1-(5-Isoquinolinesulfonyl)-3-methylpiperazine , CAS No.84477-73-6

7 Citations
Item Number
I341808
Grouped product items
SKUSizeAvailabilityPrice Qty
I341808-5mg
5mg
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$74.90

a less potent inhibitor of protein kinase C than H-7

Basic Description

Synonyms1-(6-Isoquinolylsulfonyl)-3-methylpiperazine | NCGC00015561-03 | Z1262449272 | Oprea1_059623 | 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2hcl | NSC683547 | NSC-683547 | CAS_140663-38-3 | NCGC00162215-01 | 5-(3-Methylpiperazine-1-sulfonyl)isoquinoline
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine is a less potent inhibitor of protein kinase C than H-7.

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CBX1 Tbio Chromobox protein homolog 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RGS4 Tchem Regulator of G-protein signaling 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 5-(3-methylpiperazin-1-yl)sulfonylisoquinoline
INCHI InChI=1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3
InChi Key QGSCXAWTTISKLF-UHFFFAOYSA-N
Canonical SMILES CC1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
Isomeric SMILES CC1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
PubChem CID 1352
Molecular Weight 291.37

Certificates

Certificate of Analysis(COA)

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Related Documents

Citations of This Product

1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang.  (2024)  Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies.  JOURNAL OF MOLECULAR STRUCTURE,  1296  (3): (136938).  [PMID:25527291]
2. Gui Yueyue, Zeng Yujing, Chen Binrui, Yang Yueping, Ma Jiehua, Li Chao.  (2023)  A smart pathogen detector engineered from intracellular hydrogelation of DNA-decorated macrophages.  Nature Communications,  14  (1): (1-14).  [PMID:37217531]
3. Yifang He, Yifang Hua, Jinxuan Chen, Junming Wang, Lijun Qian, Jun Sun, Hongfei Li, Xiaoyu Gu, Sheng Zhang.  (2023)  Preparation of a Novel Phosphorus–Nitrogen-Containing Flame Retardant by Supramolecular Reaction and its Application in Epoxy Resin.  ADVANCED ENGINEERING MATERIALS,  25  (12): (2201815).  [PMID:]
4. Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du, Yun-Kun Qi.  (2022)  Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage.  Frontiers in Oncology,  12  (1028600).  [PMID:36713538]
5. Ping Chen, Xiaoyong Zhao, Hui Wang, Mengdan Zheng, Qinghua Wang, Wenjuan Chang.  (2022)  The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway.  OncoTargets and Therapy,      [PMID:31853187]
6. Pengxiang Zhao, Yi Jin, Xiang Wu, Jin Huang, Lupeng Chen, Yanjie Tan, Hong Yuan, Jian Wu, Zhuqing Ren.  (2022)  Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity.  Nanomaterials,  12  (4): (672).  [PMID:35215001]
7. Lixia Chen, Yang Zhang, Xinming Zhang, Ruijuan Lv, Rongtian Sheng, Ruimeng Sun, Ting Du, Yuhan Li, Yanfei Qi.  (2022)  A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy.  MOLECULES,  27  (1): (128).  [PMID:35011360]

References

1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang.  (2024)  Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies.  JOURNAL OF MOLECULAR STRUCTURE,  1296  (3): (136938).  [PMID:25527291]
2. Gui Yueyue, Zeng Yujing, Chen Binrui, Yang Yueping, Ma Jiehua, Li Chao.  (2023)  A smart pathogen detector engineered from intracellular hydrogelation of DNA-decorated macrophages.  Nature Communications,  14  (1): (1-14).  [PMID:37217531]
3. Yifang He, Yifang Hua, Jinxuan Chen, Junming Wang, Lijun Qian, Jun Sun, Hongfei Li, Xiaoyu Gu, Sheng Zhang.  (2023)  Preparation of a Novel Phosphorus–Nitrogen-Containing Flame Retardant by Supramolecular Reaction and its Application in Epoxy Resin.  ADVANCED ENGINEERING MATERIALS,  25  (12): (2201815).  [PMID:]
4. Hao Yin, Xingyan Fu, Hanyu Gao, Han Gao, Yannan Ma, Xitong Chen, Xueqi Zhang, Shan-Shan Du, Yun-Kun Qi.  (2022)  Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage.  Frontiers in Oncology,  12  (1028600).  [PMID:36713538]
5. Ping Chen, Xiaoyong Zhao, Hui Wang, Mengdan Zheng, Qinghua Wang, Wenjuan Chang.  (2022)  The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway.  OncoTargets and Therapy,      [PMID:31853187]
6. Pengxiang Zhao, Yi Jin, Xiang Wu, Jin Huang, Lupeng Chen, Yanjie Tan, Hong Yuan, Jian Wu, Zhuqing Ren.  (2022)  Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity.  Nanomaterials,  12  (4): (672).  [PMID:35215001]
7. Lixia Chen, Yang Zhang, Xinming Zhang, Ruijuan Lv, Rongtian Sheng, Ruimeng Sun, Ting Du, Yuhan Li, Yanfei Qi.  (2022)  A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy.  MOLECULES,  27  (1): (128).  [PMID:35011360]

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