J Adachi,T Naito,Y Ueno,Y Ogawa,I Ninomiya,Y Tatsuno. (1993-01-01) Metabolism and distribution in the rat of peak E substance, a constituent in L-tryptophan product implicated in eosinophilia-myalgia syndrome.. Archives of toxicology, 67 ((4)): (284-289). [PMID:8517785]
9. V Bantseev,R Bhardwaj,W Rathbun,H Nagasawa,J R Trevithick. (1997-09-26) Antioxidants and cataract: (cataract induction in space environment and application to terrestrial aging cataract).. Biochemistry and molecular biology international, 42 ((6)): (1189-1197). [PMID:9305537]
10. N Arutselvan,S Gopalan,V G Kulkarni,K Balakrishna. (1999-10-09) Antioxidative activity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid.. Arzneimittel-Forschung, 49 ((9)): (729-731). [PMID:10514898]
11. H Tsuchiya,M Sato,I Watanabe. (1999-12-10) Antiplatelet activity of soy sauce as functional seasoning.. Journal of agricultural and food chemistry, 47 ((10)): (4167-4174). [PMID:10552785]
12. T Herraiz. (1999-12-22) 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid and 1,2, 3,4-tetrahydro-beta-carboline-3-carboxylic acid in fruits.. Journal of agricultural and food chemistry, 47 ((12)): (4883-4887). [PMID:10606547]
13. Shu-Mei Lin,Jin-Yi Wu,Chien Su,Sophia Ferng,Chih-Yu Lo,Robin Y-Y Chiou. (2012-09-11) Identification and mode of action of 5-hydroxymethyl-2-furfural (5-hmf) and 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) as potent xanthine oxidase inhibitors in vinegars.. Journal of agricultural and food chemistry, 60 ((39)): (9856-9862). [PMID:22957895]
14. A Nagahara,S Kumagai. (1991-04-01) Excretion and distribution of nitrite-treated or untreated 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in rats.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 29 ((4)): (243-247). [PMID:2040486]
15. . (1990-08-31) Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome.. MMWR. Morbidity and mortality weekly report, 39 ((34)): (589-591). [PMID:2166897]
16. H Tsuchiya,S Ohtani,K Yamada,N Takagi,H Todoriki,T Hayashi. (1994-03-01) Quantitation of urinary 1,2,3,4-tetrahydro-beta-carboline and 1-methyl-1,2,3,4-tetrahydro-beta-carboline by high-performance liquid chromatography.. Journal of pharmaceutical sciences, 83 ((3)): (415-418). [PMID:8207693]
17. Y Ogawa,J Adachi,Y Tatsuno. (1993-01-01) Accumulation of 1-methyl-tetrahydro-beta-carboline-3-carboxylic acid in blood and organs of rat. A possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan.. Archives of toxicology, 67 ((4)): (290-293). [PMID:8517786]
18. M Higashimoto,T Yamamoto,T Kinouchi,H Matsumoto,Y Ohnishi. (1996-01-01) Mutagenicity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid treated with nitrite in the presence of alcohols.. Mutation research, 367 ((1)): (43-49). [PMID:8596545]
19. J Adachi,Y Ueno,Y Tatsuno,M Gomez,C C Smith,E M Sternberg. (1996-01-01) A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome.. Advances in experimental medicine and biology, 398 (365-370). [PMID:8906290]
20. S Manabe,J Yuan,T Takahashi,R C Urban. (1996-08-01) Age-related accumulation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in human lens.. Experimental eye research, 63 ((2)): (179-186). [PMID:8983975]
21. B Gutsche,M Herderich. (1997-04-11) High-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry for the analysis of 1,2,3,4-tetrahydro-beta-carboline derivatives.. Journal of chromatography. A, 767 ((1-2)): (101-106). [PMID:9177007]
22. T Herraiz. (2000-12-05) Tetrahydro-beta-carboline-3-carboxylic acid compounds in fish and meat: possible precursors of co-mutagenic beta-carbolines norharman and harman in cooked foods.. Food additives and contaminants, 17 ((10)): (859-866). [PMID:11103270]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

1,2,3,4-Tetrahydroharmane-3-carboxylic acid , CAS No.5470-37-1