1,4-Naphthoquinone - 97%, high purity , CAS No.130-15-4

  • ≥97%
Item Number
N106403
Grouped product items
SKUSizeAvailabilityPrice Qty
N106403-25g
25g
In stock
$27.90
N106403-100g
100g
In stock
$99.90
N106403-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$446.90

Basic Description

SynonymsN0040 | NCGC00357275-01 | 1,4-NAPHTHOQUINONE [MI] | AI3-24292 | EINECS 204-977-6 | HSDB 2037 | NCGC00164067-01 | STL146359 | naphthalene-1,4-dione | MFCD00001676 | AC-34538 | DTXSID5040704 | naphthalene-1 | Z104494806 | p-Naphthoquinone | 1,4-Naphthylquin
Specifications & Purity≥97%
Shipped InNormal
Product Description

1,4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities. It was also used to inhibit the acetyltransferase activity.

Associated Targets(Human)

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TOP1 Tclin DNA topoisomerase I (7553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CASP3 Tchem Caspase-3 (3632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDC25A Tchem Dual specificity phosphatase Cdc25A (619 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AHR Tclin Aryl hydrocarbon receptor (1071 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMOX2 Tchem Heme oxygenase 2 (250 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMOX1 Tchem Heme oxygenase 1 (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 (4127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDC25C Tchem Dual specificity phosphatase Cdc25C (295 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKACA Tchem cAMP-dependent protein kinase alpha-catalytic subunit (3475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MG-63 (795 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Raji (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2780 (11979 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT1 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PHGDH Tchem D-3-phosphoglycerate dehydrogenase (883 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Papain (844 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
protease Human rhinovirus A protease (1343 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Carbonic anhydrase (69 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterobacter cloacae (7976 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus vulgaris (5823 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-22 (3261 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LLTC cell line (101 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Urease (750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Dusp6 Dual specificity protein phosphatase 6 (459 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
botA Botulinum neurotoxin type A (1303 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Dusp1 Dual specificity protein phosphatase 1 (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
mtcA1 Uncharacterized protein Rv1284/MT1322 (182 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ced-3 Cell death protein 3 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CELA2A Pancreatic elastase (395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
groL GroEL/GroES (1042 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488180823
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180823
IUPAC Name naphthalene-1,4-dione
INCHI InChI=1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H
InChi Key FRASJONUBLZVQX-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=O)C=CC(=O)C2=C1
Isomeric SMILES C1=CC=C2C(=O)C=CC(=O)C2=C1
WGK Germany 3
RTECS QL7175000
UN Number 2811
Packing Group I
Molecular Weight 158.15
Beilstein 878524
Reaxy-Rn 878524

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
K2016048Certificate of AnalysisSep 13, 2024 N106403
C23241184Certificate of AnalysisFeb 01, 2023 N106403
C23241185Certificate of AnalysisFeb 01, 2023 N106403
C23241186Certificate of AnalysisFeb 01, 2023 N106403
C23241229Certificate of AnalysisFeb 01, 2023 N106403
C23241237Certificate of AnalysisFeb 01, 2023 N106403
A2305162Certificate of AnalysisDec 16, 2021 N106403
B2225729Certificate of AnalysisDec 16, 2021 N106403
B2225795Certificate of AnalysisDec 16, 2021 N106403
B2225883Certificate of AnalysisDec 16, 2021 N106403
B2225884Certificate of AnalysisDec 16, 2021 N106403
B2308118Certificate of AnalysisDec 16, 2021 N106403
B2308130Certificate of AnalysisJul 31, 2021 N106403

Show more⌵

Chemical and Physical Properties

SolubilitySoluble in alkali hydroxide solvents, sparingly soluble in petroleum ether and water. Freely soluble in carbondioxide, acetic acid, benzene and choloroform.
Sensitivitylight sensitive
Flash Point(°F)285.8 °F
Flash Point(°C)141°C
Melt Point(°C)120-124°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS09,   GHS05
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H301:Toxic if swallowed

H314:Causes severe skin burns and eye damage

H318:Causes serious eye damage

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

H330:Fatal if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P363:Wash contaminated clothing before reuse.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P330:Rinse mouth.

P320:Specific treatment is urgent (see ... on this label).

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes.

P316:Get emergency medical help immediately.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 3
RTECS QL7175000
Reaxy-Rn 878524
Class 6.1

Related Documents

Citations of This Product

1. Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Yi-Heng P. Job Zhang, Zhiguang Zhu.  (2024)  A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode.  BIOSENSORS & BIOELECTRONICS,  246  (28): (115845).  [PMID:38008057] [10.1016/j.bios.2023.115845]
2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang.  (2023)  “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process.  ACS Nano,  17  (18): (18227–18239).  [PMID:37668306] [10.1021/acsnano.3c05229]
3. Nian Wang, Die Zhou, Huaying Liu, Yina Tu, Yanqiong Ma, Yingjie Li.  (2023)  Triplet-Excited Dissolved Organic Matter Efficiently Promoted Atmospheric Sulfate Production: Kinetics and Mechanisms.  Separations,  10  (6): (335).  [PMID:] [10.3390/separations10060335]
4. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang.  (2023)  Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl.  ANALYTICAL CHEMISTRY,  95  (8): (4015–4023).  [PMID:36802553] [10.1021/acs.analchem.2c04373]
5. Zhang Nana, Li Jian, Zhang Panpan, Yang Xiaodi, Sun Chong.  (2019)  Novel nanoarchitecture of arginine-glycine-aspartate conjugated gold nanoparticles: a sensitive and selective platform for detecting arachidonic acid.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  411  (27): (7105-7113).  [PMID:31515585] [10.1007/s00216-019-02092-7]
6. Qingcai Chen, Haoyao Sun, Mamin Wang, Yuqin Wang, Lixin Zhang, Yuemei Han.  (2019)  Environmentally Persistent Free Radical (EPFR) Formation by Visible-Light Illumination of the Organic Matter in Atmospheric Particles.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  53  (17): (10053–10061).  [PMID:31389239] [10.1021/acs.est.9b02327]
7. Chuantao Hou, Qiaolin Lang, Aihua Liu.  (2016)  Tailoring 1,4-naphthoquinone with electron-withdrawing group: toward developing redox polymer and FAD-GDH based hydrogel bioanode for efficient electrocatalytic glucose oxidation.  ELECTROCHIMICA ACTA,  211  (663).  [PMID:] [10.1016/j.electacta.2016.06.078]
8. Hengnong Li, Chongbo Liu, Bing Dai, Xinghua Tang, Z. John Zhang, Zhiqiang Xiong, Xiaoming Liu.  (2015)  Synthesis, conductivity, and electromagnetic wave absorption properties of chiral poly Schiff bases and their silver complexes.  JOURNAL OF APPLIED POLYMER SCIENCE,  132  (36):   [PMID:] [10.1002/app.42498]
9. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun.  (2014)  Effects of several quinones on insulin aggregation.  Scientific Reports,  (1): (1-8).  [PMID:25008537] [10.1038/srep05648]
10. Xiong Ying, He De-liang, Feng Yong, Zhou Zhou, Chang Xin-yuan, Liu Fu-rong.  (2014)  A rapid method for determination of acid value in transformer oil by PPy modified electrode.  Journal of Central South University,  21  (6): (2202-2207).  [PMID:] [10.1007/s11771-014-2171-5]

References

1. Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S.  (2007)  A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases..  Proc Natl Acad Sci USA,  104  (51): (20523-8).  [PMID:18077363] [10.1021/op500134e]
2. David Kokel,Yehua Li,Jun Qin,Ding Xue.  (2006-05-16)  The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans..  Nature chemical biology,  ((6)): (338-345).  [PMID:16699520]
3. Barbara Krajewska,Wiesława Zaborska.  (2007-04-10)  Double mode of inhibition-inducing interactions of 1,4-naphthoquinone with urease: arylation versus oxidation of enzyme thiols..  Bioorganic & medicinal chemistry,  15  ((12)): (4144-4151).  [PMID:17416528]
4. Cláudia Valente,Rui Moreira,Rita C Guedes,Jim Iley,Mohammed Jaffar,Kenneth T Douglas.  (2007-05-29)  The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors..  Bioorganic & medicinal chemistry,  15  ((15)): (5340-5350).  [PMID:17532221]
5. Sanjeev Kumar,William P Malachowski,James B DuHadaway,Judith M LaLonde,Patrick J Carroll,Daniel Jaller,Richard Metz,George C Prendergast,Alexander J Muller.  (2008-03-06)  Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors..  Journal of medicinal chemistry,  51  ((6)): (1706-1718).  [PMID:18318466]
6. Shugeng Cao,Brian T Murphy,Caleb Foster,John S Lazo,David G I Kingston.  (2008-11-26)  Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases..  Bioorganic & medicinal chemistry,  17  ((6)): (2276-2281).  [PMID:19028102]
7. Leonid R Ptitsyn,Kenzo Nomura,Ilya V Sklyar,Anna B Ravcheeva.  (2011-10-01)  The 1,4-naphthoquinone derivative from Pyrola rotundifolia activates AMPK phosphorylation in C2C12 myotubes..  Fitoterapia,  82  ((8)): (1285-1289).  [PMID:21958969]
8. Dianne Lim,Akihiro Ikeda,Kennedy K-T Vu,Kent T Yamaguchi,Tim R Tyner,Alam S Hasson.  (2011-10-26)  Method development for the measurement of quinone levels in urine..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  879  ((30)): (3592-3598).  [PMID:22024390]
9. Eduardo Coelho Cerqueira,Paulo Augusto Netz,Cristiane Diniz,Vanessa Petry do Canto,Cristian Follmer.  (2011-11-11)  Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO..  Bioorganic & medicinal chemistry,  19  ((24)): (7416-7424).  [PMID:22071524]
10. Michael G Berg,Lili Wan,Ihab Younis,Michael D Diem,Michael Soo,Congli Wang,Gideon Dreyfuss.  (2012-01-19)  A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis..  Molecular and cellular biology,  32  ((7)): (1271-1283).  [PMID:22252314]
11. Alireza Nematollahi,Noushin Aminimoghadamfarouj,Christophe Wiart.  (2012-01-24)  Reviews on 1,4-naphthoquinones from Diospyros L..  Journal of Asian natural products research,  14  ((1)): (80-88).  [PMID:22263598]
12. Yu Shang,Chenyong Chen,Yi Li,Jincai Zhao,Tong Zhu.  (2012-02-01)  Hydroxyl radical generation mechanism during the redox cycling process of 1,4-naphthoquinone..  Environmental science & technology,  46  ((5)): (2935-2942).  [PMID:22288565]
13. Thasni K A,Ratheeshkumar T,Rojini G,Sivakumar K C,Rakesh Sathish Nair,Srinivas G,Asoke Banerji,Veena Somasundaram,Priya Srinivas.  (2012-02-01)  Structure activity relationship of plumbagin in BRCA1 related cancer cells..  Molecular carcinogenesis,  52  ((5)): (392-403).  [PMID:22290577]
14. Mozna H Khraiwesh,Clarence M Lee,Yakini Brandy,Emmanuel S Akinboye,Solomon Berhe,Genelle Gittens,Muneer M Abbas,Franklin R Ampy,Mohammad Ashraf,Oladapo Bakare.  (2012-02-03)  Antitrypanosomal activities and cytotoxicity of some novel imido-substituted 1,4-naphthoquinone derivatives..  Archives of pharmacal research,  35  ((1)): (27-33).  [PMID:22297740]
15. Nanci C de Lucas,Rodrigo J Corrêa,Simon J Garden,Guilherme Santos,Reinaldo Rodrigues,Carlos Eduardo M Carvalho,Sabrina B Ferreira,José Carlos Netto-Ferreira,Vitor F Ferreira,Paula Miro,M Luisa Marin,Miguel A Miranda.  (2012-03-24)  Singlet oxygen production by pyrano and furano 1,4-naphthoquinones in non-aqueous medium..  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology,  11  ((7)): (1201-1209).  [PMID:22441459]
16. Hiromi Sato,Ryota Yamada,Midori Yanagihara,Hiroko Okuzawa,Hiroki Iwata,Ayako Kurosawa,Saki Ichinomiya,Rina Suzuki,Hiroyuki Okabe,Tomohiro Yano,Takuya Kumamoto,Noriyuki Suzuki,Tsutomu Ishikawa,Koichi Ueno.  (2012-03-27)  New 2-aryl-1,4-naphthoquinone-1-oxime methyl ether compound induces microtubule depolymerization and subsequent apoptosis..  Journal of pharmacological sciences,  118  ((4)): (467-478).  [PMID:22447301]
17. Vinayak S Khodade,Allimuthu T Dharmaraja,Harinath Chakrapani.  (2012-05-01)  Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones..  Bioorganic & medicinal chemistry letters,  22  ((11)): (3766-3769).  [PMID:22542016]
18. Don Antoine Lanfranchi,Elena Cesar-Rodo,Benoît Bertrand,Hsin-Hung Huang,Latasha Day,Laure Johann,Mourad Elhabiri,Katja Becker,David L Williams,Elisabeth Davioud-Charvet.  (2012-07-11)  Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents..  Organic & biomolecular chemistry,  10  ((31)): (6375-6387).  [PMID:22777178]
19. Paula F Carneiro,Samara B do Nascimento,Antonio V Pinto,Maria do Carmo F R Pinto,Guilherme C Lechuga,Dilvani O Santos,Helvécio M dos Santos Júnior,Jackson A L C Resende,Saulo C Bourguignon,Vitor F Ferreira.  (2012-07-17)  New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms..  Bioorganic & medicinal chemistry,  20  ((16)): (4995-5000).  [PMID:22795899]
20. Marianne Placzek,Markus Dendorfer,Bernhard Przybilla,Klaus-P Gilbertz,Bernadette Eberlein.  (2012-09-18)  Photosensitizing properties of compounds related to benzophenone..  Acta dermato-venereologica,  93  ((1)): (30-32).  [PMID:22983706]
21. Daniela M Santos,Maria M M Santos,Rui Moreira,Susana Solá,Cecília M P Rodrigues.  (2012-10-12)  Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state..  Molecular neurobiology,  47  ((1)): (313-324).  [PMID:23054678]
22. Fernanda Luna da Silva,Eduardo Coelho Cerqueira,Mônica Santos de Freitas,Daniela Leão Gonçalves,Lilian Terezinha Costa,Cristian Follmer.  (2012-10-16)  Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein..  Neurochemistry international,  62  ((1)): (103-112).  [PMID:23064431]
23. Adriano Olímpio da Silva,Rosangela da Silva Lopes,Ricardo Vieira de Lima,Camila Santos Suniga Tozatti,Maria Rita Marques,Sérgio de Albuquerque,Adilson Beatriz,Dênis Pires de Lima.  (2013-01-03)  Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones..  European journal of medicinal chemistry,  60  (51-56).  [PMID:23279867]
24. Tereza Hartmanová,Vojtěch Tambor,Juraj Lenčo,Claudia A Staab-Weijnitz,Edmund Maser,Vladimír Wsól.  (2013-01-09)  S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity..  Chemico-biological interactions,  202  ((1-3)): (136-145).  [PMID:23295225]
25. Yu Shang,Lanlan Fan,Jialiang Feng,Senlin Lv,Minghong Wu,Bing Li,Yuan-Sheng Zang.  (2013-01-22)  Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: the role of quinones..  Toxicology in vitro : an international journal published in association with BIBRA,  27  ((2)): (922-931).  [PMID:23333790]
26. Yoshiyuki Mizushina,Shin Nishiumi,Masayuki Nishida,Hiromi Yoshida,Takeshi Azuma,Masaru Yoshida.  (2013-01-23)  Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity (Review)..  International journal of oncology,  42  ((3)): (793-802).  [PMID:23338798]
27. Yakini Brandy,Nailah Brandy,Emmanuel Akinboye,Malik Lewis,Claudia Mouamba,Seshat Mack,Ray J Butcher,Alan J Anderson,Oladapo Bakare.  (2013-02-06)  Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives..  Molecules (Basel, Switzerland),  18  ((2)): (1973-1984).  [PMID:23381023]
28. A V Lebedev,M V Ivanova,A A Timoshin,E K Ruuge.  (2013-05-09)  [Paramagnetic calcium melanins]..  Biofizika,  58  ((1)): (47-53).  [PMID:23650854]
29. S Pushpam,M Kottaisamy,V Ramakrishnan.  (2013-06-19)  Dynamic quenching study of 2-amino-3-bromo-1,4-naphthoquinone by titanium dioxide nano particles in solution (methanol)..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  114  (272-276).  [PMID:23774738]
30. Eduardo Coelho-Cerqueira,Paulo A Netz,Vanessa P do Canto,Angelo C Pinto,Cristian Follmer.  (2013-10-30)  Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase..  Chemical biology & drug design,  83  ((4)): (401-410).  [PMID:24165164]
31. Mohankrishna Dalvoy Vasudevarao,Pushpak Mizar,Sujata Kumari,Somnath Mandal,Soumik Siddhanta,Mahadeva M M Swamy,Stephanie Kaypee,Ravindra C Kodihalli,Amrita Banerjee,Chandrabhas Naryana,Dipak Dasgupta,Tapas K Kundu.  (2014-01-29)  Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis..  The Journal of biological chemistry,  289  ((11)): (7702-7717).  [PMID:24469461]
32. Ivana Milackova,Marta Soltesova Prnova,Magdalena Majekova,Ruzena Sotnikova,Michal Stasko,Lucia Kovacikova,Sreeparna Banerjee,Miroslav Veverka,Milan Stefek.  (2014-03-29)  2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent..  Journal of enzyme inhibition and medicinal chemistry,  30  ((1)): (107-113).  [PMID:24666303]
33. Tomohiro Motono,Takashi Nagai,Shinya Kitagawa,Hajime Ohtani.  (2015-04-29)  Chromatographic behavior of small organic compounds in low-temperature high-performance liquid chromatography using liquid carbon dioxide as the mobile phase..  Journal of separation science,  38  ((14)): (2381-2386).  [PMID:25917311]
34. Olivia Berthoumieu,Phuong H Nguyen,Maria P Del Castillo-Frias,Sabrina Ferre,Bogdan Tarus,Jessica Nasica-Labouze,Sabrina Noël,Olivier Saurel,Claire Rampon,Andrew J Doig,Philippe Derreumaux,Peter Faller.  (2015-07-17)  Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp..  Chemistry (Weinheim an der Bergstrasse, Germany),  21  ((36)): (12657-12666).  [PMID:26179053]
35. Justyna McIntyre,Mary P McLenigan,Ekaterina G Frank,Xiaoxia Dai,Wei Yang,Yinsheng Wang,Roger Woodgate.  (2015-09-16)  Posttranslational Regulation of Human DNA Polymerase ι..  The Journal of biological chemistry,  290  ((45)): (27332-27344).  [PMID:26370087]
36. Tianran Sun,Barnaby D A Levin,Juan J L Guzman,Akio Enders,David A Muller,Largus T Angenent,Johannes Lehmann.  (2017-04-01)  Rapid electron transfer by the carbon matrix in natural pyrogenic carbon..  Nature communications,  (14873-14873).  [PMID:28361882]
37. Qianshan Xiong,Haoran Yu,Runran Wang,Jinlai Wei,Vishal Verma.  (2017-05-11)  Rethinking Dithiothreitol-Based Particulate Matter Oxidative Potential: Measuring Dithiothreitol Consumption versus Reactive Oxygen Species Generation..  Environmental science & technology,  51  ((11)): (6507-6514).  [PMID:28489384]
38. Bor-Kai Hsiung,Nicholas M Justyn,Todd A Blackledge,Matthew D Shawkey.  (2017-06-02)  Spiders have rich pigmentary and structural colour palettes..  The Journal of experimental biology,  220  ((Pt 11)): (1975-1983).  [PMID:28566355]
39. Serena Bertoni,Beatrice Albertini,Carlotta Facchini,Cecilia Prata,Nadia Passerini.  (2019-07-31)  Glutathione-Loaded Solid Lipid Microparticles as Innovative Delivery System for Oral Antioxidant Therapy..  Pharmaceutics,  11  ((8)):   [PMID:31357663]
40. Jan Bitenc,Tjaša Pavčnik,Urban Košir,Klemen Pirnat.  (2020-01-25)  Quinone Based Materials as Renewable High Energy Density Cathode Materials for Rechargeable Magnesium Batteries..  Materials (Basel, Switzerland),  13  ((3)):   [PMID:31973193]
41. Anita Mahapatra,Sannah P N Mativandlela,B Binneman,P B Fourie,Chris J Hamilton,J J M Meyer,F van der Kooy,Peter Houghton,Namrita Lall.  (2007-09-25)  Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase..  Bioorganic & medicinal chemistry,  15  ((24)): (7638-7646).  [PMID:17888665]
42. Shalini John,Sundarapandian Thangapandian,Sugunadevi Sakkiah,Keun Woo Lee.  (2010-06-29)  Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies..  European journal of medicinal chemistry,  45  ((9)): (4004-4012).  [PMID:20580138]
43. Rita Gatti,Paolo Andreatta,Silvia Boschetti.  (2012-07-24)  Study of 1,4-naphthoquinone as a new useful derivatization reagent for LC analysis of aliphatic thiols in dietary supplements and pharmaceuticals..  Analytical and bioanalytical chemistry,  405  ((2-3)): (817-825).  [PMID:22820949]
44. Reiko Hirose,Takashi Miura,Ryo Sha,Yasuhiro Shinkai,Toshiko Tanaka-Kagawa,Yoshito Kumagai.  (2012-10-06)  A method for detecting covalent modification of sensor proteins associated with 1,4-naphthoquinone-induced activation of electrophilic signal transduction pathways..  The Journal of toxicological sciences,  37  ((5)): (891-898).  [PMID:23037999]
45. Katarzyna A Broniowska,Anne R Diers,John A Corbett,Neil Hogg.  (2013-05-31)  Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation..  Biochemistry,  52  ((25)): (4364-4372).  [PMID:23718265]
46. Julie A Vrana,Holly N Currie,Alice A Han,Jonathan Boyd.  (2014-05-16)  Forecasting cell death dose-response from early signal transduction responses in vitro..  Toxicological sciences : an official journal of the Society of Toxicology,  140  ((2)): (338-351).  [PMID:24824809]
47. Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Yi-Heng P. Job Zhang, Zhiguang Zhu.  (2024)  A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode.  BIOSENSORS & BIOELECTRONICS,  246  (28): (115845).  [PMID:38008057] [10.1016/j.bios.2023.115845]
48. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang.  (2023)  “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process.  ACS Nano,  17  (18): (18227–18239).  [PMID:37668306] [10.1021/acsnano.3c05229]
49. Nian Wang, Die Zhou, Huaying Liu, Yina Tu, Yanqiong Ma, Yingjie Li.  (2023)  Triplet-Excited Dissolved Organic Matter Efficiently Promoted Atmospheric Sulfate Production: Kinetics and Mechanisms.  Separations,  10  (6): (335).  [PMID:] [10.3390/separations10060335]
50. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang.  (2023)  Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl.  ANALYTICAL CHEMISTRY,  95  (8): (4015–4023).  [PMID:36802553] [10.1021/acs.analchem.2c04373]
51. Zhang Nana, Li Jian, Zhang Panpan, Yang Xiaodi, Sun Chong.  (2019)  Novel nanoarchitecture of arginine-glycine-aspartate conjugated gold nanoparticles: a sensitive and selective platform for detecting arachidonic acid.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  411  (27): (7105-7113).  [PMID:31515585] [10.1007/s00216-019-02092-7]
52. Qingcai Chen, Haoyao Sun, Mamin Wang, Yuqin Wang, Lixin Zhang, Yuemei Han.  (2019)  Environmentally Persistent Free Radical (EPFR) Formation by Visible-Light Illumination of the Organic Matter in Atmospheric Particles.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  53  (17): (10053–10061).  [PMID:31389239] [10.1021/acs.est.9b02327]
53. Chuantao Hou, Qiaolin Lang, Aihua Liu.  (2016)  Tailoring 1,4-naphthoquinone with electron-withdrawing group: toward developing redox polymer and FAD-GDH based hydrogel bioanode for efficient electrocatalytic glucose oxidation.  ELECTROCHIMICA ACTA,  211  (663).  [PMID:] [10.1016/j.electacta.2016.06.078]
54. Hengnong Li, Chongbo Liu, Bing Dai, Xinghua Tang, Z. John Zhang, Zhiqiang Xiong, Xiaoming Liu.  (2015)  Synthesis, conductivity, and electromagnetic wave absorption properties of chiral poly Schiff bases and their silver complexes.  JOURNAL OF APPLIED POLYMER SCIENCE,  132  (36):   [PMID:] [10.1002/app.42498]
55. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun.  (2014)  Effects of several quinones on insulin aggregation.  Scientific Reports,  (1): (1-8).  [PMID:25008537] [10.1038/srep05648]
56. Xiong Ying, He De-liang, Feng Yong, Zhou Zhou, Chang Xin-yuan, Liu Fu-rong.  (2014)  A rapid method for determination of acid value in transformer oil by PPy modified electrode.  Journal of Central South University,  21  (6): (2202-2207).  [PMID:] [10.1007/s11771-014-2171-5]

Solution Calculators