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1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) - 98%, high purity , CAS No.132172-61-3
Basic Description Synonyms N-(2,3-Dioleoyloxy)propyl-N,N,N-trimethylammonium Chloride | Dotap chloride | N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium chloride | N,N,N-Trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium Chloride Specifications & Purity ≥98% Biochemical and Physiological Mechanisms DOTAP chloride can be used to prepare liposomes without the use of auxiliary phospholipids. DOTAP chloride is soluble in dimethyl sulfoxide (DMSO) and ethanol, which can clarify its role as a transfection reagent.
Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads
Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride INCHI InChI=1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-; InChi Key KSXTUUUQYQYKCR-LQDDAWAPSA-M Canonical SMILES CCCCCCCCC=CCCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC.[Cl-] Isomeric SMILES CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-] PubChem CID 11636182 Molecular Weight 698.54
Chemical and Physical Properties Sensitivity Heat and moisture sensitive
Citations of This Product 1. Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu. (2022) A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma. Biomaterials Science, 10 (23): (6791-6803). [PMID:36314541 ] [10.1039/D2BM01145J ]
References 1. Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu. (2022) A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma. Biomaterials Science, 10 (23): (6791-6803). [PMID:36314541 ] [10.1039/D2BM01145J ]
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H2427495
