1,2-Naphthoquinone - 95%, high purity , CAS No.524-42-5

  • ≥95%
Item Number
N113473
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SKUSizeAvailabilityPrice Qty
N113473-200mg
200mg
Available within 8-12 weeks(?)
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$9.90
N113473-250mg
250mg
In stock
$9.90
N113473-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$26.90
N113473-5g
5g
In stock
$101.90
N113473-25g
25g
In stock
$457.90
View related series
Carbonyl compound ketone

Basic Description

SynonymsBBL027354 | 1,2-Naphthalenedione | HSDB 2036 | NAPHTHOQUINONE, 1,2- | 1,2-Dihydro-1,2-diketo-naphthalene | F30116 | 1,2-NAPHTHOQUINONE | AM85414 | BRN 0606546 | Z324553598 | DTXSID2060171 | 1,2-Naphthaquinone | 1,2-NAPHTHOQUINONE [MI] | 4-07-00-02417 (Bei
Specifications & Purity≥95%
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
Product Description

product description:

1,2-Naphthoquinone is one of the major metabolite of naphthalene, which is responsible for the cytotoxicity and genotoxicity associated with it. 1,2-Naphthoquinone is an atmospheric contaminant. It causes the contraction of trachea smooth muscles in guinea pig through the activation of epidermal growth factor receptor. 1,2-Naphthoquinone has been reported as an environmental quinone in diesel exhaust particles (DEP) and atmospheric particulate matter.


application:

1,2-Naphthoquinone was employed as mediator during electrochemical mapping of redox activity in normal human breast (MCF-10A) cells by scanning electrochemical microscopy (SECM).

Associated Targets(Human)

CES1 Tchem Liver carboxylesterase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CES1 Tchem Acyl coenzyme A:cholesterol acyltransferase (1029 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPRC Tchem Leukocyte common antigen (2317 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN22 Tchem Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP (1215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
microRNA 21 (64692 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

tat Human immunodeficiency virus type 1 Tat protein (75 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Papain (844 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
protease Human rhinovirus A protease (1343 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichoplusia ni (986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dnaB Replicative DNA helicase (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TGR Thioredoxin glutathione reductase (28579 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
recA Protein RecA (2211 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name naphthalene-1,2-dione
INCHI InChI=1S/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H
InChi Key KETQAJRQOHHATG-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C=CC(=O)C2=O
Isomeric SMILES C1=CC=C2C(=C1)C=CC(=O)C2=O
WGK Germany 3
RTECS QL7000000
PubChem CID 10667
UN Number 2811
Packing Group I
Molecular Weight 158.15
Beilstein 606546
Reaxy-Rn 606546

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
K2405398Certificate of AnalysisJul 11, 2024 N113473
B2323578Certificate of AnalysisDec 14, 2021 N113473
F2309040Certificate of AnalysisDec 14, 2021 N113473
K2406180Certificate of AnalysisDec 14, 2021 N113473

Chemical and Physical Properties

SolubilityChloroform (Slightly), DMSO (Slightly)
SensitivitySensitive to heat, air, and light
Melt Point(°C)139-142 °C (dec.) (lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS QL7000000
Reaxy-Rn 606546
Class 6.1
Merck Index 6394

Related Documents

Citations of This Product

1. Shuyan Zang,Bin Lian,Juan Wang,Yanjie Yang.  (2010-07-09)  Biodegradation of 2-naphthol and its metabolites by coupling Aspergillus niger with Bacillus subtilis..  Journal of environmental sciences (China),  22  ((5)): (669-674).  [PMID:20608501]
2. Junqi Liu, Meng Wang, Saijin Wang, Yanli Zhao, Shi Zhou, Jinlian Li, Dongmei Wu.  (2024)  Assessment of oxygenated polycyclic aromatic hydrocarbon cytotoxicity using TiO2-MXene/MWCNTs/PDA/GCE electrochemical sensor.  ELECTROCHIMICA ACTA,  474  (8): (143515).  [PMID:9873016] [10.1016/j.electacta.2023.143515]
3. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang.  (2023)  “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process.  ACS Nano,  17  (18): (18227–18239).  [PMID:37668306] [10.1021/acsnano.3c05229]
4. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang.  (2023)  Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl.  ANALYTICAL CHEMISTRY,  95  (8): (4015–4023).  [PMID:36802553] [10.1021/acs.analchem.2c04373]

References

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16. Yasuhiro Shinkai,Noriko Iwamoto,Takashi Miura,Takeshi Ishii,Arthur K Cho,Yoshito Kumagai.  (2012-05-17)  Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35 causes inhibition of its catalytic activity and activation of ASK1/p38 signaling..  Chemical research in toxicology,  25  ((6)): (1222-1230).  [PMID:22587396]
17. Payal Pahwa,Manju Papreja.  (2012-05-19)  Cheminformatics based 3D-QSAR study on a series of 1,2-naphthoquinone derivatives as PTP 1B inhibitors..  Acta poloniae pharmaceutica,  69  ((3)): (535-543).  [PMID:22594268]
18. Safwan Ashour,Roula Bayram.  (2012-10-09)  Novel spectrophotometric method for determination of some macrolide antibiotics in pharmaceutical formulations using 1,2-naphthoquinone-4-sulphonate..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  99  (74-80).  [PMID:23041925]
19. Yoshinari Sawama,Yuko Shishido,Takayoshi Yanase,Koichi Kawamoto,Ryota Goto,Yasunari Monguchi,Yasuyuki Kita,Hironao Sajiki.  (2012-12-21)  Efficient generation of ortho-naphthoquinone methides from 1,4-epoxy-1,4-dihydronaphthalenes and their annulation with allyl silanes..  Angewandte Chemie (International ed. in English),  52  ((5)): (1515-1519).  [PMID:23255488]
20. Takashi Toyama,Yasuhiro Shinkai,Aki Yazawa,Hidenao Kakehashi,Toshiyuki Kaji,Yoshito Kumagai.  (2014-03-04)  Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4..  Chemico-biological interactions,  214  (41-48).  [PMID:24582816]
21. Jan Hintzpeter,Hans-Joerg Martin,Edmund Maser.  (2014-11-08)  Reduction of lipid peroxidation products and advanced glycation end-product precursors by cyanobacterial aldo-keto reductase AKR3G1—a founding member of the AKR3G subfamily..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology,  29  ((1)): (263-273).  [PMID:25376835]
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28. Akiko Endo,Daigo Sumi,Yoshito Kumagai.  (2007-07-31)  1,2-Naphthoquinone disrupts the function of cAMP response element-binding protein through covalent modification..  Biochemical and biophysical research communications,  361  ((1)): (243-248).  [PMID:17658470]
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31. Shuyan Zang,Bin Lian,Juan Wang,Yanjie Yang.  (2010-07-09)  Biodegradation of 2-naphthol and its metabolites by coupling Aspergillus niger with Bacillus subtilis..  Journal of environmental sciences (China),  22  ((5)): (669-674).  [PMID:20608501]
32. Takashi Miura,Yoshito Kumagai.  (2010-12-09)  Immunochemical method to detect proteins that undergo selective modification by 1,2-naphthoquinone derived from naphthalene through metabolic activation..  The Journal of toxicological sciences,  35  ((6)): (843-852).  [PMID:21139334]
33. Akiko Endo,Daigo Sumi,Noriko Iwamoto,Yoshito Kumagai.  (2011-05-03)  Inhibition of DNA binding activity of cAMP response element-binding protein by 1,2-naphthoquinone through chemical modification of Cys-286..  Chemico-biological interactions,  192  ((3)): (272-277).  [PMID:21530497]
34. Chao-Jian Chen,Gong-Yan Liu,Ye-Ting Shi,Cong-Shan Zhu,Shao-Peng Pang,Xiang-Sheng Liu,Jian Ji.  (2011-06-16)  Biocompatible micelles based on comb-like PEG derivates: formation, characterization, and photo-responsiveness..  Macromolecular rapid communications,  32  ((14)): (1077-1081).  [PMID:21674666]
35. Wan-Yun Cheng,Jenna Currier,Philip A Bromberg,Robert Silbajoris,Steven O Simmons,James M Samet.  (2011-10-15)  Linking oxidative events to inflammatory and adaptive gene expression induced by exposure to an organic particulate matter component..  Environmental health perspectives,  120  ((2)): (267-274).  [PMID:21997482]
36. Robert F Jacob,Michael D Aleo,Yehudi Self-Medlin,Colleen M Doshna,R Preston Mason.  (2013-10-17)  1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes..  Investigative ophthalmology & visual science,  54  ((12)): (7189-7197).  [PMID:24130176]
37. Junqi Liu, Meng Wang, Saijin Wang, Yanli Zhao, Shi Zhou, Jinlian Li, Dongmei Wu.  (2024)  Assessment of oxygenated polycyclic aromatic hydrocarbon cytotoxicity using TiO2-MXene/MWCNTs/PDA/GCE electrochemical sensor.  ELECTROCHIMICA ACTA,  474  (8): (143515).  [PMID:9873016] [10.1016/j.electacta.2023.143515]
38. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang.  (2023)  “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process.  ACS Nano,  17  (18): (18227–18239).  [PMID:37668306] [10.1021/acsnano.3c05229]
39. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang.  (2023)  Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl.  ANALYTICAL CHEMISTRY,  95  (8): (4015–4023).  [PMID:36802553] [10.1021/acs.analchem.2c04373]

Solution Calculators