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1-Deoxynojirimycin - analytical standard,≥98%, high purity , CAS No.19130-96-2, Inhibitor of alpha glucosidase

3 Citations

analytical standard

Moligand™

≥98%

CAS#: 19130-96-2
Formula: C₆H₁₃NO₄
Molecular Weight: 163.17
PubChem CID: 29435

Item Number

D101242

Grouped product items
SKU	Size	Availability	Price
D101242-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$343.90
D101242-20mg	20mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$515.90
D101242-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,026.90
D101242-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,527.90

Potent α-glycosidase inhibitor. Antihyperglycemic agent.

View related series

alpha glucosidase Inhibitor

Basic Description

Synonyms	1-DEOXYNOJIRIMYCIN \| 19130-96-2 \| DUVOGLUSTAT \| Moranoline \| deoxynojirimycin \| (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol \| Moranolin \| 1 Deoxynojirimycin \| 1,5-Deoxy-1,5-imino-D-mannitol \| D-1-deoxynojirimycin \| 1,5-Dideoxy-1,5-imino-D-glucitol \| (+)-1-DEOXYNOJIRI
Specifications & Purity	Moligand™, analytical standard, ≥98%
Biochemical and Physiological Mechanisms	Potent α-glycosidase inhibitor (IC 50 = 30 nM). Antihyperglycemic agent. Downregulates SGLT1, Na + /K + -ATP and GLUT2 expression. Decreases MCP-1 and TNF-α levels. Shows antidiabetic, antiviral, antiobesity and anti-inflammatory effects in vivo. Orally a
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	analytical standard, Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of alpha glucosidase
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Deoxynojirimycin is a Maltase-glucoamylase (α-glucosidase I and II) inhibitor. Interferes with N-linked glycosylation. Reported to inhibit trimming of oligosaccharides upon treatment of secretory glycoprotein IgD- and IgM-producing cells. Reported to inhibit secretion of IgD. Deoxynojirimycin is an inhibitor of β-glucosidase and Maltase-glucoamylase. An inhibitor of α-glucosidase I and II

Associated Targets(Human)

GAA Tclin Lysosomal alpha-glucosidase (4 Activities)

Discover Target: GAA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGAM Tclin Maltase-glucoamylase, intestinal (2 Activities)

Discover Target: MGAM

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GANAB Tchem Neutral alpha-glucosidase AB (2 Activities)

Discover Target: GANAB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGAM Tclin Maltase-glucoamylase (654 Activities)

Discover Target: MGAM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGCG Tclin Ceramide glucosyltransferase (308 Activities)

Discover Target: UGCG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLB1 Tchem Beta-galactosidase (339 Activities)

Discover Target: GLB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLA Tclin Alpha-galactosidase A (5444 Activities)

Discover Target: GLA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

Discover Target: GBA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GANAB Tchem Neutral alpha-glucosidase AB (90 Activities)

Discover Target: GANAB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GANC Tchem Neutral alpha-glucosidase C (4 Activities)

Discover Target: GANC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TREH Tchem Trehalase (5 Activities)

Discover Target: TREH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JAK1 Tclin Tyrosine-protein kinase JAK1 (8569 Activities)

Discover Target: JAK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NAGA Tbio Alpha-galactosidase B (11 Activities)

Discover Target: NAGA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1H3 Tchem LXR-alpha (2891 Activities)

Discover Target: NR1H3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MANBA Tchem Beta-mannosidase (62 Activities)

Discover Target: MANBA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FUCA1 Tchem Alpha-L-fucosidase I (304 Activities)

Discover Target: FUCA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAN2B1 Tchem Lysosomal alpha-mannosidase (172 Activities)

Discover Target: MAN2B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA2 Tchem Beta-glucosidase (258 Activities)

Discover Target: GBA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA3 Tbio Beta-glucosidase cytosolic (63 Activities)

Discover Target: GBA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SI Tchem Sucrase-isomaltase (84 Activities)

Discover Target: SI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FUT10 Tdark Fucosyltransferase 10 (23 Activities)

Discover Target: FUT10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAN2B2 Tbio Epididymis-specific alpha-mannosidase (14 Activities)

Discover Target: MAN2B2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1H2 Tchem LXR-beta (3841 Activities)

Discover Target: NR1H2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BGC-823 (3035 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MOLT-4 (49676 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MT4 (17854 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HUVEC (11049 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PBMC (10003 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGL Tbio Glycogen debranching enzyme (27 Activities)

Discover Target: AGL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LCT Tbio Lactase-phlorizin hydrolase (37 Activities)

Discover Target: LCT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCC1937 (423 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MS-1 (160 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MGAM Tclin Alpha glucosidase (860 Activities)

Discover Target: MGAM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Gusb Beta-glucuronidase (17 Activities)

Discover Target: Gusb

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

Discover Target: Ptpn1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Alpha-glucosidase (25 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lct Lactase-glycosylceramidase (87 Activities)

Discover Target: Lct

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Man2a1 Mannosidase 2 alpha 1 (15 Activities)

Discover Target: Man2a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Man2c1 Alpha-mannosidase 2C1 (19 Activities)

Discover Target: Man2c1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Man2b1 Mannosidase 2, alpha B1 (9 Activities)

Discover Target: Man2b1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gaa Acidic alpha-glucosidase (551 Activities)

Discover Target: Gaa

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

bglA Beta-glucosidase A (127 Activities)

Discover Target: bglA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

aglC Alpha-galactosidase C (14 Activities)

Discover Target: aglC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAL62 Alpha-glucosidase MAL62 (106 Activities)

Discover Target: MAL62

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

melA Alpha-galactosidase (10 Activities)

Discover Target: melA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Man1 Alpha-mannosidase (188 Activities)

Discover Target: Man1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FUCA1 Alpha-L-fucosidase 1 (358 Activities)

Discover Target: FUCA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IMA1 Oligo-1,6-glucosidase (218 Activities)

Discover Target: IMA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA1 Glucosylceramidase (58 Activities)

Discover Target: GBA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCGR Uncharacterized protein (2 Activities)

Discover Target: GCGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
INCHI	InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChi Key	LXBIFEVIBLOUGU-JGWLITMVSA-N
Canonical SMILES	C1C(C(C(C(N1)CO)O)O)O
Isomeric SMILES	C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
PubChem CID	29435
Molecular Weight	163.17

Database links

Wikipedia	1-Deoxynojirimycin
PubChem CID	29435
CAS Registry No.	19130-96-2
ChEMBL Ligand	CHEMBL307429
RCSB PDB Ligand	NOJ
Reactome Reaction	R-HSA-9686790
Reactome Drug	R-ALL-9686803

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number	Certificate Type	Date	Item
J2217436	Certificate of Analysis	Jul 17, 2024	D101242
J2217445	Certificate of Analysis	Jul 17, 2024	D101242
F2223192	Certificate of Analysis	Mar 20, 2024	D101242
J2326039	Certificate of Analysis	Oct 11, 2023	D101242
J2326040	Certificate of Analysis	Oct 11, 2023	D101242
J2326208	Certificate of Analysis	Oct 11, 2023	D101242
J2217437	Certificate of Analysis	Sep 26, 2022	D101242
B2216220	Certificate of Analysis	Jan 10, 2022	D101242
B2216221	Certificate of Analysis	Jan 10, 2022	D101242
B2216222	Certificate of Analysis	Jan 10, 2022	D101242

Chemical and Physical Properties

Solubility	Soluble in water (25 mg/ml), and methanol., Soluble in water (25 mg/ml), and methanol.
Sensitivity	Air sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Alternative Products

Citations of This Product

1. Xinlin Chen, Ying Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong. (2023) Efficient discovery of potent α-glucosidase inhibitors from Paeoniae lactiflora using enzyme–MOF nanocomposites and competitive indicators. Food & Function, 14 (1): (171-180). [PMID:36477546]
2. Yang Liu, Xue Zhou, Dan Zhou, Yongxing Jian, Jingfu Jia, Fahuan Ge. (2022) Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism. MOLECULES, 27 (18): (5742). [PMID:36144478]
3. Yanfang Yu, Yuhuan Chen, Xuping Shi, Chuan Ye, Junwen Wang, Jinzhi Huang, Bing Zhang, Zeyuan Deng. (2022) Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response. Food & Function, 13 (16): (8593-8604). [PMID:35894215]

References

1. Xinlin Chen, Ying Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong. (2023) Efficient discovery of potent α-glucosidase inhibitors from Paeoniae lactiflora using enzyme–MOF nanocomposites and competitive indicators. Food & Function, 14 (1): (171-180). [PMID:36477546]
2. Yang Liu, Xue Zhou, Dan Zhou, Yongxing Jian, Jingfu Jia, Fahuan Ge. (2022) Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism. MOLECULES, 27 (18): (5742). [PMID:36144478]
3. Yanfang Yu, Yuhuan Chen, Xuping Shi, Chuan Ye, Junwen Wang, Jinzhi Huang, Bing Zhang, Zeyuan Deng. (2022) Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response. Food & Function, 13 (16): (8593-8604). [PMID:35894215]

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1-Deoxynojirimycin - analytical standard,≥98%, high purity , CAS No.19130-96-2, Inhibitor of alpha glucosidase

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator