1-Aminoisoquinoline - 97%, high purity , CAS No.1532-84-9

  • ≥97%
Item Number
A122683
Grouped product items
SKUSizeAvailabilityPrice Qty
A122683-1g
1g
In stock
$88.90
A122683-5g
5g
In stock
$397.90
A122683-25g
25g
In stock
$1,789.90

Basic Description

Synonyms1219805-83-0 | BDBM14320 | Nitriles, C10-16 | FT-0633643 | 1-amino isoquinoline | 1SQ | PD119379 | QUG12T52WZ | UNII-QUG12T52WZ | AC-907/25014244 | EN300-179397 | 2ohk | AM20050832 | aminoisoquinoline | isoquinolin-1-ylamine | isoquinolin-1-yl-amine | AKO
Specifications & Purity≥97%
Storage TempArgon charged
Shipped InNormal

Associated Targets(Human)

F7 Tchem Coagulation factor VII (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TEC Tchem Tyrosine-protein kinase Tec (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BACE1 Tchem Beta-secretase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLAU Tchem Urokinase-type plasminogen activator (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS2 Tchem Nitric oxide synthase, inducible (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS1 Tchem Nitric oxide synthase, brain (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS3 Tchem Nitric oxide synthase, endothelial (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NCF1 Tbio Neutrophil cytosol factor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PI4K2A Tbio Phosphatidylinositol 4-kinase type 2-alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NOS3 Tchem Nitric-oxide synthase, endothelial (1452 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLAU Tchem Urokinase-type plasminogen activator (2016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCF1 Tbio Neutrophil cytosol factor 1 (245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F7 Tchem Coagulation factor VII/tissue factor (740 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PI4K2A Tbio Phosphatidylinositol 4-kinase, PI4K (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tec Tyrosine-protein kinase TEC (25 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488184797
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184797
IUPAC Name isoquinolin-1-amine
INCHI InChI=1S/C9H8N2/c10-9-8-4-2-1-3-7(8)5-6-11-9/h1-6H,(H2,10,11)
InChi Key OSILBMSORKFRTB-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C=CN=C2N
Isomeric SMILES C1=CC=C2C(=C1)C=CN=C2N
WGK Germany 3
PubChem CID 73742
Molecular Weight 144.17
Reaxy-Rn 114480

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
C2302172Certificate of AnalysisMar 15, 2023 A122683
C2302166Certificate of AnalysisOct 25, 2022 A122683
L2208220Certificate of AnalysisOct 25, 2022 A122683
L2208227Certificate of AnalysisOct 25, 2022 A122683
I1819083Certificate of AnalysisJul 22, 2022 A122683
I1418036Certificate of AnalysisJul 11, 2022 A122683
B1420034Certificate of AnalysisFeb 14, 2022 A122683

Chemical and Physical Properties

SensitivityAir Sensitive
Boil Point(°C)166 °C/8 mmHg
Melt Point(°C)122-124°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
Reaxy-Rn 114480

Related Documents

References

1. J B Rewinkel,H Lucas,P J van Galen,A B Noach,T G van Dinther,A M Rood,A J Jenneboer,C A van Boeckel.  (1999-04-14)  1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors..  Bioorganic & medicinal chemistry letters,  ((5)): (685-690).  [PMID:10201829]
2. Cathleen Cover,Peter Fickert,Tamara R Knight,Andrea Fuchsbichler,Anwar Farhood,Michael Trauner,Hartmut Jaeschke.  (2004-12-17)  Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice..  Toxicological sciences : an official journal of the Society of Toxicology,  84  ((1)): (201-208).  [PMID:15601672]
3. Miles Congreve,Gianni Chessari,Dominic Tisi,Andrew J Woodhead.  (2008-05-07)  Recent developments in fragment-based drug discovery..  Journal of medicinal chemistry,  51  ((13)): (3661-3680).  [PMID:18457385]
4. Danqing Zheng,Zhiyuan Chen,Jianping Liu,Jie Wu.  (2011-05-28)  An efficient route to 1-aminoisoquinolines via AgOTf-catalyzed reaction of 2-alkynylbenzaldoxime with amine..  Organic & biomolecular chemistry,  ((13)): (4763-4765).  [PMID:21617812]
5. Xiaohong Wei,Miao Zhao,Zhengyin Du,Xingwei Li.  (2011-08-05)  Synthesis of 1-aminoisoquinolines via Rh(III)-catalyzed oxidative coupling..  Organic letters,  13  ((17)): (4636-4639).  [PMID:21812407]
6. S Giorgi-Renault,J Renault,P Servolles.  (1983-01-01)  [A practical method for the synthesis of 1-aminoisoquinoline]..  Annales pharmaceutiques francaises,  41  ((6)): (555-557).  [PMID:6677167]
7. Hervé Bibas,Daniel W J Moloney,Ralf Neumann,Majed Shtaiwi,Paul V Bernhardt,Curt Wentrup.  (2002-04-13)  Chemistry of stable iminopropadienones, RN=C=C=C=O..  The Journal of organic chemistry,  67  ((8)): (2619-2631).  [PMID:11950308]
8. Scott P Brown,Steven W Muchmore.  (2009-04-24)  Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes..  Journal of medicinal chemistry,  52  ((10)): (3159-3165).  [PMID:19385614]
9. Adrian L Smith,Frenel F DeMorin,Nick A Paras,Qi Huang,Jeffrey K Petkus,Elizabeth M Doherty,Thomas Nixey,Joseph L Kim,Douglas A Whittington,Linda F Epstein,Matthew R Lee,Mark J Rose,Carol Babij,Manory Fernando,Kristen Hess,Quynh Le,Pedro Beltran,Josette Carnahan.  (2009-09-22)  Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline..  Journal of medicinal chemistry,  52  ((20)): (6189-6192).  [PMID:19764794]

Solution Calculators