1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether - >98.0%(GC), high purity , Potassium channel subfamily K member 2 opener, CAS No.26675-46-7, Potassium channel subfamily K member 2 opener

Item Number
C153359
Grouped product items
SKUSizeAvailabilityPrice Qty
C153359-1g
1g
In stock
$9.90
C153359-5g
5g
In stock
$34.90
C153359-25g
25g
In stock
$132.90
C153359-100g
100g
In stock
$277.90
C153359-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,111.90

Anesthetic agent. Induces apoptosis and amyloid β-protein accumulation.

Basic Description

SynonymsBBL100111 | SY050218 | A818554 | CAS-26675-46-7 | Isoflurano [INN-Spanish] | IsoSol | STL454337 | TerrellHSDB 8057 | C2485 | ISOFLURANE (EP MONOGRAPH) | CHEBI:6015 | HSDB-8057 | N01AB06 | NCGC00181037-02 | ATTANE | Compound 469 | Ethane, 2-chloro-2-(diflu
Specifications & PurityMoligand™, ≥98%(GC)
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeACTIVATOR, POSITIVE MODULATOR
Mechanism of actionPotassium channel subfamily K member 2 opener
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Used only for R&D experiments

Product Properties

ALogP2.1

Associated Targets(Human)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK2 Tclin Potassium channel subfamily K member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK3 Tclin Potassium channel subfamily K member 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK16 Tbio Potassium channel subfamily K member 16 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Kcnk3 Potassium channel subfamily K member 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488179792
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179792
IUPAC Name 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
INCHI InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
InChi Key PIWKPBJCKXDKJR-UHFFFAOYSA-N
Canonical SMILES C(C(F)(F)F)(OC(F)F)Cl
Isomeric SMILES C(C(F)(F)F)(OC(F)F)Cl
RTECS KN6799000
PubChem CID 3763
Molecular Weight 184.49
Reaxy-Rn 1852087

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

29 results found

Lot NumberCertificate TypeDateItem
K2404167Certificate of AnalysisOct 24, 2024 C153359
K2404166Certificate of AnalysisOct 24, 2024 C153359
K2404165Certificate of AnalysisOct 24, 2024 C153359
K2404153Certificate of AnalysisOct 24, 2024 C153359
K2404152Certificate of AnalysisOct 24, 2024 C153359
F2417168Certificate of AnalysisJun 04, 2024 C153359
F2417170Certificate of AnalysisJun 04, 2024 C153359
F2417169Certificate of AnalysisJun 04, 2024 C153359
F2417167Certificate of AnalysisJun 04, 2024 C153359
F2417166Certificate of AnalysisJun 04, 2024 C153359
F2417154Certificate of AnalysisJun 04, 2024 C153359
B2028066Certificate of AnalysisDec 14, 2023 C153359
C23101292Certificate of AnalysisMar 22, 2023 C153359
B2309276Certificate of AnalysisFeb 14, 2023 C153359
B2309272Certificate of AnalysisFeb 14, 2023 C153359
B2309305Certificate of AnalysisFeb 14, 2023 C153359
I2220218Certificate of AnalysisJul 20, 2022 C153359
K2330172Certificate of AnalysisJul 20, 2022 C153359
I2220220Certificate of AnalysisJul 20, 2022 C153359
I2220219Certificate of AnalysisJul 20, 2022 C153359
I2220217Certificate of AnalysisJul 20, 2022 C153359
I2220216Certificate of AnalysisJul 20, 2022 C153359
C2414054Certificate of AnalysisJul 20, 2022 C153359
H1823083Certificate of AnalysisJun 22, 2022 C153359
F2307074Certificate of AnalysisFeb 23, 2022 C153359
C2223485Certificate of AnalysisFeb 23, 2022 C153359
C2223483Certificate of AnalysisFeb 23, 2022 C153359
C2223492Certificate of AnalysisFeb 23, 2022 C153359
C2223493Certificate of AnalysisFeb 23, 2022 C153359

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Chemical and Physical Properties

SolubilitySoluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.
Refractive Index1.302
Boil Point(°C)48-49℃

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H336:May cause drowsiness or dizziness

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P319:Get medical help if you feel unwell.

RTECS KN6799000
Reaxy-Rn 1852087
Merck Index 5175

Related Documents

Citations of This Product

1. Shuanghui Lu, Xiu Chen, Yujia Chen, Yingqiong Zhang, Jun Luo, Huidi Jiang, Luo Fang, Hui Zhou.  (2023)  Downregulation of PDZK1 by TGF-β1 promotes renal fibrosis via inducing epithelial-mesenchymal transition of renal tubular cells.  BIOCHEMICAL PHARMACOLOGY,    (116015).  [PMID:38158021] [10.1016/j.bcp.2023.116015]
2. Ruiqing Zhou, Chengqing Huang, Nanxi Bi, Ling Li, Changqing Li, Xiaozhen Gu, Yang Song, Hui-Li Wang.  (2023)  Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:37559393] [10.1021/acs.est.3c03426]
3. Xiao Zhang, Yating Ma, Xiaojian Zhang, Xin Pang, Zhiheng Yang.  (2023)  Bio-inspired self-assembled bacteriochlorin nanoparticles for superior visualization and photothermal ablation of tumors.  BIOMEDICINE & PHARMACOTHERAPY,  165  (115014).  [PMID:37327585] [10.1016/j.biopha.2023.115014]
4. Zhuang Kejin, Meng Weihong, Shu Xin, Liang Defu, Wang Lidong, Zhang Dongjie.  (2023)  Fecal metabonomics combined with 16S rDNA sequencing to analyze the changes of gut microbiota in rats fed with different protein source diets.  EUROPEAN JOURNAL OF NUTRITION,  62  (6): (2687-2703).  [PMID:37273002] [10.1007/s00394-023-03168-y]
5. Rongrong Wang, Zhi-Hua Liu, Nanxi Bi, Xiaozhen Gu, Chengqing Huang, Ruiqing Zhou, Haoyu Liu, Hui-Li Wang.  (2023)  Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression- and anxiety-like behavior in mice.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  259  (115034).  [PMID:37210999] [10.1016/j.ecoenv.2023.115034]
6. Haibo Du, Lianqin Ding, Tian Zeng, Di Li, Li Liu.  (2022)  LncRNA SNHG15 Modulates Ischemia-Reperfusion Injury in Human AC16 Cardiomyocytes Depending on the Regulation of the miR-335-3p/TLR4/NF-κB Pathway.  International Heart Journal,  63  (3): (578-590).  [PMID:] [10.1536/ihj.21-511]
7. Wang Fei, Li Wu-lin, Shen Li-juan, Jiang Ting-ting, Xia Jian-jun, You Da-li, Hu Shan-you, Wang Li, Wu Xiao.  (2022)  Crocin Alleviates Intracerebral Hemorrhage–Induced Neuronal Ferroptosis by Facilitating Nrf2 Nuclear Translocation.  NEUROTOXICITY RESEARCH,  40  (2): (596-604).  [PMID:35380368] [10.1007/s12640-022-00500-y]
8. Huang Yuxing, Deng Lisha, Zeng Lin, Bao Shanlin, Ye Kun, Li Chengxun, Hou Xiaolin, Yao Yuan, Li Dingjun, Xiong Zhen.  (2021)  Silencing of H19 alleviates oxygen–glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis.  METABOLIC BRAIN DISEASE,  36  (8): (2461-2472).  [PMID:34436746] [10.1007/s11011-021-00822-4]
9. Haijuan Hu, Shanshan Zhang, Fengxia Liu, Peipei Zhang, Zafarullah Muhammad, Siyi Pan.  (2019)  Role of the Gut Microbiota and Their Metabolites in Modulating the Cholesterol-Lowering Effects of Citrus Pectin Oligosaccharides in C57BL/6 Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  67  (43): (11922–11930).  [PMID:31576748] [10.1021/acs.jafc.9b03731]

References

1. Wilson C et al..  (2020)  Protocol for Evaluating Neuronal Polarity in Murine Models..  STAR Protoc,  (3): (100114).  [PMID:33377010]
2. Shuanghui Lu, Xiu Chen, Yujia Chen, Yingqiong Zhang, Jun Luo, Huidi Jiang, Luo Fang, Hui Zhou.  (2023)  Downregulation of PDZK1 by TGF-β1 promotes renal fibrosis via inducing epithelial-mesenchymal transition of renal tubular cells.  BIOCHEMICAL PHARMACOLOGY,    (116015).  [PMID:38158021] [10.1016/j.bcp.2023.116015]
3. Ruiqing Zhou, Chengqing Huang, Nanxi Bi, Ling Li, Changqing Li, Xiaozhen Gu, Yang Song, Hui-Li Wang.  (2023)  Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:37559393] [10.1021/acs.est.3c03426]
4. Xiao Zhang, Yating Ma, Xiaojian Zhang, Xin Pang, Zhiheng Yang.  (2023)  Bio-inspired self-assembled bacteriochlorin nanoparticles for superior visualization and photothermal ablation of tumors.  BIOMEDICINE & PHARMACOTHERAPY,  165  (115014).  [PMID:37327585] [10.1016/j.biopha.2023.115014]
5. Zhuang Kejin, Meng Weihong, Shu Xin, Liang Defu, Wang Lidong, Zhang Dongjie.  (2023)  Fecal metabonomics combined with 16S rDNA sequencing to analyze the changes of gut microbiota in rats fed with different protein source diets.  EUROPEAN JOURNAL OF NUTRITION,  62  (6): (2687-2703).  [PMID:37273002] [10.1007/s00394-023-03168-y]
6. Rongrong Wang, Zhi-Hua Liu, Nanxi Bi, Xiaozhen Gu, Chengqing Huang, Ruiqing Zhou, Haoyu Liu, Hui-Li Wang.  (2023)  Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression- and anxiety-like behavior in mice.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  259  (115034).  [PMID:37210999] [10.1016/j.ecoenv.2023.115034]
7. Haibo Du, Lianqin Ding, Tian Zeng, Di Li, Li Liu.  (2022)  LncRNA SNHG15 Modulates Ischemia-Reperfusion Injury in Human AC16 Cardiomyocytes Depending on the Regulation of the miR-335-3p/TLR4/NF-κB Pathway.  International Heart Journal,  63  (3): (578-590).  [PMID:] [10.1536/ihj.21-511]
8. Wang Fei, Li Wu-lin, Shen Li-juan, Jiang Ting-ting, Xia Jian-jun, You Da-li, Hu Shan-you, Wang Li, Wu Xiao.  (2022)  Crocin Alleviates Intracerebral Hemorrhage–Induced Neuronal Ferroptosis by Facilitating Nrf2 Nuclear Translocation.  NEUROTOXICITY RESEARCH,  40  (2): (596-604).  [PMID:35380368] [10.1007/s12640-022-00500-y]
9. Huang Yuxing, Deng Lisha, Zeng Lin, Bao Shanlin, Ye Kun, Li Chengxun, Hou Xiaolin, Yao Yuan, Li Dingjun, Xiong Zhen.  (2021)  Silencing of H19 alleviates oxygen–glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis.  METABOLIC BRAIN DISEASE,  36  (8): (2461-2472).  [PMID:34436746] [10.1007/s11011-021-00822-4]
10. Haijuan Hu, Shanshan Zhang, Fengxia Liu, Peipei Zhang, Zafarullah Muhammad, Siyi Pan.  (2019)  Role of the Gut Microbiota and Their Metabolites in Modulating the Cholesterol-Lowering Effects of Citrus Pectin Oligosaccharides in C57BL/6 Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  67  (43): (11922–11930).  [PMID:31576748] [10.1021/acs.jafc.9b03731]

Solution Calculators