JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Home
Applications
Targets
G protein-coupled receptors (GPCRs)
Calcium-sensing receptor
1-arylmethylpyrrolidin-2-yl ethanol amine , CAS No.A607083, Antagonist of CaS receptor

1-arylmethylpyrrolidin-2-yl ethanol amine , CAS No.A607083, Antagonist of CaS receptor

Item Number

A607083

Grouped product items
SKU	Size	Availability	Price	Qty
A607083-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607083-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,900.90

View related series

Basic Description

CASR Tclin Extracellular calcium-sensing receptor (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	3-{[(2R)-2-[(1R)-2-{[1-(1-benzothiophen-2-yl)-2-methylpropan-2-yl]amino}-1-hydroxyethyl]pyrrolidin-1-yl]methyl}benzonitrile
INCHI	InChI=1S/C26H31N3OS/c1-26(2,15-22-14-21-9-3-4-11-25(21)31-22)28-17-24(30)23-10-6-12-29(23)18-20-8-5-7-19(13-20)16-27/h3-5,7-9,11,13-14,23-24,28,30H,6,10,12,15,17-18H2,1-2H3/t23-,24-/m1/s1
InChi Key	HCLQARMRCPEALF-DNQXCXABSA-N
Canonical SMILES	N#Cc1cccc(c1)CN1CCC[C@@H]1[C@@H](CNC(Cc1cc2c(s1)cccc2)(C)C)O
Isomeric SMILES	CC(C)(CC1=CC2=CC=CC=C2S1)NC[C@H]([C@H]3CCCN3CC4=CC(=CC=C4)C#N)O
PubChem CID	44405854

PubChem CID	44405854
ChEMBL Ligand	CHEMBL200312
BindingDB Ligand	50175363
GPCRdb Ligand	1-arylmethylpyrrolidin-2-yl ethanol amine

Enter Lot Number to search for COA:

1. Gavai AV, Vaz RJ, Mikkilineni AB, Roberge JY, Liu Y, Lawrence RM, Corte JR, Yang W, Bednarz M, Dickson Jr JK et al.. (2005) Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.. Bioorg Med Chem Lett, 15 (24): (5478-82). [PMID:16216508] [10.1021/op500134e]

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.