Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | 1,4-NAPHTHOQUINONE | 130-15-4 | naphthalene-1,4-dione | 1,4-Naphthalenedione | p-Naphthoquinone | NAPHTHOQUINONE | alpha-Naphthoquinone | a-naphthoquinone | 1,4-Naphthylquinone | 1,4-Dihydro-1,4-diketonaphthalene | 1,4-Naphthaquinone | USAF CY-10 | 1,4-Naftochinon | RCRA waste num |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | 1,4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities. It was also used to inhibit the acetyltransferase activity. |
Associated Targets(Human)
IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (3 Activities)
TOP1 Tclin DNA topoisomerase I (7553 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
VDR Tclin Vitamin D receptor (26531 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOA Tclin Monoamine oxidase A (11911 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOB Tclin Monoamine oxidase B (8835 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CASP3 Tchem Caspase-3 (3632 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CDC25A Tchem Dual specificity phosphatase Cdc25A (619 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AHR Tclin Aryl hydrocarbon receptor (1071 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HMOX2 Tchem Heme oxygenase 2 (250 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HMOX1 Tchem Heme oxygenase 1 (32 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 (4127 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CDC25C Tchem Dual specificity phosphatase Cdc25C (295 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PRKACA Tchem cAMP-dependent protein kinase alpha-catalytic subunit (3475 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
DU-145 (51482 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HT-29 (80576 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MCF7 (126967 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MG-63 (795 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Raji (5516 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SK-MEL-28 (48833 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SK-OV-3 (52876 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
A549 (127892 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HCT-116 (91556 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HepG2 (196354 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
A2780 (11979 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MDA-MB-231 (73002 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
EHMT1 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (407 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SNCA Tchem Alpha-synuclein (10960 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PHGDH Tchem D-3-phosphoglycerate dehydrogenase (883 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Papain (844 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
protease Human rhinovirus A protease (1343 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Carbonic anhydrase (69 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Pseudomonas aeruginosa (123386 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Enterobacter cloacae (7976 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Klebsiella pneumoniae (43867 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Proteus vulgaris (5823 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Staphylococcus aureus (210822 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Escherichia coli (133304 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mycobacterium tuberculosis (203094 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Enterococcus faecalis (29875 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mus musculus (284745 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Rattus norvegicus (775804 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
P388 (20296 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Vero (26788 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HT-22 (3261 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
LLTC cell line (101 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Urease (750 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Dusp6 Dual specificity protein phosphatase 6 (459 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
botA Botulinum neurotoxin type A (1303 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Dusp1 Dual specificity protein phosphatase 1 (15 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
mtcA1 Uncharacterized protein Rv1284/MT1322 (182 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ced-3 Cell death protein 3 (4 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CELA2A Pancreatic elastase (395 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
groL GroEL/GroES (1042 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | naphthalene-1,4-dione |
|---|---|
| INCHI | InChI=1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H |
| InChi Key | FRASJONUBLZVQX-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C2C(=O)C=CC(=O)C2=C1 |
| Isomeric SMILES | C1=CC=C2C(=O)C=CC(=O)C2=C1 |
| WGK Germany | 3 |
| RTECS | QL7175000 |
| UN Number | 2811 |
| Packing Group | I |
| Molecular Weight | 158.15 |
| Beilstein | 878524 |
| Reaxy-Rn | 878524 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Sensitivity | light sensitive |
|---|---|
| Flash Point(°F) | 285.8 °F |
| Flash Point(°C) | 141°C |
| Melt Point(°C) | 120-124°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS06, GHS09, GHS05 |
|---|---|
| Signal | Danger |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H314:Causes severe skin burns and eye damage H318:Causes serious eye damage H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H330:Fatal if inhaled |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately. |
| WGK Germany | 3 |
| RTECS | QL7175000 |
| Reaxy-Rn | 878524 |
| Class | 6.1 |
Related Documents
Citations of This Product
| 1. Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Yi-Heng P. Job Zhang, Zhiguang Zhu. (2024) A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode. BIOSENSORS & BIOELECTRONICS, 246 (28): (115845). [PMID:38008057] [10.1016/j.bios.2023.115845] |
| 2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
| 3. Nian Wang, Die Zhou, Huaying Liu, Yina Tu, Yanqiong Ma, Yingjie Li. (2023) Triplet-Excited Dissolved Organic Matter Efficiently Promoted Atmospheric Sulfate Production: Kinetics and Mechanisms. Separations, 10 (6): (335). [PMID:] [10.3390/separations10060335] |
| 4. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang. (2023) Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl. ANALYTICAL CHEMISTRY, 95 (8): (4015–4023). [PMID:36802553] [10.1021/acs.analchem.2c04373] |
| 5. Zhang Nana, Li Jian, Zhang Panpan, Yang Xiaodi, Sun Chong. (2019) Novel nanoarchitecture of arginine-glycine-aspartate conjugated gold nanoparticles: a sensitive and selective platform for detecting arachidonic acid. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (27): (7105-7113). [PMID:31515585] [10.1007/s00216-019-02092-7] |
| 6. Qingcai Chen, Haoyao Sun, Mamin Wang, Yuqin Wang, Lixin Zhang, Yuemei Han. (2019) Environmentally Persistent Free Radical (EPFR) Formation by Visible-Light Illumination of the Organic Matter in Atmospheric Particles. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53 (17): (10053–10061). [PMID:31389239] [10.1021/acs.est.9b02327] |
| 7. Chuantao Hou, Qiaolin Lang, Aihua Liu. (2016) Tailoring 1,4-naphthoquinone with electron-withdrawing group: toward developing redox polymer and FAD-GDH based hydrogel bioanode for efficient electrocatalytic glucose oxidation. ELECTROCHIMICA ACTA, 211 (663). [PMID:] [10.1016/j.electacta.2016.06.078] |
| 8. Hengnong Li, Chongbo Liu, Bing Dai, Xinghua Tang, Z. John Zhang, Zhiqiang Xiong, Xiaoming Liu. (2015) Synthesis, conductivity, and electromagnetic wave absorption properties of chiral poly Schiff bases and their silver complexes. JOURNAL OF APPLIED POLYMER SCIENCE, 132 (36): [PMID:] [10.1002/app.42498] |
| 9. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
| 10. Xiong Ying, He De-liang, Feng Yong, Zhou Zhou, Chang Xin-yuan, Liu Fu-rong. (2014) A rapid method for determination of acid value in transformer oil by PPy modified electrode. Journal of Central South University, 21 (6): (2202-2207). [PMID:] [10.1007/s11771-014-2171-5] |
References
| 1. Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Yi-Heng P. Job Zhang, Zhiguang Zhu. (2024) A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode. BIOSENSORS & BIOELECTRONICS, 246 (28): (115845). [PMID:38008057] [10.1016/j.bios.2023.115845] |
| 2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
| 3. Nian Wang, Die Zhou, Huaying Liu, Yina Tu, Yanqiong Ma, Yingjie Li. (2023) Triplet-Excited Dissolved Organic Matter Efficiently Promoted Atmospheric Sulfate Production: Kinetics and Mechanisms. Separations, 10 (6): (335). [PMID:] [10.3390/separations10060335] |
| 4. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang. (2023) Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl. ANALYTICAL CHEMISTRY, 95 (8): (4015–4023). [PMID:36802553] [10.1021/acs.analchem.2c04373] |
| 5. Zhang Nana, Li Jian, Zhang Panpan, Yang Xiaodi, Sun Chong. (2019) Novel nanoarchitecture of arginine-glycine-aspartate conjugated gold nanoparticles: a sensitive and selective platform for detecting arachidonic acid. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (27): (7105-7113). [PMID:31515585] [10.1007/s00216-019-02092-7] |
| 6. Qingcai Chen, Haoyao Sun, Mamin Wang, Yuqin Wang, Lixin Zhang, Yuemei Han. (2019) Environmentally Persistent Free Radical (EPFR) Formation by Visible-Light Illumination of the Organic Matter in Atmospheric Particles. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53 (17): (10053–10061). [PMID:31389239] [10.1021/acs.est.9b02327] |
| 7. Chuantao Hou, Qiaolin Lang, Aihua Liu. (2016) Tailoring 1,4-naphthoquinone with electron-withdrawing group: toward developing redox polymer and FAD-GDH based hydrogel bioanode for efficient electrocatalytic glucose oxidation. ELECTROCHIMICA ACTA, 211 (663). [PMID:] [10.1016/j.electacta.2016.06.078] |
| 8. Hengnong Li, Chongbo Liu, Bing Dai, Xinghua Tang, Z. John Zhang, Zhiqiang Xiong, Xiaoming Liu. (2015) Synthesis, conductivity, and electromagnetic wave absorption properties of chiral poly Schiff bases and their silver complexes. JOURNAL OF APPLIED POLYMER SCIENCE, 132 (36): [PMID:] [10.1002/app.42498] |
| 9. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
| 10. Xiong Ying, He De-liang, Feng Yong, Zhou Zhou, Chang Xin-yuan, Liu Fu-rong. (2014) A rapid method for determination of acid value in transformer oil by PPy modified electrode. Journal of Central South University, 21 (6): (2202-2207). [PMID:] [10.1007/s11771-014-2171-5] |