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1-Lauroyl-rac-glycerol - ≥99%, high purity , CAS No.142-18-7

2 Citations

≥99%

CAS#: 142-18-7
Formula: C₁₅H₃₀O₄
Molecular Weight: 274.4
Beilstein Registry Number: 1726740
MDL number: MFCD00037815
PubChem CID: 14871

Item Number

L465534

Grouped product items
SKU	Size	Availability	Price
L465534-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$162.90
L465534-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$444.90
L465534-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$553.90
L465534-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,724.90

Basic Description

Synonyms	Monolaurin \| 2,3-Dihydroxypropyl dodecanoate \| 142-18-7 \| 1-Monolaurin \| Glyceryl monolaurate \| Lauricidin \| GLYCERYL LAURATE \| 1-Glyceryl laurate \| Glycerol 1-laurate \| 27215-38-9 \| 1-Monolauroyl-rac-glycerol \| 1-Monododecanoylglycerol \| Glycerol monolaurate \| Laurin, 1-mono- \| Gly
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Monolaurin (1-Lauroyl-rac-glycerol) is used as an antimicrobial agent in various formulas and microemulsions and as a methane mitigation agent in ruminants.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)

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ABCB1 Tchem Multidrug resistance protein 1 (0 Activities)

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HDAC6 Tclin Histone deacetylase 6 (0 Activities)

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LMNA Tbio Prelamin-A/C (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Homo sapiens (32628 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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MIA PaCa-2 (5949 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCT-116 (91556 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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MDA-N (28205 Activities)

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MDA-MB-231 (73002 Activities)

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SNB-75 (44215 Activities)

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NCI-H226 (44470 Activities)

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NCI-H23 (49055 Activities)

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Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Haemophilus (24 Activities)

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Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus (1598 Activities)

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Gardnerella vaginalis (35 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lacticaseibacillus casei (578 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pichia kudriavzevii (7448 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Kluyveromyces marxianus (909 Activities)

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Candida (1648 Activities)

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Candida albicans (78123 Activities)

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Nakaseomyces glabratus (9108 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida parapsilosis (8521 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida tropicalis (8381 Activities)

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Artemia (698 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Human immunodeficiency virus (3636 Activities)

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Rhesus monkey (3147 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	2,3-dihydroxypropyl dodecanoate
INCHI	InChI=1S/C15H30O4/c1-2-3-4-5-6-7-8-9-10-11-15(18)19-13-14(17)12-16/h14,16-17H,2-13H2,1H3
InChi Key	ARIWANIATODDMH-UHFFFAOYSA-N
Canonical SMILES	CCCCCCCCCCCC(=O)OCC(CO)O
Isomeric SMILES	CCCCCCCCCCCC(=O)OCC(CO)O
WGK Germany	1
RTECS	OF1600000
Alternate CAS	27215-38-9
PubChem CID	14871
Molecular Weight	274.4
Beilstein	1726740
Reaxy-Rn	1726740

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Boil Point(°C)	186°C/1mmHg(lit.)
Melt Point(°C)	63 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	1
RTECS	OF1600000
Reaxy-Rn	1726740

Citations of This Product

1. Jiawei Li, Linhe Zhao, Chengyu Hong, Mengsong Liu, Yongquan Wang, Yutong Song, Ruixue Zhai, Jiaqi Zhang, Chao Zhou. (2024) Synthesis and characterization of waterborne polyurethane-based ink binder modified via a silane coupling agent. PROGRESS IN ORGANIC COATINGS, 186 (108018). [PMID:31548606]
2. Shunjing Luo, Shaobai Xiong, Xianbao Li, Xiuting Hu, Jiangping Ye, Chengmei Liu. (2022) Impact of starch–lipid complexes on oil absorption of starch and its mechanism. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (1): (83-91). [PMID:35792714]

References

1. H Shimada,V E Tyler,J L McLaughlin. (1997-04-01) Biologically active acylglycerides from the berries of saw-palmetto (Serenoa repens).. Journal of natural products, 60 ((4)): (417-418). [PMID:9134750]
2. Patrick M Schlievert,Kristi L Strandberg,Amanda J Brosnahan,Marnie L Peterson,Stefan E Pambuccian,Karla R Nephew,Kevin G Brunner,Nancy J Schultz-Darken,Ashley T Haase. (2008-10-08) Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic use.. Antimicrobial agents and chemotherapy, 52 ((12)): (4448-4454). [PMID:18838587]
3. Peter J McNamara,Rae Ellen Syverson,Kathy Milligan-Myhre,Olga Frolova,Sarah Schroeder,Joshua Kidder,Thanh Hoang,Richard A Proctor. (2009-02-19) Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.. Antimicrobial agents and chemotherapy, 53 ((5)): (1898-1906). [PMID:19223628]
4. Fenja Klevenhusen,Stefano M Bernasconi,Thomas B Hofstetter,Jakov Bolotin,Carmen Kunz,Carla R Soliva. (2009-06-10) Efficiency of monolaurin in mitigating ruminal methanogenesis and modifying C-isotope fractionation when incubating diets composed of either C3 or C4 plants in a rumen simulation technique (Rusitec) system.. The British journal of nutrition, 102 ((9)): (1308-1317). [PMID:19505345]
5. M A Al-Holy,L F Castro,H M Al-Qadiri. (2009-12-23) Inactivation of Cronobacter spp. (Enterobacter sakazakii) in infant formula using lactic acid, copper sulfate and monolaurin.. Letters in applied microbiology, 50 ((3)): (246-251). [PMID:20025649]
6. Hui Zhang,Yinan Cui,Songming Zhu,Fengqin Feng,Xiaodong Zheng. (2010-06-29) Characterization and antimicrobial activity of a pharmaceutical microemulsion.. International journal of pharmaceutics, 395 ((1-2)): (154-160). [PMID:20580790]
7. Ângela S Inácio,Katia A Mesquita,Marta Baptista,João Ramalho-Santos,Winchil L C Vaz,Otília V Vieira. (2011-05-24) In vitro surfactant structure-toxicity relationships: implications for surfactant use in sexually transmitted infection prophylaxis and contraception.. PloS one, 6 ((5)): (e19850-e19850). [PMID:21603626]
8. Ketan Patel,Vidur Sarma,Pradeep Vavia. (2013-03-28) Design and evaluation of Lumefantrine - Oleic acid self nanoemulsifying ionic complex for enhanced dissolution.. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 21 ((1)): (27-27). [PMID:23531442]
9. Sara Raposo,Rita Tavares,Lídia Gonçalves,Sandra Simões,Manuela Urbano,Helena M Ribeiro. (2014-02-25) Mometasone furoate-loaded cold processed oil-in-water emulsions: in vitro and in vivo studies.. Drug delivery, 22 ((4)): (562-572). [PMID:24559480]
10. Youngseok Ham, Tae-Jong Kim,. (2016-09-22) Inhibitory activity of monoacylglycerols on biofilm formation in Aeromonas hydrophila, Streptococcus mutans, Xanthomonas oryzae, and Yersinia enterocolitica.. SpringerPlus, 5 ((1)): ( 1526-1526 ). [PMID:27652099]
11. Lauren C Radlinski,Sarah E Rowe,Robert Brzozowski,Alec D Wilkinson,Rennica Huang,Prahathees Eswara,Brian P Conlon. (2019-08-14) Chemical Induction of Aminoglycoside Uptake Overcomes Antibiotic Tolerance and Resistance in Staphylococcus aureus.. Cell chemical biology, 26 ((10)): (1355-1364). [PMID:31402316]
12. Ping-Yi Li, Yan-Qi Zhang, Yi Zhang, Wen-Xin Jiang, Yan-Jun Wang, Yi-Shuo Zhang, Zhong-Zhi Sun, Chun-Yang Li, Yu-Zhong Zhang, Mei Shi, Xiao-Yan Song, Long-Sheng Zhao, Xiu-Lan Chen,. (2020-02-11) Study on a Novel Cold-Active and Halotolerant Monoacylglycerol Lipase Widespread in Marine Bacteria Reveals a New Group of Bacterial Monoacylglycerol Lipases Containing Unusual C(A/S)HSMG Catalytic Motifs.. Frontiers in microbiology, ( 9-9 ). [PMID:32038595]
13. Amlan K Patra,Jyotisna Saxena. (2010-06-24) A new perspective on the use of plant secondary metabolites to inhibit methanogenesis in the rumen.. Phytochemistry, 71 ((11-12)): (1198-1222). [PMID:20570294]
14. Stewart Bachan,Jacques Fantini,Anjali Joshi,Himanshu Garg,David R Mootoo. (2011-07-26) Synthesis, gp120 binding and anti-HIV activity of fatty acid esters of 1,1-linked disaccharides.. Bioorganic & medicinal chemistry, 19 ((16)): (4803-4811). [PMID:21783371]
15. Fenja Klevenhusen,Leo Meile,Michael Kreuzer,Carla R Soliva. (2011-07-27) Effects of monolaurin on ruminal methanogens and selected bacterial species from cattle, as determined with the rumen simulation technique.. Anaerobe, 17 ((5)): (232-238). [PMID:21787874]
16. Luis Vázquez,Noemí González,Guillermo Reglero,Carlos Torres. (2016-02-24) Solvent-Free Lipase-Catalyzed Synthesis of Diacylgycerols as Low-Calorie Food Ingredients.. Frontiers in bioengineering and biotechnology, 4 (6-6). [PMID:26904539]
17. Jiawei Li, Linhe Zhao, Chengyu Hong, Mengsong Liu, Yongquan Wang, Yutong Song, Ruixue Zhai, Jiaqi Zhang, Chao Zhou. (2024) Synthesis and characterization of waterborne polyurethane-based ink binder modified via a silane coupling agent. PROGRESS IN ORGANIC COATINGS, 186 (108018). [PMID:31548606]
18. Shunjing Luo, Shaobai Xiong, Xianbao Li, Xiuting Hu, Jiangping Ye, Chengmei Liu. (2022) Impact of starch–lipid complexes on oil absorption of starch and its mechanism. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (1): (83-91). [PMID:35792714]

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