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1,2-Dioleoyl-3-trimethylammonium-propane, Chloride - 99%, high purity , CAS No.132172-61-3
Basic Description Synonyms DOTAP | Dotap chloride | (+/-)-Dotap chloride | DOTAP (chloride) | Dotap chloride, (+/-)- | 1,2-Dioleoyl-3-trimethylammonium-propane, Chloride | 1-Propanaminium, N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-, chloride (1:1) Specifications & Purity ≥99% Biochemical and Physiological Mechanisms 1,2-Dioleyloxy-3-(trimethylammonium)propane (DOTAP) chloride can be used to prepare liposomes without the use of cophospholipids. DOTAP chloride is soluble in dimethyl sulfoxide (DMSO) and ethanol, thereby clarifying its role as a transfection reagent. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description 1,2-Dioleoyl-3-trimethylammonium-propane, Chloride is a a cationic lipid used for the transfecting of negatively charged molecules into eurkaryotic cells.
Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride INCHI InChI=1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-; InChi Key KSXTUUUQYQYKCR-LQDDAWAPSA-M Canonical SMILES CCCCCCCCC=CCCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC.[Cl-] Isomeric SMILES CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-] PubChem CID 11636182 Molecular Weight 698.54
Chemical and Physical Properties Solubility Soluble in Chloroform and Dichloromethane Sensitivity Moisture sensitive.
Citations of This Product 1. Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu. (2022) A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma. Biomaterials Science, 10 (23): (6791-6803). [PMID:36314541 ] [10.1039/D2BM01145J ]
References 1. Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu. (2022) A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma. Biomaterials Science, 10 (23): (6791-6803). [PMID:36314541 ] [10.1039/D2BM01145J ]
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