1,2-Dioctanoyl-sn-glycerol - 95%, high purity , CAS No.60514-48-9

Item Number

S359043

• Synonyms: 1,2-dioctanoyl-sn-glycerol | 60514-48-9 | sn-1,2-Dioctanoylglycerol | Dicaprylglyceride | (S)-3-Hydroxypropane-1,2-diyl dioctanoate | 1,2-Dicapryloyl-sn-glycerol | D-alpha,beta-Dicaprylin | [(2S)-3-hydroxy-2-octanoyloxypropyl] octanoate | CHEMBL55267 | CHEBI:76979 | Octanoic
• Specifications & Purity: Moligand™, ≥95%
• Biochemical and Physiological Mechanisms: Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

1,2-Dioctanoyl-sn-glycerol is a cell-permeable activator of PKC (protein kinase C). Exhibits lower affinity for PKCa than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.
To study its stimulatory effect on protein kinase C (PKC) in human cell lines
As a lipid cofactor in PKC activity assay
In vesicular-fusion protein Sec-18 binding studies