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1-Fluoro-2,4-dinitrobenzene - purum p.a., ≥98.0% (GC), high purity , CAS No.70-34-8

purum p.a.
≥98%(GC)

CAS#: 70-34-8
Formula: C₆H₃FN₂O₄
Molecular Weight: 186.10
MDL number: MFCD00007056
PubChem CID: 6264

Item Number

F475701

Grouped product items
SKU	Size	Availability	Price
F475701-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90
F475701-10g	10g	In stock	$47.90
F475701-25g	25g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$201.90
F475701-50g	50g	In stock	$119.90
F475701-100g	100g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$663.90
F475701-250g	250g	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$395.90

View related series

UV detection labeling reagent

Basic Description

Synonyms	2,4-Dinitrofluorobenzene\|70-34-8\|1-FLUORO-2,4-DINITROBENZENE\|Dinitrofluorobenzene\|FDNB\|DNFB\|2,4-Dinitro-1-fluorobenzene\|Sanger's Reagent\|Fluorodinitrobenzene\|2,4-Dinitrophenyl fluoride\|Fluoro-2,4-dinitrobenzene\|2,4-Dinitrobenzenefluoride\|2,4-Dinitrobenzen
Specifications & Purity	purum p.a., ≥98%(GC)
Biochemical and Physiological Mechanisms	1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity,inducing itch model,and atopic dermatitis.Mast cell activation is a key step in the DNFB induced sensitivity.DNFB covalently bin
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	purum p.a.
Product Description	1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. Thischemical is used to label the free amino groups in proteins and peptides. Itcan also be used to protect the amine group, and for phenol deoxygenation. Additionally,it is a very helpful reagent for nucleophilic substitution reactions tointroduce a chromophore group to amines, phenols, and thiols. Application： 1-Fluoro-2,4-dinitrobenzene has been used to induce severe contact hypersensitivity in mice and to monitor gene expression by in vivo imaging method,[1] and to induce chronic itch as a model for analysing itch-scratching behavior.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

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RORC Tchem Nuclear receptor ROR-gamma 0 Activities

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

Discover Target: HIF1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1H4 Tclin Bile acid receptor 0 Activities

Discover Target: NR1H4

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NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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AR Tclin Androgen receptor 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

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NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CXCL8 Tchem Interleukin-8 0 Activities

Discover Target: CXCL8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-fluoro-2,4-dinitrobenzene
INCHI	InChI=1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
InChi Key	LOTKRQAVGJMPNV-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])F
Isomeric SMILES	C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])F
PubChem CID	6264
UN Number	2811
Packing Group	I
Molecular Weight	186.10

Certificates

Certificate of Analysis(COA)

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22 results found

Lot Number	Certificate Type	Date	Item
C2421372	Certificate of Analysis	Feb 29, 2024	F475701
C2421370	Certificate of Analysis	Feb 29, 2024	F475701
C2421369	Certificate of Analysis	Feb 29, 2024	F475701
G2410056	Certificate of Analysis	Feb 29, 2024	F475701
C2421345	Certificate of Analysis	Feb 29, 2024	F475701
C2421366	Certificate of Analysis	Feb 29, 2024	F475701
C2421367	Certificate of Analysis	Feb 29, 2024	F475701
C2408427	Certificate of Analysis	Feb 21, 2024	F475701
H2423048	Certificate of Analysis	Feb 21, 2024	F475701
E2406048	Certificate of Analysis	Feb 21, 2024	F475701
C2408430	Certificate of Analysis	Feb 21, 2024	F475701
C2408429	Certificate of Analysis	Feb 21, 2024	F475701
C2408428	Certificate of Analysis	Feb 21, 2024	F475701
G2315639	Certificate of Analysis	Jul 06, 2023	F475701
G2315641	Certificate of Analysis	Jul 06, 2023	F475701
G2315642	Certificate of Analysis	Jul 06, 2023	F475701
G2315645	Certificate of Analysis	Jul 06, 2023	F475701
G2315650	Certificate of Analysis	Jul 06, 2023	F475701
G2315651	Certificate of Analysis	Jul 06, 2023	F475701
B2427587	Certificate of Analysis	Jul 06, 2023	F475701
J2331057	Certificate of Analysis	Jul 06, 2023	F475701
L2322148	Certificate of Analysis	Jul 06, 2023	F475701

Chemical and Physical Properties

Solubility	Soluble in chloroform, benzene, ether and propylene glycol.
Sensitivity	Moisture sensitive；Air sensitive
Refractive Index	1.569 (lit.)
Flash Point(°C)	>110°C
Boil Point(°C)	296°C
Melt Point(°C)	24-30°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H311:Toxic in contact with skin H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H318:Causes serious eye damage H317:May cause an allergic skin reaction H330:Fatal if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
Class	6.1

References

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