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B101357-5g

Available within 4-8 weeks(?)

$9.90

B101357-25g

25g

In stock

$21.90

B101357-100g

100g

In stock

$57.90

B101357-500g

500g

Available within 4-8 weeks(?)

$181.90

Basic Description

Synonyms	1,3-BENZODIOXOLE \| 274-09-9 \| 1,2-Methylenedioxybenzene \| Benzo[d][1,3]dioxole \| Benzodioxole \| 1,3-Dioxaindan \| 1,2-(Methylenedioxy)benzene \| 2H-1,3-Benzodioxole \| 3,4-Methylenedioxybenzene \| 1,3-Dioxindan \| Methylenedioxybenzene \| o-(Methylenedioxy)benzene \| 1,3-Benzodioxolane
Specifications & Purity	≥99%
Storage Temp	Argon charged
Shipped In	Normal
Note	卖完停产，不再备货
Product Description	Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied.The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported.The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated

Associated Targets(Human)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 (0 Activities)

Discover Target: ABCG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ARG1 Tchem Arginase-1 (0 Activities)

Discover Target: ARG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)

Discover Target: ABCG2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ARG1 Arginase-1 (70 Activities)

Discover Target: ARG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488180948
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488180948
IUPAC Name	1,3-benzodioxole
INCHI	InChI=1S/C7H6O2/c1-2-4-7-6(3-1)8-5-9-7/h1-4H,5H2
InChi Key	FTNJQNQLEGKTGD-UHFFFAOYSA-N
Canonical SMILES	C1OC2=CC=CC=C2O1
Isomeric SMILES	C1OC2=CC=CC=C2O1
WGK Germany	3
RTECS	DA5600000
PubChem CID	9229
UN Number	1993
Molecular Weight	122.12
Beilstein	115506
Reaxy-Rn	115506

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot Number	Certificate Type	Date	Item
H2421261	Certificate of Analysis	Jun 17, 2024	B101357
H2421288	Certificate of Analysis	Jun 17, 2024	B101357
J2227007	Certificate of Analysis	Oct 09, 2022	B101357
J2227008	Certificate of Analysis	Oct 09, 2022	B101357
J2227009	Certificate of Analysis	Oct 09, 2022	B101357
J2227012	Certificate of Analysis	Oct 09, 2022	B101357
C2308327	Certificate of Analysis	Mar 11, 2022	B101357
E2223019	Certificate of Analysis	Mar 11, 2022	B101357
E2223021	Certificate of Analysis	Mar 11, 2022	B101357
E2223022	Certificate of Analysis	Mar 11, 2022	B101357
J2212119	Certificate of Analysis	Oct 19, 2021	B101357

Chemical and Physical Properties

Solubility	Soluble in water (2g/L).Soluble in methanol, ethanol
Sensitivity	Air sensitive
Refractive Index	1.539
Flash Point(°F)	60°C(lit.)
Flash Point(°C)	60°C(lit.)
Boil Point(°C)	172-173°C
Melt Point(°C)	-10 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07, GHS02
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H226:Flammable liquid and vapor H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use ... to extinguish. P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P501:Dispose of contents/container to ... P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P264:Wash hands [and …] thoroughly after handling. P403+P235:Store in a well-ventilated place. Keep cool. P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P271:Use only outdoors or in a well-ventilated area. P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P330:Rinse mouth. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3
RTECS	DA5600000
Reaxy-Rn	115506

References

1. Y Kumagai,L Y Lin,R M Philpot,H Yamada,K Oguri,H Yoshimura,A K Cho. (1992-10-01) Regiochemical differences in cytochrome P450 isozymes responsible for the oxidation of methylenedioxyphenyl groups by rabbit liver.. Molecular pharmacology, 42 ((4)): (695-702). [PMID:1435745]
2. Y Kumagai,L Y Lin,D A Schmitz,A K Cho. (1991-05-01) Hydroxyl radical mediated demethylenation of (methylenedioxy)phenyl compounds.. Chemical research in toxicology, 4 ((3)): (330-334). [PMID:1680477]
3. M Murray,C F Wilkinson,C E Dube. (1985-05-01) Induction of rat-hepatic microsomal cytochrome P-450 and aryl hydrocarbon hydroxylase by 1,3-benzodioxole derivatives.. Xenobiotica; the fate of foreign compounds in biological systems, 15 ((5)): (361-368). [PMID:4036164]
4. A S Tasker,B K Sorensen,H S Jae,M Winn,T W von Geldern,D B Dixon,W J Chiou,B D Dayton,S Calzadila,L Hernandez,K C Marsh,J R WuWong,T J Opgenorth. (1997-01-31) Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.. Journal of medicinal chemistry, 40 ((3)): (322-330). [PMID:9022798]
5. Nicola Micale,Maria Zappalà,Silvana Grasso. (2002-11-08) Synthesis and antitumor activity of 1,3-benzodioxole derivatives.. Farmaco (Societa chimica italiana : 1989), 57 ((10)): (853-859). [PMID:12420881]
6. Angeles Castro,José M Miguel del Corral,Marina Gordaliza,Concepción Grande,Antonia Gómez-Zurita,Dolores García-Grávalos,Arturo San Feliciano. (2003-02-21) Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring.. European journal of medicinal chemistry, 38 ((1)): (65-74). [PMID:12593917]
7. Nicola Micale,Maria Zappalà,Silvana Grasso. (2003-05-06) Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.. Farmaco (Societa chimica italiana : 1989), 58 ((5)): (351-355). [PMID:12729828]
8. Roland F Staack,Hans H Maurer. (2004-03-25) New designer drug 1-(3,4-methylenedioxybenzyl) piperazine (MDBP): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry.. Journal of mass spectrometry : JMS, 39 ((3)): (255-261). [PMID:15039932]
9. Diogo Rodrigo de Magalhães Moreira,Ana Cristina Lima Leite,Paulo Michel Pinheiro Ferreira,Patrícia Marçal da Costa,Letícia Veras Costa Lotufo,Manoel Odorico de Moraes,Dalci José Brondani,Claudia do O Pessoa. (2006-12-19) Synthesis and antitumour evaluation of peptidyl-like derivatives containing the 1,3-benzodioxole system.. European journal of medicinal chemistry, 42 ((3)): (351-357). [PMID:17175071]
10. Marzena Poraj-Kobielska,Matthias Kinne,René Ullrich,Katrin Scheibner,Martin Hofrichter. (2011-11-01) A spectrophotometric assay for the detection of fungal peroxygenases.. Analytical biochemistry, 421 ((1)): (327-329). [PMID:22037293]
11. Emma L McInturff,Eiji Yamaguchi,Michael J Krische. (2012-12-14) Chiral-anion-dependent inversion of diastereo- and enantioselectivity in carbonyl crotylation via ruthenium-catalyzed butadiene hydrohydroxyalkylation.. Journal of the American Chemical Society, 134 ((51)): (20628-20631). [PMID:23234459]
12. Marie-Josée Haglund Halsør,Bjørn Altermark,Inger Lin Uttakleiv Ræder. (2020-07-21) Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa.. Scientific reports, 10 ((1)): (11995-11995). [PMID:32686701]
13. Y Kumagai,D A Schmitz,A K Cho. (1992-04-01) Aromatic hydroxylation of methylenedioxybenzene (MDB) and methylenedioxymethamphetamine (MDMA) by rabbit liver microsomes.. Xenobiotica; the fate of foreign compounds in biological systems, 22 ((4)): (395-403). [PMID:1523860]
14. M W Anders,J M Sunram,C F Wilkinson. (1984-02-15) Mechanism of the metabolism of 1,3-benzodioxoles to carbon monoxide.. Biochemical pharmacology, 33 ((4)): (577-580). [PMID:6704173]
15. J P Wynn,A Kendrick,C Ratledge. (1997-06-01) Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme.. Lipids, 32 ((6)): (605-610). [PMID:9208389]
16. J S Sidhu,C B Marcus,A Parkinson,C J Omiecinski. (1998-07-17) Differential induction of cytochrome P450 gene expression by 4n-alkyl-methylenedioxybenzenes in primary rat hepatocyte cultures.. Journal of biochemical and molecular toxicology, 12 ((5)): (253-262). [PMID:9664231]
17. Suqing Shi,Jun Nie. (2007-01-25) A natural component as coinitiator for unfilled dental resin composites.. Journal of biomedical materials research. Part B, Applied biomaterials, 82 ((1)): (44-50). [PMID:17245738]
18. Davide Ravelli,Angelo Albini,Maurizio Fagnoni. (2011-01-06) Smooth photocatalytic preparation of 2-substituted 1,3-benzodioxoles.. Chemistry (Weinheim an der Bergstrasse, Germany), 17 ((2)): (572-579). [PMID:21207575]
19. Robert Wawrzinek,Pablo Wessig,Kristian Möllnitz,Jörg Nikolaus,Roland Schwarzer,Peter Müller,Andreas Herrmann. (2012-08-04) DBD dyes as fluorescent probes for sensing lipophilic environments.. Bioorganic & medicinal chemistry letters, 22 ((17)): (5367-5371). [PMID:22858138]
20. Ron Amon,Shani Leviatan Ben-Arye,Limor Engler,Hai Yu,Noha Lim,Ludmilla Le Berre,Kristina M Harris,Mario R Ehlers,Stephen E Gitelman,Xi Chen,Jean-Paul Soulillou,Vered Padler-Karavani. (2018-01-20) Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy.. Oncotarget, 8 ((68)): (112236-112244). [PMID:29348821]
21. Md Ariful Hasan,Shabbir Ahmed,Yonggyun Kim. (2019-07-01) Biosynthetic pathway of arachidonic acid in Spodoptera exigua in response to bacterial challenge.. Insect biochemistry and molecular biology, 111 (103179-103179). [PMID:31255640]
22. Ruben Bartholomäus,Simon Nicolussi,Alice Baumann,Mark Rau,Ana Catarina Simão,Jürg Gertsch,Karl-Heinz Altmann. (2019-07-20) Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies.. ChemMedChem, 14 ((17)): (1590-1596). [PMID:31322825]

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1,3-Benzodioxole - 99%, high purity , CAS No.274-09-9