Grouped product items

SKU

Size

Availability

Price

Qty

D154658-25g

25g

In stock

$26.90

D154658-100g

100g

In stock

$95.90

D154658-500g

500g

Available within 4-8 weeks(?)

$137.90

Basic Description

Synonyms	Diorthotolylguanidine \| 1,3-Bis(o-tolyl)guanidine \| GTPL6685 \| N,N'-Di-o-tolueylguanidine \| Tox21_200712 \| 1,2-di-(2-tolyl)guanidine \| D0953 \| Nocceler DT \| Soxinol DT \| 1,3-Di-2-tolylguanidine \| N,N'-BIS(2-METHYLPHENYL)GUANIDINE [HSDB] \| NCI60_004115 \| D
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Displays high and roughly equal affinity for bothσ1andσ2receptors.
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of σ2;Agonist of sigma non-opioid intracellular receptor 1

Associated Targets(Human)

TMEM97 Tchem Sigma intracellular receptor 2 (2 Activities)

Discover Target: TMEM97

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (34 Activities)

Discover Target: SIGMAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD2 Tclin Dopamine D2 receptor (23596 Activities)

Discover Target: DRD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRD1 Tclin Delta opioid receptor (15096 Activities)

Discover Target: OPRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRK1 Tclin Kappa opioid receptor (16155 Activities)

Discover Target: OPRK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIN2B Tclin Glutamate [NMDA] receptor subunit epsilon 2 (467 Activities)

Discover Target: GRIN2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EBP Tchem 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase (102 Activities)

Discover Target: EBP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

Discover Target: ALOX15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

Discover Target: PIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PANC-1 (6144 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SH-SY5Y (11521 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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Associated Targets(non-human)

ERG2 C-8 sterol isomerase (237 Activities)

Discover Target: ERG2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vesicular acetylcholine transporter (105 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sigmar1 Sigma opioid receptor (160 Activities)

Discover Target: Sigmar1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cavia porcellus (23802 Activities)

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Mus musculus (284745 Activities)

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RAW264.7 (28094 Activities)

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SIGMAR1 Sigma-1 receptor (3326 Activities)

Discover Target: SIGMAR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rev Protein Rev (94 Activities)

Discover Target: rev

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

gld-1 Female germline-specific tumor suppressor gld-1 (77 Activities)

Discover Target: gld-1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grin1 Glutamate NMDA receptor (6467 Activities)

Discover Target: Grin1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adra2c Adrenergic receptor alpha-2 (3313 Activities)

Discover Target: Adra2c

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Oprd1 Opioid receptor (994 Activities)

Discover Target: Oprd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tmem97 Sigma intracellular receptor 2 (922 Activities)

Discover Target: Tmem97

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1,2-bis(2-methylphenyl)guanidine
INCHI	InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
InChi Key	OPNUROKCUBTKLF-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=CC=C1NC(=NC2=CC=CC=C2C)N
Isomeric SMILES	CC1=CC=CC=C1NC(=NC2=CC=CC=C2C)N
WGK Germany	3
RTECS	MF1400000
Alternate CAS	97-39-2,41130-39-6 (hydrochloride)
PubChem CID	7333
NSC Number	473
MeSH Entry Terms	1,3-di-(2-tolyl)guanidine;1,3-di-o-tolylguanidine;1,3-di-ortho-tolyl-guanidine;1,3-ditolylguanidine;1,3-ditolylguanidine hydrochloride;N,N'-bis(2-methylphenyl)guanidine
Molecular Weight	239.32
Beilstein	12803
Reaxy-Rn	2653884

Database links

PubChem CID	7333
CAS Registry No.	97-39-2
ChEMBL Ligand	CHEMBL282433
Wikipedia	Ditolylguanidine

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
H2409224	Certificate of Analysis	Apr 17, 2024	D154658
H2409228	Certificate of Analysis	Apr 17, 2024	D154658
H2409229	Certificate of Analysis	Apr 17, 2024	D154658
H1929087	Certificate of Analysis	Jun 07, 2023	D154658
G2211030	Certificate of Analysis	Jul 19, 2022	D154658
H2231429	Certificate of Analysis	Jun 21, 2022	D154658
H2231583	Certificate of Analysis	Jun 21, 2022	D154658

Chemical and Physical Properties

Solubility	Solvent:ethanol, Max Conc. mg/mL: 5.98, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 5.98, Max Conc. mM: 25
Sensitivity	light sensitive
Melt Point(°C)	175 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H301:Toxic if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3
RTECS	MF1400000
Reaxy-Rn	2653884

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ye Gao, Teng Zhang, Changyou Yu, Peiyi Li, Ningning Tian, Songgu Wu. (2020) The effect of solvents on solid-liquid phase equilibrium of 1,3-Di-o-tolylguanidine. JOURNAL OF MOLECULAR LIQUIDS, 309 (113147). [PMID:] [10.1016/j.molliq.2020.113147]
2. Wei Guo, Hui He, Hongxiang Zhu, Xudong Hou, Xingjuan Chen, Shile Zhou, Shuangfei Wang, Lingtao Huang, Jiehan Lin. (2019) Preparation and properties of a biomass cellulose-based colorimetric sensor for Ag+ and Cu2+. INDUSTRIAL CROPS AND PRODUCTS, 137 (410). [PMID:] [10.1016/j.indcrop.2019.05.044]

References

1. Ye Gao, Teng Zhang, Changyou Yu, Peiyi Li, Ningning Tian, Songgu Wu. (2020) The effect of solvents on solid-liquid phase equilibrium of 1,3-Di-o-tolylguanidine. JOURNAL OF MOLECULAR LIQUIDS, 309 (113147). [PMID:] [10.1016/j.molliq.2020.113147]
2. Wei Guo, Hui He, Hongxiang Zhu, Xudong Hou, Xingjuan Chen, Shile Zhou, Shuangfei Wang, Lingtao Huang, Jiehan Lin. (2019) Preparation and properties of a biomass cellulose-based colorimetric sensor for Ag+ and Cu2+. INDUSTRIAL CROPS AND PRODUCTS, 137 (410). [PMID:] [10.1016/j.indcrop.2019.05.044]

Solution Calculators

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1,3-Di-o-tolylguanidine - >99.0%, high purity , CAS No.97-39-2, Agonist of σ2;Agonist of sigma non-opioid intracellular receptor 1

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator