Determine the necessary mass, volume, or concentration for preparing a solution.
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Synonyms | amantadine | 1-Adamantanamine | 768-94-5 | adamantan-1-amine | 1-Adamantylamine | 1-Aminoadamantane | Adamantanamine | Adamantylamine | Aminoadamantane | Amantidine | Pk-merz | Adamantamine | Symadine | 1-Adamantamine | Amantadina | Amantadinum | adamantan-1-ylamine | Gocovri | Amantadinum |
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Specifications & Purity | Moligand™, 2mM in DMSO |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Building block for an L-piperidinamide catalyst used in an enantioselective Strecker reaction of phosphinoyl imines. application: 1-Adamantanamine acts as a catalyst in enantioselective strecker reaction of phosphinoyl imines. It is also useful for making adamantane derivatives, i.e. amantadine hydrochloride. It is used in the pharmaceutical industry as antiviral and an antiparkinsonian drug. |
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IUPAC Name | adamantan-1-amine |
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INCHI | InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2 |
InChi Key | DKNWSYNQZKUICI-UHFFFAOYSA-N |
Canonical SMILES | C1C2CC3CC1CC(C2)(C3)N |
Isomeric SMILES | C1C2CC3CC1CC(C2)(C3)N |
WGK Germany | 3 |
RTECS | YD1925000 |
PubChem CID | 2130 |
Molecular Weight | 151.25 |
Beilstein | 2204333 |
Reaxy-Rn | 2204333 |
Enter Lot Number to search for COA:
Sensitivity | air sensitive |
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Melt Point(°C) | 206-208 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H226:Flammable liquid and vapor |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use ... to extinguish. P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P264:Wash hands [and …] thoroughly after handling. P403+P235:Store in a well-ventilated place. Keep cool. P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P271:Use only outdoors or in a well-ventilated area. P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | YD1925000 |
Reaxy-Rn | 2204333 |
Merck Index | 374 |
1. Qiuhui Hu, Bo Zhang, Huiming Ren, Xiaoxuan Zhou, Chengbin He, Youqing Shen, Zhuxian Zhou, Hongjie Hu. (2023) Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications. Acta Biomaterialia, 168 (617). [PMID:37482147] |
2. Pengfei Ren, Liuxin Yang, Dandan Wei, Min Liang, Li Xu, Tianzhu Zhang, Wanjun Hu, Zhigang Zhang, Qianli Zhang. (2023) Alginate/polyacrylamide host-guest supramolecular hydrogels with enhanced adhesion. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 242 (124885). [PMID:37196725] |
3. Lulu Han, Jiaxin Ji, Chong Zhang, Bingjian Sun, Zhenhua Chao, Hua Zhu, Xiaorong Gao, Jun Ren, Fangling Ji, Liming Ma, Lingyun Jia. (2023) One-Step Assembly of Versatile Multifunctional Coatings Based on Host-Guest and Polyphenol Chemistry. Small, 19 (22): (2206943). [PMID:36755211] |
4. Cheng Gao, Cheryl H. T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Simon Ming-Yuen Lee, Guosong Chen, Ruibing Wang. (2023) Conjugation of Macrophage-Mimetic Microalgae and Liposome for Antitumor Sonodynamic Immunotherapy via Hypoxia Alleviation and Autophagy Inhibition. ACS Nano, 17 (4): (4034–4049). [PMID:36739531] |
5. Yuan-Yuan Liu, Jie Liu, Hao Wu, Qiangqiang Zhang, Xue-Rui Tang, Dan Li, Chen-Si Li, Yuanfang Liu, Aoneng Cao, Haifang Wang. (2023) Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells. Nanomaterials, 13 (1): (84). [PMID:36615994] |
6. Tianyue Wu, Kefei Zhao, Chenhui Zhang, Tingjun Zhong, Zilu Li, Zhenping Bao, Yuxia Gao, Fengpei Du. (2022) Promising Delivery Platform for Smart Pest Control with High Water-Retaining Capacity. ACS Applied Materials & Interfaces, 14 (49): (55062–55074). [PMID:36472305] |
7. Tong Sun, Dong Hu, Zhizhang Guo, Hanwen Gong, Qiangwei Xin, Yandong Mu, Jie Weng, Jianshu Li, Xingyu Chen. (2023) Hexapeptide decorated β-cyclodextrin delivery system for targeted therapy of bone infection. JOURNAL OF CONTROLLED RELEASE, 353 (337). [PMID:36462641] |
8. Wenda Zhu, Yiping Fan, Yanbing Li, Lizhi Peng, Yifang Li, Fengxia Yan, Jiaqiang Zhao, Lei Zhang, Hiroshi Kurihara, Rongrong He, Heru Chen. (2023) Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects. BIOORGANIC CHEMISTRY, 130 (106223). [PMID:36356372] |
9. Junqing Shen, Ping Guan, Aiyun Jiang, Wentao Fan, Shengnan Li, Yingliang Liu, Shengang Xu, Shaokui Cao. (2022) A Polyanionic Strategy to Modify the Perovskite Grain Boundary for a Larger Switching Ratio in Flexible Woven Resistive Random-Access Memories. ACS Applied Materials & Interfaces, 14 (39): (44652–44664). [PMID:36125291] |
10. Jiaxin Zhao, Mingjuan Zhou, Yan Zhou, Danming Chao. (2022) Multi-stimuli-responsive color/fluorescence dual-switching behavior of a hyperbranched polyamidoamine bearing viologen and adamantane units. EUROPEAN POLYMER JOURNAL, 176 (111404). [PMID:] |
11. Pengfei Ren, Dandan Wei, Min Liang, Li Xu, Tianzhu Zhang, Qianli Zhang. (2022) Alginate/gelatin-based hybrid hydrogels with function of injecting and encapsulating cells in situ. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 212 (67). [PMID:35588977] |
12. Q. Wang, X. Yu, Y. Zhao, Y. Wang, K. Chen, Y. Liu, B. Wang, H. Zhang, Y. Sun. (2022) Friction-induced supramolecular nanovalves for the potential treatment of osteoarthritis. Materials Today Chemistry, 24 (100876). [PMID:] |
13. Song Zhu, Fei Luo, Bin Zhu, Fei Ling, Er-Long Wang, Tian-Qiang Liu, Gao-Xue Wang. (2021) A Nanobody-Mediated Virus-Targeting Drug Delivery Platform for the Central Nervous System Viral Disease Therapy. Microbiology Spectrum, 9 (3): [PMID:34817277] |
14. Rongqiang Liao,Shouhui Yi,Manshuo Liu,Wenling Jin,Bo Yang. (2015-06-03) Folic-Acid-Targeted Self-Assembling Supramolecular Carrier for Gene Delivery.. Chembiochem : a European journal of chemical biology, 16 ((11)): (1622-1628). [PMID:26032689] |
15. Dongjing Zhang,Cheng Zhou,Pin Lv,Yulin Zhao,Jing Liang,Xiali Liao,Bo Yang. (2018-03-12) Preparation and characterization of a novel host-guest complex based on folate-modified β-cyclodextrin and artesunate.. Materials science & engineering. C, Materials for biological applications, 86 (48-55). [PMID:29525096] |
1. Qiuhui Hu, Bo Zhang, Huiming Ren, Xiaoxuan Zhou, Chengbin He, Youqing Shen, Zhuxian Zhou, Hongjie Hu. (2023) Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications. Acta Biomaterialia, 168 (617). [PMID:37482147] |
2. Pengfei Ren, Liuxin Yang, Dandan Wei, Min Liang, Li Xu, Tianzhu Zhang, Wanjun Hu, Zhigang Zhang, Qianli Zhang. (2023) Alginate/polyacrylamide host-guest supramolecular hydrogels with enhanced adhesion. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 242 (124885). [PMID:37196725] |
3. Lulu Han, Jiaxin Ji, Chong Zhang, Bingjian Sun, Zhenhua Chao, Hua Zhu, Xiaorong Gao, Jun Ren, Fangling Ji, Liming Ma, Lingyun Jia. (2023) One-Step Assembly of Versatile Multifunctional Coatings Based on Host-Guest and Polyphenol Chemistry. Small, 19 (22): (2206943). [PMID:36755211] |
4. Cheng Gao, Cheryl H. T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Simon Ming-Yuen Lee, Guosong Chen, Ruibing Wang. (2023) Conjugation of Macrophage-Mimetic Microalgae and Liposome for Antitumor Sonodynamic Immunotherapy via Hypoxia Alleviation and Autophagy Inhibition. ACS Nano, 17 (4): (4034–4049). [PMID:36739531] |
5. Yuan-Yuan Liu, Jie Liu, Hao Wu, Qiangqiang Zhang, Xue-Rui Tang, Dan Li, Chen-Si Li, Yuanfang Liu, Aoneng Cao, Haifang Wang. (2023) Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells. Nanomaterials, 13 (1): (84). [PMID:36615994] |
6. Tianyue Wu, Kefei Zhao, Chenhui Zhang, Tingjun Zhong, Zilu Li, Zhenping Bao, Yuxia Gao, Fengpei Du. (2022) Promising Delivery Platform for Smart Pest Control with High Water-Retaining Capacity. ACS Applied Materials & Interfaces, 14 (49): (55062–55074). [PMID:36472305] |
7. Tong Sun, Dong Hu, Zhizhang Guo, Hanwen Gong, Qiangwei Xin, Yandong Mu, Jie Weng, Jianshu Li, Xingyu Chen. (2023) Hexapeptide decorated β-cyclodextrin delivery system for targeted therapy of bone infection. JOURNAL OF CONTROLLED RELEASE, 353 (337). [PMID:36462641] |
8. Wenda Zhu, Yiping Fan, Yanbing Li, Lizhi Peng, Yifang Li, Fengxia Yan, Jiaqiang Zhao, Lei Zhang, Hiroshi Kurihara, Rongrong He, Heru Chen. (2023) Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects. BIOORGANIC CHEMISTRY, 130 (106223). [PMID:36356372] |
9. Junqing Shen, Ping Guan, Aiyun Jiang, Wentao Fan, Shengnan Li, Yingliang Liu, Shengang Xu, Shaokui Cao. (2022) A Polyanionic Strategy to Modify the Perovskite Grain Boundary for a Larger Switching Ratio in Flexible Woven Resistive Random-Access Memories. ACS Applied Materials & Interfaces, 14 (39): (44652–44664). [PMID:36125291] |
10. Jiaxin Zhao, Mingjuan Zhou, Yan Zhou, Danming Chao. (2022) Multi-stimuli-responsive color/fluorescence dual-switching behavior of a hyperbranched polyamidoamine bearing viologen and adamantane units. EUROPEAN POLYMER JOURNAL, 176 (111404). [PMID:] |
11. Pengfei Ren, Dandan Wei, Min Liang, Li Xu, Tianzhu Zhang, Qianli Zhang. (2022) Alginate/gelatin-based hybrid hydrogels with function of injecting and encapsulating cells in situ. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 212 (67). [PMID:35588977] |
12. Q. Wang, X. Yu, Y. Zhao, Y. Wang, K. Chen, Y. Liu, B. Wang, H. Zhang, Y. Sun. (2022) Friction-induced supramolecular nanovalves for the potential treatment of osteoarthritis. Materials Today Chemistry, 24 (100876). [PMID:] |
13. Song Zhu, Fei Luo, Bin Zhu, Fei Ling, Er-Long Wang, Tian-Qiang Liu, Gao-Xue Wang. (2021) A Nanobody-Mediated Virus-Targeting Drug Delivery Platform for the Central Nervous System Viral Disease Therapy. Microbiology Spectrum, 9 (3): [PMID:34817277] |
14. Rongqiang Liao,Shouhui Yi,Manshuo Liu,Wenling Jin,Bo Yang. (2015-06-03) Folic-Acid-Targeted Self-Assembling Supramolecular Carrier for Gene Delivery.. Chembiochem : a European journal of chemical biology, 16 ((11)): (1622-1628). [PMID:26032689] |
15. Dongjing Zhang,Cheng Zhou,Pin Lv,Yulin Zhao,Jing Liang,Xiali Liao,Bo Yang. (2018-03-12) Preparation and characterization of a novel host-guest complex based on folate-modified β-cyclodextrin and artesunate.. Materials science & engineering. C, Materials for biological applications, 86 (48-55). [PMID:29525096] |