Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
I341808-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $74.90 |
a less potent inhibitor of protein kinase C than H-7
Synonyms | 1-(6-Isoquinolylsulfonyl)-3-methylpiperazine | NCGC00015561-03 | Z1262449272 | Oprea1_059623 | 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2hcl | NSC683547 | NSC-683547 | CAS_140663-38-3 | NCGC00162215-01 | 5-(3-Methylpiperazine-1-sulfonyl)isoquinoline |
---|---|
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Product Description | 1-(5-Isoquinolinesulfonyl)-3-methylpiperazine is a less potent inhibitor of protein kinase C than H-7. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|
IUPAC Name | 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline |
---|---|
INCHI | InChI=1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3 |
InChi Key | QGSCXAWTTISKLF-UHFFFAOYSA-N |
Canonical SMILES | CC1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3 |
Isomeric SMILES | CC1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3 |
PubChem CID | 1352 |
Molecular Weight | 291.37 |
Enter Lot Number to search for COA:
1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang. (2024) Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies. JOURNAL OF MOLECULAR STRUCTURE, 1296 (3): (136938). [PMID:25527291] [10.1016/j.molstruc.2023.136938] |
2. Gui Yueyue, Zeng Yujing, Chen Binrui, Yang Yueping, Ma Jiehua, Li Chao. (2023) A smart pathogen detector engineered from intracellular hydrogelation of DNA-decorated macrophages. Nature Communications, 14 (1): (1-14). [PMID:37217531] [10.1038/s41467-023-38733-w] |
3. Yifang He, Yifang Hua, Jinxuan Chen, Junming Wang, Lijun Qian, Jun Sun, Hongfei Li, Xiaoyu Gu, Sheng Zhang. (2023) Preparation of a Novel Phosphorus–Nitrogen-Containing Flame Retardant by Supramolecular Reaction and its Application in Epoxy Resin. ADVANCED ENGINEERING MATERIALS, 25 (12): (2201815). [PMID:] [10.1002/adem.202201815] |
4. Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du, Yun-Kun Qi. (2022) Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage. Frontiers in Oncology, 12 (1028600). [PMID:36713538] [10.3389/fonc.2022.1028600] |
5. Ping Chen, Xiaoyong Zhao, Hui Wang, Mengdan Zheng, Qinghua Wang, Wenjuan Chang. (2022) The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway. OncoTargets and Therapy, [PMID:31853187] [10.2147/OTT.S225235] |
6. Pengxiang Zhao, Yi Jin, Xiang Wu, Jin Huang, Lupeng Chen, Yanjie Tan, Hong Yuan, Jian Wu, Zhuqing Ren. (2022) Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity. Nanomaterials, 12 (4): (672). [PMID:35215001] [10.3390/nano12040672] |
7. Lixia Chen, Yang Zhang, Xinming Zhang, Ruijuan Lv, Rongtian Sheng, Ruimeng Sun, Ting Du, Yuhan Li, Yanfei Qi. (2022) A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy. MOLECULES, 27 (1): (128). [PMID:35011360] [10.3390/molecules27010128] |
8. Guozhang Wu, Yuanbiao Liu, Gaopeng Shi. (2021) New Experimental Evidence for Thermodynamic Links to the Kinetic Fragility of Glass-Forming Polymers. MACROMOLECULES, 54 (12): (5595–5606). [PMID:] [10.1021/acs.macromol.1c00670] |
9. Bin Shang, Yuan Zhan, Min Chen, Limin Wu. (2020) NIR triggered healable underwater superoleophobic coating with exceptional anti-biofouling performance. APPLIED SURFACE SCIENCE, 528 (146805). [PMID:] [10.1016/j.apsusc.2020.146805] |
10. Zhiyong Song, Huajuan Wang, Yang Wu, Jiangjiang Gu, Shuojun Li, Heyou Han. (2018) Fabrication of Bis-Quaternary Ammonium Salt as an Efficient Bactericidal Weapon Against Escherichia coli and Staphylococcus aureus. ACS Omega, 3 (10): (14517–14525). [PMID:30411069] [10.1021/acsomega.8b01265] |
11. Ben Wang, Kai Fung Chan, Jiangfan Yu, Qianqian Wang, Lidong Yang, Philip Wai Yan Chiu, Li Zhang. (2018) Reconfigurable Swarms of Ferromagnetic Colloids for Enhanced Local Hyperthermia. ADVANCED FUNCTIONAL MATERIALS, 28 (25): (1705701). [PMID:] [10.1002/adfm.201705701] |
12. Zuhong Li, Haibo Wang, Yangjun Chen, Yin Wang, Huan Li, Haijie Han, Tingting Chen, Qiao Jin, Jian Ji. (2016) pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment. Small, 12 (20): (2731-2740). [PMID:27043935] [10.1002/smll.201600365] |
1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang. (2024) Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies. JOURNAL OF MOLECULAR STRUCTURE, 1296 (3): (136938). [PMID:25527291] [10.1016/j.molstruc.2023.136938] |
2. Gui Yueyue, Zeng Yujing, Chen Binrui, Yang Yueping, Ma Jiehua, Li Chao. (2023) A smart pathogen detector engineered from intracellular hydrogelation of DNA-decorated macrophages. Nature Communications, 14 (1): (1-14). [PMID:37217531] [10.1038/s41467-023-38733-w] |
3. Yifang He, Yifang Hua, Jinxuan Chen, Junming Wang, Lijun Qian, Jun Sun, Hongfei Li, Xiaoyu Gu, Sheng Zhang. (2023) Preparation of a Novel Phosphorus–Nitrogen-Containing Flame Retardant by Supramolecular Reaction and its Application in Epoxy Resin. ADVANCED ENGINEERING MATERIALS, 25 (12): (2201815). [PMID:] [10.1002/adem.202201815] |
4. Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du, Yun-Kun Qi. (2022) Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage. Frontiers in Oncology, 12 (1028600). [PMID:36713538] [10.3389/fonc.2022.1028600] |
5. Ping Chen, Xiaoyong Zhao, Hui Wang, Mengdan Zheng, Qinghua Wang, Wenjuan Chang. (2022) The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway. OncoTargets and Therapy, [PMID:31853187] [10.2147/OTT.S225235] |
6. Pengxiang Zhao, Yi Jin, Xiang Wu, Jin Huang, Lupeng Chen, Yanjie Tan, Hong Yuan, Jian Wu, Zhuqing Ren. (2022) Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity. Nanomaterials, 12 (4): (672). [PMID:35215001] [10.3390/nano12040672] |
7. Lixia Chen, Yang Zhang, Xinming Zhang, Ruijuan Lv, Rongtian Sheng, Ruimeng Sun, Ting Du, Yuhan Li, Yanfei Qi. (2022) A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy. MOLECULES, 27 (1): (128). [PMID:35011360] [10.3390/molecules27010128] |
8. Guozhang Wu, Yuanbiao Liu, Gaopeng Shi. (2021) New Experimental Evidence for Thermodynamic Links to the Kinetic Fragility of Glass-Forming Polymers. MACROMOLECULES, 54 (12): (5595–5606). [PMID:] [10.1021/acs.macromol.1c00670] |
9. Bin Shang, Yuan Zhan, Min Chen, Limin Wu. (2020) NIR triggered healable underwater superoleophobic coating with exceptional anti-biofouling performance. APPLIED SURFACE SCIENCE, 528 (146805). [PMID:] [10.1016/j.apsusc.2020.146805] |
10. Zhiyong Song, Huajuan Wang, Yang Wu, Jiangjiang Gu, Shuojun Li, Heyou Han. (2018) Fabrication of Bis-Quaternary Ammonium Salt as an Efficient Bactericidal Weapon Against Escherichia coli and Staphylococcus aureus. ACS Omega, 3 (10): (14517–14525). [PMID:30411069] [10.1021/acsomega.8b01265] |
11. Ben Wang, Kai Fung Chan, Jiangfan Yu, Qianqian Wang, Lidong Yang, Philip Wai Yan Chiu, Li Zhang. (2018) Reconfigurable Swarms of Ferromagnetic Colloids for Enhanced Local Hyperthermia. ADVANCED FUNCTIONAL MATERIALS, 28 (25): (1705701). [PMID:] [10.1002/adfm.201705701] |
12. Zuhong Li, Haibo Wang, Yangjun Chen, Yin Wang, Huan Li, Haijie Han, Tingting Chen, Qiao Jin, Jian Ji. (2016) pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment. Small, 12 (20): (2731-2740). [PMID:27043935] [10.1002/smll.201600365] |