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1-Chloro-3-nitrobenzene - Guaranteed Reagent,99%, high purity , CAS No.121-73-3

22 Citations

≥99%

CAS#: 121-73-3
Formula: C₆H₄ClNO₂
Molecular Weight: 157.55
Beilstein Registry Number: 1907947
EC Number: 204-496-1
MDL number: MFCD00007202
PubChem CID: 8489

Item Number

C100475

Grouped product items
SKU	Size	Availability	Price
C100475-25g	25g	In stock	$35.90
C100475-100g	100g	In stock	$69.90
C100475-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$223.90

Basic Description

Synonyms	BENZENE, 1-CHLORO-3-NITRO- \| DTXSID4021971 \| 1-Chloro-3-nitrobenzene, 95% \| 1-Nitro-3-chlorobenzene \| Chloronitrobenzenes meta or para, solid [UN1578] [Poison] \| 1-Chloro-3-nitrobenzene, analytical standard \| Metachloronitrobenzene \| meta-chloronitrobenz
Specifications & Purity	GR, ≥99%
Storage Temp	Room temperature
Shipped In	Normal
Grade	GR
Product Description	1-Chloro-3-nitrobenzene was used in the preparation of aromatic azo compounds using gold (Au) nanoparticles supported on TiO2 as a catalyst.It was also used as surrogate standard to evaluate the removal of 2,4-dinitrotoluene from contaminated soils using enhanced electrokinetic remediation.

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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AR Tclin Androgen receptor (0 Activities)

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ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)

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CXCL8 Tchem Interleukin-8 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen Receptor (11781 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CXCL8 Tchem Interleukin-8 (642 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Salmonella typhimurium (15756 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-chloro-3-nitrobenzene
INCHI	InChI=1S/C6H4ClNO2/c7-5-2-1-3-6(4-5)8(9)10/h1-4H
InChi Key	KMAQZIILEGKYQZ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC(=C1)Cl)[N+](=O)[O-]
Isomeric SMILES	C1=CC(=CC(=C1)Cl)[N+](=O)[O-]
WGK Germany	3
RTECS	CZ0940000
PubChem CID	8489
UN Number	1578
Packing Group	II
Molecular Weight	157.55
Beilstein	1907947

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
B2309114	Certificate of Analysis	Feb 16, 2023	C100475
B2309115	Certificate of Analysis	Feb 14, 2023	C100475
E1831015	Certificate of Analysis	Apr 12, 2022	C100475
F2302914	Certificate of Analysis	Apr 12, 2022	C100475

Chemical and Physical Properties

Solubility	Soluble in hot ethanol, chloroform, ether, carbon disulfide and glacial acetic acid, slightly soluble in cold ethanol, insoluble in water
Flash Point(°F)	103℃
Flash Point(°C)	103℃
Boil Point(°C)	236°C
Melt Point(°C)	46°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS09
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled H351:Suspected of causing cancer H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H317:May cause an allergic skin reaction H400:Very toxic to aquatic life H372:Causes damage to organs through prolonged or repeated exposure
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	CZ0940000
Class	6.1
Merck Index	2151

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hongbo Yu, Shuibo Wang, Lin Zhu, Chunzheng Wu. (2024) One-pot synthesis of Pt@Sn core-shell nanocatalysts for the hydrogenation of halonitrobenzene to produce haloaniline with ultra-high selectivity. APPLIED SURFACE SCIENCE, 643 (158729). [PMID:17548428] [10.1016/j.apsusc.2023.158729]
2. Jiasheng Wang, Ying Zhang, Xiaonan Xu, Ming Bao. (2023) Oxygen Vacancy-Rich Ni–CeO2 Heterojunction Catalyst for Hydrogenating Halogenated Nitroarenes with High Activity and Selectivity. ACS Applied Materials & Interfaces, 15 (6): (8149–8156). [PMID:36637974] [10.1021/acsami.2c21272]
3. Ziqi Sun, Meiling Qi. (2022) High separation performance of carbon dioxide-based poly(ether-carbonate) copolymer for gas chromatographic analyses. JOURNAL OF CHROMATOGRAPHY A, 1682 (463493). [PMID:36166885] [10.1016/j.chroma.2022.463493]
4. Fan Yang, Hongbo Yu, Chunzheng Wu, Shiwei Wang, Tong Li, Hongfeng Yin. (2022) RhCu Bimetallic Nanoparticles in Hollow Carbon Spheres for Catalytic Halonitrobenzene Chemoselective Hydrogenation. ACS Applied Nano Materials, 5 (8): (11627–11635). [PMID:] [10.1021/acsanm.2c02358]
5. Yebin Zhou, Ling Li, Yi Liu, Hongzheng Wang, Zhenlong Feng, Feng Feng, Qunfeng Zhang, Wucan Liu, Wenfeng Han, Chunshan Lu, Xiaonian Li. (2022) Palladium Nanoparticles Inset into the Carbon Sphere with Robust Acid Resistance for Selective Hydrogenation of Chloronitrobenzene. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 61 (12): (4310–4319). [PMID:] [10.1021/acs.iecr.1c04983]
6. Hongbo Yu, Chunzheng Wu, Shiwei Wang, Tong Li, Hongfeng Yin. (2021) Transition Metal Oxide-Modified Ir Nanoparticles Supported on SBA-15 Silica for Selective Hydrogenation of Substituted Nitroaromatics. ACS Applied Nano Materials, 4 (7): (7213–7220). [PMID:] [10.1021/acsanm.1c01164]
7. Peng Zhang, Shaonan Xu, Yan Wang, Wei Zhang, Wenqing Li, Cundi Wei, Peiping Zhang, Shiding Miao. (2021) Fabrication of Pd/Mg2P2O7 via a Struvite-Template Way from Wastewater and Application as Chemoselective Catalyst in Hydrogenation of Nitroarenes. CHEMISTRY-A EUROPEAN JOURNAL, 27 (41): (10666-10676). [PMID:34009699] [10.1002/chem.202100684]
8. Zechen Liang, Mingkai Zhang, Sai Zhang, Yongquan Qu. (2021) Electron-Enriched Pd Nanoparticles for Selective Hydrogenation of Halonitrobenzenes to Haloanilines. Catalysts, 11 (5): (543). [PMID:] [10.3390/catal11050543]
9. Wei Lang, Gengjinsheng Cheng, Rongpeng Peng, Qian-Yong Cao. (2021) Rhodamine-anchored poly(norbornene) for fluorescent sensing of ATP. DYES AND PIGMENTS, 189 (109245). [PMID:] [10.1016/j.dyepig.2021.109245]
10. Pengchao Chen, Kaijie Li, Peijian Yan, Junyou Wang, Shenghu Zhou. (2021) Pd–FexOy Hybrid Nanoparticles Encaged Hollow Mesoporous Silica Nanoreactors for Reduction of Nitroarenes to Aminoarenes. Journal of Physical Chemistry C, 125 (7): (4001–4009). [PMID:] [10.1021/acs.jpcc.0c11161]
11. Yingzhang Shi, Huan Wang, Zhiwen Wang, Taikang Wu, Yujie Song, Binbin Guo, Ling Wu. (2020) Pt decorated hierarchical Sb2WO6 microspheres as a surface functionalized photocatalyst for the visible-light-driven reduction of nitrobenzene to aniline. Journal of Materials Chemistry A, 8 (36): (18755-18766). [PMID:] [10.1039/D0TA06099B]
12. Xue Xiong, Meiling Qi. (2020) A novel column fabrication approach for capillary gas chromatography via a cross-linked organogel network with high stability and inertness. NEW JOURNAL OF CHEMISTRY, 44 (25): (10621-10627). [PMID:] [10.1039/D0NJ02185G]
13. Yueling Cao, Kangkai Liu, Chen Wu, Hepeng Zhang, Qiuyu Zhang. (2020) In situ-formed cobalt embedded into N-doped carbon as highly efficient and selective catalysts for the hydrogenation of halogenated nitrobenzenes under mild conditions. APPLIED CATALYSIS A-GENERAL, 592 (117434). [PMID:] [10.1016/j.apcata.2020.117434]
14. Qiuyang Zhang, Caiyun Xu, Hongfeng Yin, Shenghu Zhou. (2019) Enhanced Catalytic Hydrogenation Performance of Rh-Co2O3 Heteroaggregate Nanostructures by in Situ Transformation of Rh@Co Core–Shell Nanoparticles. ACS Omega, 4 (24): (20829–20837). [PMID:31858069] [10.1021/acsomega.9b03340]
15. Hongbo Yu, Weiqiang Tang, Kaijie Li, Shuangliang Zhao, Hongfeng Yin, Shenghu Zhou. (2019) Enhanced Catalytic Performance for Hydrogenation of Substituted Nitroaromatics over Ir-Based Bimetallic Nanocatalysts. ACS Applied Materials & Interfaces, 11 (7): (6958–6969). [PMID:30674185] [10.1021/acsami.8b19056]
16. Hongbo Yu, Weiqiang Tang, Kaijie Li, Hongfeng Yin, Shuangliang Zhao, Shenghu Zhou. (2019) Design of Cu-based intermetallic nanocrystals for enhancing hydrogenation selectivity. CHEMICAL ENGINEERING SCIENCE, 196 (402). [PMID:] [10.1016/j.ces.2018.11.024]
17. Dongxing Zhen, Gaohong He, Xinlong Xu, Xiaoming Yan, Naixu Du, Xue Gong, Tiantian Li, Yan Dai, Xuemei Wu. (2018) Simultaneous enhancement of proton conductivity and methanol resistance of sulfonated poly(phthalazinone ether sulfone ketone)/superacid sulfated zirconia composite membranes for direct methanol fuel cells. JOURNAL OF APPLIED POLYMER SCIENCE, 135 (42): (46758). [PMID:] [10.1002/app.46758]
18. Yanlong Chen, Wenfen Zhang, Yanhao Zhang, Zhifen Deng, Wenjie Zhao, Huifang Du, Xue Ma, Dan Yin, Fuwei Xie, Yu Chen, Shusheng Zhang. (2018) In situ preparation of core–shell magnetic porous aromatic framework nanoparticles for mixed–mode solid–phase extraction of trace multitarget analytes. JOURNAL OF CHROMATOGRAPHY A, 1556 (1). [PMID:29735279] [10.1016/j.chroma.2018.04.039]
19. Miaomiao Liu, Weiqiang Tang, Zhaohui Xie, Hongbo Yu, Hongfeng Yin, Yisheng Xu, Shuangliang Zhao, Shenghu Zhou. (2017) Design of Highly Efficient Pt-SnO2 Hydrogenation Nanocatalysts using Pt@Sn Core–Shell Nanoparticles. ACS Catalysis, 7 (3): (1583–1591). [PMID:] [10.1021/acscatal.6b03109]
20. Xinhuan Lu, Yang chen, Zhenshuang Zhao, Hao Deng, Dan Zhou, Changcheng Wei, Renfeng Nie, Qinghua Xia. (2016) Highly selective one-step hydrogenation of nitrobenzene to cyclohexylamine over the supported 10% Ni/carbon catalysts doped with 3‰ Rh. RSC Advances, 6 (19): (15354-15361). [PMID:] [10.1039/C5RA27202E]
21. Liu Wen-na, Fan Jun, Lin Chun, Zheng Sheng-run, Zhang Wei-guang. (2014) Synthesis of a New Cyclosporine-based Stationary Phase and Separation Behaviors toward Aromatic Positional Isomers by High-Performance Liquid Chromatography. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 53 (4): (548-553). [PMID:25038034] [10.1093/chromsci/bmu083]
22. Xue Xiong,Meiling Qi. (2018-08-14) Hexagonal boron nitride stationary phase for gas chromatography.. Journal of chromatography. A, 1567 (191-197). [PMID:30100014]

References

1. Hongbo Yu, Shuibo Wang, Lin Zhu, Chunzheng Wu. (2024) One-pot synthesis of Pt@Sn core-shell nanocatalysts for the hydrogenation of halonitrobenzene to produce haloaniline with ultra-high selectivity. APPLIED SURFACE SCIENCE, 643 (158729). [PMID:17548428] [10.1016/j.apsusc.2023.158729]
2. Jiasheng Wang, Ying Zhang, Xiaonan Xu, Ming Bao. (2023) Oxygen Vacancy-Rich Ni–CeO2 Heterojunction Catalyst for Hydrogenating Halogenated Nitroarenes with High Activity and Selectivity. ACS Applied Materials & Interfaces, 15 (6): (8149–8156). [PMID:36637974] [10.1021/acsami.2c21272]
3. Ziqi Sun, Meiling Qi. (2022) High separation performance of carbon dioxide-based poly(ether-carbonate) copolymer for gas chromatographic analyses. JOURNAL OF CHROMATOGRAPHY A, 1682 (463493). [PMID:36166885] [10.1016/j.chroma.2022.463493]
4. Fan Yang, Hongbo Yu, Chunzheng Wu, Shiwei Wang, Tong Li, Hongfeng Yin. (2022) RhCu Bimetallic Nanoparticles in Hollow Carbon Spheres for Catalytic Halonitrobenzene Chemoselective Hydrogenation. ACS Applied Nano Materials, 5 (8): (11627–11635). [PMID:] [10.1021/acsanm.2c02358]
5. Yebin Zhou, Ling Li, Yi Liu, Hongzheng Wang, Zhenlong Feng, Feng Feng, Qunfeng Zhang, Wucan Liu, Wenfeng Han, Chunshan Lu, Xiaonian Li. (2022) Palladium Nanoparticles Inset into the Carbon Sphere with Robust Acid Resistance for Selective Hydrogenation of Chloronitrobenzene. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 61 (12): (4310–4319). [PMID:] [10.1021/acs.iecr.1c04983]
6. Hongbo Yu, Chunzheng Wu, Shiwei Wang, Tong Li, Hongfeng Yin. (2021) Transition Metal Oxide-Modified Ir Nanoparticles Supported on SBA-15 Silica for Selective Hydrogenation of Substituted Nitroaromatics. ACS Applied Nano Materials, 4 (7): (7213–7220). [PMID:] [10.1021/acsanm.1c01164]
7. Peng Zhang, Shaonan Xu, Yan Wang, Wei Zhang, Wenqing Li, Cundi Wei, Peiping Zhang, Shiding Miao. (2021) Fabrication of Pd/Mg2P2O7 via a Struvite-Template Way from Wastewater and Application as Chemoselective Catalyst in Hydrogenation of Nitroarenes. CHEMISTRY-A EUROPEAN JOURNAL, 27 (41): (10666-10676). [PMID:34009699] [10.1002/chem.202100684]
8. Zechen Liang, Mingkai Zhang, Sai Zhang, Yongquan Qu. (2021) Electron-Enriched Pd Nanoparticles for Selective Hydrogenation of Halonitrobenzenes to Haloanilines. Catalysts, 11 (5): (543). [PMID:] [10.3390/catal11050543]
9. Wei Lang, Gengjinsheng Cheng, Rongpeng Peng, Qian-Yong Cao. (2021) Rhodamine-anchored poly(norbornene) for fluorescent sensing of ATP. DYES AND PIGMENTS, 189 (109245). [PMID:] [10.1016/j.dyepig.2021.109245]
10. Pengchao Chen, Kaijie Li, Peijian Yan, Junyou Wang, Shenghu Zhou. (2021) Pd–FexOy Hybrid Nanoparticles Encaged Hollow Mesoporous Silica Nanoreactors for Reduction of Nitroarenes to Aminoarenes. Journal of Physical Chemistry C, 125 (7): (4001–4009). [PMID:] [10.1021/acs.jpcc.0c11161]
11. Yingzhang Shi, Huan Wang, Zhiwen Wang, Taikang Wu, Yujie Song, Binbin Guo, Ling Wu. (2020) Pt decorated hierarchical Sb2WO6 microspheres as a surface functionalized photocatalyst for the visible-light-driven reduction of nitrobenzene to aniline. Journal of Materials Chemistry A, 8 (36): (18755-18766). [PMID:] [10.1039/D0TA06099B]
12. Xue Xiong, Meiling Qi. (2020) A novel column fabrication approach for capillary gas chromatography via a cross-linked organogel network with high stability and inertness. NEW JOURNAL OF CHEMISTRY, 44 (25): (10621-10627). [PMID:] [10.1039/D0NJ02185G]
13. Yueling Cao, Kangkai Liu, Chen Wu, Hepeng Zhang, Qiuyu Zhang. (2020) In situ-formed cobalt embedded into N-doped carbon as highly efficient and selective catalysts for the hydrogenation of halogenated nitrobenzenes under mild conditions. APPLIED CATALYSIS A-GENERAL, 592 (117434). [PMID:] [10.1016/j.apcata.2020.117434]
14. Qiuyang Zhang, Caiyun Xu, Hongfeng Yin, Shenghu Zhou. (2019) Enhanced Catalytic Hydrogenation Performance of Rh-Co2O3 Heteroaggregate Nanostructures by in Situ Transformation of Rh@Co Core–Shell Nanoparticles. ACS Omega, 4 (24): (20829–20837). [PMID:31858069] [10.1021/acsomega.9b03340]
15. Hongbo Yu, Weiqiang Tang, Kaijie Li, Shuangliang Zhao, Hongfeng Yin, Shenghu Zhou. (2019) Enhanced Catalytic Performance for Hydrogenation of Substituted Nitroaromatics over Ir-Based Bimetallic Nanocatalysts. ACS Applied Materials & Interfaces, 11 (7): (6958–6969). [PMID:30674185] [10.1021/acsami.8b19056]
16. Hongbo Yu, Weiqiang Tang, Kaijie Li, Hongfeng Yin, Shuangliang Zhao, Shenghu Zhou. (2019) Design of Cu-based intermetallic nanocrystals for enhancing hydrogenation selectivity. CHEMICAL ENGINEERING SCIENCE, 196 (402). [PMID:] [10.1016/j.ces.2018.11.024]
17. Dongxing Zhen, Gaohong He, Xinlong Xu, Xiaoming Yan, Naixu Du, Xue Gong, Tiantian Li, Yan Dai, Xuemei Wu. (2018) Simultaneous enhancement of proton conductivity and methanol resistance of sulfonated poly(phthalazinone ether sulfone ketone)/superacid sulfated zirconia composite membranes for direct methanol fuel cells. JOURNAL OF APPLIED POLYMER SCIENCE, 135 (42): (46758). [PMID:] [10.1002/app.46758]
18. Yanlong Chen, Wenfen Zhang, Yanhao Zhang, Zhifen Deng, Wenjie Zhao, Huifang Du, Xue Ma, Dan Yin, Fuwei Xie, Yu Chen, Shusheng Zhang. (2018) In situ preparation of core–shell magnetic porous aromatic framework nanoparticles for mixed–mode solid–phase extraction of trace multitarget analytes. JOURNAL OF CHROMATOGRAPHY A, 1556 (1). [PMID:29735279] [10.1016/j.chroma.2018.04.039]
19. Miaomiao Liu, Weiqiang Tang, Zhaohui Xie, Hongbo Yu, Hongfeng Yin, Yisheng Xu, Shuangliang Zhao, Shenghu Zhou. (2017) Design of Highly Efficient Pt-SnO2 Hydrogenation Nanocatalysts using Pt@Sn Core–Shell Nanoparticles. ACS Catalysis, 7 (3): (1583–1591). [PMID:] [10.1021/acscatal.6b03109]
20. Xinhuan Lu, Yang chen, Zhenshuang Zhao, Hao Deng, Dan Zhou, Changcheng Wei, Renfeng Nie, Qinghua Xia. (2016) Highly selective one-step hydrogenation of nitrobenzene to cyclohexylamine over the supported 10% Ni/carbon catalysts doped with 3‰ Rh. RSC Advances, 6 (19): (15354-15361). [PMID:] [10.1039/C5RA27202E]
21. Liu Wen-na, Fan Jun, Lin Chun, Zheng Sheng-run, Zhang Wei-guang. (2014) Synthesis of a New Cyclosporine-based Stationary Phase and Separation Behaviors toward Aromatic Positional Isomers by High-Performance Liquid Chromatography. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 53 (4): (548-553). [PMID:25038034] [10.1093/chromsci/bmu083]
22. Xue Xiong,Meiling Qi. (2018-08-14) Hexagonal boron nitride stationary phase for gas chromatography.. Journal of chromatography. A, 1567 (191-197). [PMID:30100014]

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