1-(5-Isoquinolinesulfonyl)-3-methylpiperazine , CAS No.84477-73-6

Item Number
I341808
Grouped product items
SKUSizeAvailabilityPrice Qty
I341808-5mg
5mg
Available within 8-12 weeks(?)
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$74.90

a less potent inhibitor of protein kinase C than H-7

Basic Description

Synonyms1-(6-Isoquinolylsulfonyl)-3-methylpiperazine | NCGC00015561-03 | Z1262449272 | Oprea1_059623 | 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2hcl | NSC683547 | NSC-683547 | CAS_140663-38-3 | NCGC00162215-01 | 5-(3-Methylpiperazine-1-sulfonyl)isoquinoline
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine is a less potent inhibitor of protein kinase C than H-7.

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CBX1 Tbio Chromobox protein homolog 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RGS4 Tchem Regulator of G-protein signaling 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline
INCHI InChI=1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3
InChi Key QGSCXAWTTISKLF-UHFFFAOYSA-N
Canonical SMILES CC1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
Isomeric SMILES CC1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
PubChem CID 1352
Molecular Weight 291.37

Certificates

Certificate of Analysis(COA)

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Related Documents

Citations of This Product

1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang.  (2024)  Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies.  JOURNAL OF MOLECULAR STRUCTURE,  1296  (3): (136938).  [PMID:25527291] [10.1016/j.molstruc.2023.136938]
2. Gui Yueyue, Zeng Yujing, Chen Binrui, Yang Yueping, Ma Jiehua, Li Chao.  (2023)  A smart pathogen detector engineered from intracellular hydrogelation of DNA-decorated macrophages.  Nature Communications,  14  (1): (1-14).  [PMID:37217531] [10.1038/s41467-023-38733-w]
3. Yifang He, Yifang Hua, Jinxuan Chen, Junming Wang, Lijun Qian, Jun Sun, Hongfei Li, Xiaoyu Gu, Sheng Zhang.  (2023)  Preparation of a Novel Phosphorus–Nitrogen-Containing Flame Retardant by Supramolecular Reaction and its Application in Epoxy Resin.  ADVANCED ENGINEERING MATERIALS,  25  (12): (2201815).  [PMID:] [10.1002/adem.202201815]
4. Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du, Yun-Kun Qi.  (2022)  Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage.  Frontiers in Oncology,  12  (1028600).  [PMID:36713538] [10.3389/fonc.2022.1028600]
5. Ping Chen, Xiaoyong Zhao, Hui Wang, Mengdan Zheng, Qinghua Wang, Wenjuan Chang.  (2022)  The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway.  OncoTargets and Therapy,      [PMID:31853187] [10.2147/OTT.S225235]
6. Pengxiang Zhao, Yi Jin, Xiang Wu, Jin Huang, Lupeng Chen, Yanjie Tan, Hong Yuan, Jian Wu, Zhuqing Ren.  (2022)  Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity.  Nanomaterials,  12  (4): (672).  [PMID:35215001] [10.3390/nano12040672]
7. Lixia Chen, Yang Zhang, Xinming Zhang, Ruijuan Lv, Rongtian Sheng, Ruimeng Sun, Ting Du, Yuhan Li, Yanfei Qi.  (2022)  A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy.  MOLECULES,  27  (1): (128).  [PMID:35011360] [10.3390/molecules27010128]
8. Guozhang Wu, Yuanbiao Liu, Gaopeng Shi.  (2021)  New Experimental Evidence for Thermodynamic Links to the Kinetic Fragility of Glass-Forming Polymers.  MACROMOLECULES,  54  (12): (5595–5606).  [PMID:] [10.1021/acs.macromol.1c00670]
9. Bin Shang, Yuan Zhan, Min Chen, Limin Wu.  (2020)  NIR triggered healable underwater superoleophobic coating with exceptional anti-biofouling performance.  APPLIED SURFACE SCIENCE,  528  (146805).  [PMID:] [10.1016/j.apsusc.2020.146805]
10. Zhiyong Song, Huajuan Wang, Yang Wu, Jiangjiang Gu, Shuojun Li, Heyou Han.  (2018)  Fabrication of Bis-Quaternary Ammonium Salt as an Efficient Bactericidal Weapon Against Escherichia coli and Staphylococcus aureus.  ACS Omega,  (10): (14517–14525).  [PMID:30411069] [10.1021/acsomega.8b01265]
11. Ben Wang, Kai Fung Chan, Jiangfan Yu, Qianqian Wang, Lidong Yang, Philip Wai Yan Chiu, Li Zhang.  (2018)  Reconfigurable Swarms of Ferromagnetic Colloids for Enhanced Local Hyperthermia.  ADVANCED FUNCTIONAL MATERIALS,  28  (25): (1705701).  [PMID:] [10.1002/adfm.201705701]
12. Zuhong Li, Haibo Wang, Yangjun Chen, Yin Wang, Huan Li, Haijie Han, Tingting Chen, Qiao Jin, Jian Ji.  (2016)  pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment.  Small,  12  (20): (2731-2740).  [PMID:27043935] [10.1002/smll.201600365]

References

1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang.  (2024)  Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies.  JOURNAL OF MOLECULAR STRUCTURE,  1296  (3): (136938).  [PMID:25527291] [10.1016/j.molstruc.2023.136938]
2. Gui Yueyue, Zeng Yujing, Chen Binrui, Yang Yueping, Ma Jiehua, Li Chao.  (2023)  A smart pathogen detector engineered from intracellular hydrogelation of DNA-decorated macrophages.  Nature Communications,  14  (1): (1-14).  [PMID:37217531] [10.1038/s41467-023-38733-w]
3. Yifang He, Yifang Hua, Jinxuan Chen, Junming Wang, Lijun Qian, Jun Sun, Hongfei Li, Xiaoyu Gu, Sheng Zhang.  (2023)  Preparation of a Novel Phosphorus–Nitrogen-Containing Flame Retardant by Supramolecular Reaction and its Application in Epoxy Resin.  ADVANCED ENGINEERING MATERIALS,  25  (12): (2201815).  [PMID:] [10.1002/adem.202201815]
4. Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du, Yun-Kun Qi.  (2022)  Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage.  Frontiers in Oncology,  12  (1028600).  [PMID:36713538] [10.3389/fonc.2022.1028600]
5. Ping Chen, Xiaoyong Zhao, Hui Wang, Mengdan Zheng, Qinghua Wang, Wenjuan Chang.  (2022)  The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway.  OncoTargets and Therapy,      [PMID:31853187] [10.2147/OTT.S225235]
6. Pengxiang Zhao, Yi Jin, Xiang Wu, Jin Huang, Lupeng Chen, Yanjie Tan, Hong Yuan, Jian Wu, Zhuqing Ren.  (2022)  Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity.  Nanomaterials,  12  (4): (672).  [PMID:35215001] [10.3390/nano12040672]
7. Lixia Chen, Yang Zhang, Xinming Zhang, Ruijuan Lv, Rongtian Sheng, Ruimeng Sun, Ting Du, Yuhan Li, Yanfei Qi.  (2022)  A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy.  MOLECULES,  27  (1): (128).  [PMID:35011360] [10.3390/molecules27010128]
8. Guozhang Wu, Yuanbiao Liu, Gaopeng Shi.  (2021)  New Experimental Evidence for Thermodynamic Links to the Kinetic Fragility of Glass-Forming Polymers.  MACROMOLECULES,  54  (12): (5595–5606).  [PMID:] [10.1021/acs.macromol.1c00670]
9. Bin Shang, Yuan Zhan, Min Chen, Limin Wu.  (2020)  NIR triggered healable underwater superoleophobic coating with exceptional anti-biofouling performance.  APPLIED SURFACE SCIENCE,  528  (146805).  [PMID:] [10.1016/j.apsusc.2020.146805]
10. Zhiyong Song, Huajuan Wang, Yang Wu, Jiangjiang Gu, Shuojun Li, Heyou Han.  (2018)  Fabrication of Bis-Quaternary Ammonium Salt as an Efficient Bactericidal Weapon Against Escherichia coli and Staphylococcus aureus.  ACS Omega,  (10): (14517–14525).  [PMID:30411069] [10.1021/acsomega.8b01265]
11. Ben Wang, Kai Fung Chan, Jiangfan Yu, Qianqian Wang, Lidong Yang, Philip Wai Yan Chiu, Li Zhang.  (2018)  Reconfigurable Swarms of Ferromagnetic Colloids for Enhanced Local Hyperthermia.  ADVANCED FUNCTIONAL MATERIALS,  28  (25): (1705701).  [PMID:] [10.1002/adfm.201705701]
12. Zuhong Li, Haibo Wang, Yangjun Chen, Yin Wang, Huan Li, Haijie Han, Tingting Chen, Qiao Jin, Jian Ji.  (2016)  pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment.  Small,  12  (20): (2731-2740).  [PMID:27043935] [10.1002/smll.201600365]

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