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1-[5-tert-butyl-2-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]pyrazol-3-yl]-3-[(1S,4R)-4-[[3-[(2S)-2-methylpiperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]oxy]-1,2,3,4-tetrahydronaphthalen-1-yl]urea , CAS No.1443242-46-3, Inhibitor of mitogen-activated protein kinase 11;Inhibitor of mitogen-activated protein kinase 12;Inhibitor of mitogen-activated protein kinase 13;Inhibitor of mitogen-activated protein kinase 14

Moligand™

CAS#: 1443242-46-3
PubChem CID: 89612265

Item Number

T609257

Grouped product items
SKU	Size	Availability	Price	Qty
T609257-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$680.90
T609257-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,020.90

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mitogen-activated protein kinase 11 Inhibitor mitogen-activated protein kinase 12 Inhibitor mitogen-activated protein kinase 13 Inhibitor mitogen-activated protein kinase 14 Inhibitor

Basic Description

Synonyms	AM9K4SZ3XK\|CHF-6297\|p38-\|A MAPK-IN-5\|UNII-AM9K4SZ3XK\|CHEMBL5202475\|1443242-46-3\|compound 4e [PMID: 35546685]\|Urea, N-(1'-(2-(dimethylamino)ethyl)-3-(1,1-dimethylethyl)(1,4'-bi-1H-pyrazol)-5-yl)-N'-((1S,4R)-1,2,3,4-tetrahydro-4-((3-((2S)-2-methyl-1-piperid
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase 11;Inhibitor of mitogen-activated protein kinase 12;Inhibitor of mitogen-activated protein kinase 13;Inhibitor of mitogen-activated protein kinase 14

Associated Targets

EPHA4 Tchem Ephrin type-A receptor 4 0 Activities

Discover Target: EPHA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DDR2 Tchem Discoidin domain-containing receptor 2 0 Activities

Discover Target: DDR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CIT Tchem Citron Rho-interacting kinase 0 Activities

Discover Target: CIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DDR1 Tchem Epithelial discoidin domain-containing receptor 1 0 Activities

Discover Target: DDR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNIK Tchem TRAF2 and NCK-interacting protein kinase 0 Activities

Discover Target: TNIK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK12 Tchem Mitogen-activated protein kinase 12 0 Activities

Discover Target: MAPK12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK11 Tchem Mitogen-activated protein kinase 11 0 Activities

Discover Target: MAPK11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK13 Tchem Mitogen-activated protein kinase 13 0 Activities

Discover Target: MAPK13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities

Discover Target: MAPK14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-[5-tert-butyl-2-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]pyrazol-3-yl]-3-[(1S,4R)-4-[[3-[(2S)-2-methylpiperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]oxy]-1,2,3,4-tetrahydronaphthalen-1-yl]urea
INCHI	InChI=1S/C37H49N11O2/c1-25-11-9-10-18-46(25)36-42-41-33-17-14-27(24-47(33)36)50-31-16-15-30(28-12-7-8-13-29(28)31)39-35(49)40-34-21-32(37(2,3)4)43-48(34)26-22-38-45(23-26)20-19-44(5)6/h7-8,12-14,17,21-25,30-31H,9-11,15-16,18-20H2,1-6H3,(H2,39,40,49)/t25-,30-,31+/m0/s1
InChi Key	PPZSTJQLZOPKBO-LGXAAPQCSA-N
Canonical SMILES	O=C(Nc1cc(C(C)(C)C)nn1c1cn(CCN(C)C)nc1)N[C@H]1CC[C@@H](Oc2ccc3n(c2)c(nn3)N2[C@@H](C)CCCC2)c2c1cccc2
Isomeric SMILES	C[C@H]1CCCCN1C2=NN=C3N2C=C(C=C3)O[C@@H]4CC[C@@H](C5=CC=CC=C45)NC(=O)NC6=CC(=NN6C7=CN(N=C7)CCN(C)C)C(C)(C)C
PubChem CID	89612265

PubChem CID

89612265

CAS Registry No.

1443242-46-3

References

1. Armani E, Capaldi C, Bagnacani V, Saccani F, Aquino G, Puccini P, Facchinetti F, Martucci C, Moretto N, Villetti G et al.. (2022) Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.. J Med Chem, 65 (10): (7170-7192). [PMID:35546685]

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