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M338296-25mg

25mg

Available within 8-12 weeks(?)

$332.90

Basic Description

Synonyms	AMY23633 \| AKOS003657026 \| N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine \| 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine \| BRN 0133712 \| J-017031 \| CHEBI:17963 \| PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-PHENYL- \| 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine \| E
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	A dopaminergic neurotoxin which reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Associated Targets(Human)

QDPR Tchem Dihydropteridine reductase (0 Activities)

Discover Target: QDPR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC22A3 Tchem Solute carrier family 22 member 3 (0 Activities)

Discover Target: SLC22A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC29A4 Tchem Equilibrative nucleoside transporter 4 (0 Activities)

Discover Target: SLC29A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC22A5 Tbio Solute carrier family 22 member 5 (0 Activities)

Discover Target: SLC22A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter (0 Activities)

Discover Target: SLC6A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD5 Tchem D(1B) dopamine receptor (0 Activities)

Discover Target: DRD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B (0 Activities)

Discover Target: MAOB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A (0 Activities)

Discover Target: MAOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOS2 Tchem Nitric oxide synthase, inducible (0 Activities)

Discover Target: NOS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOS1 Tchem Nitric oxide synthase, brain (0 Activities)

Discover Target: NOS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)

Discover Target: NOS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC29A4 Tchem Equilibrative nucleoside transporter 4 (23 Activities)

Discover Target: SLC29A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Nos2 Nitric oxide synthase, inducible (3573 Activities)

Discover Target: Nos2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Qdpr Dihydropteridine reductase (31 Activities)

Discover Target: Qdpr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc22a5 Solute carrier family 22 member 5 (44 Activities)

Discover Target: Slc22a5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc22a3 Solute carrier family 22 member 3 (35 Activities)

Discover Target: Slc22a3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Drd5 Dopamine receptor (1304 Activities)

Discover Target: Drd5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Maob Monoamine oxidase (439 Activities)

Discover Target: Maob

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-methyl-4-phenyl-3,6-dihydro-2H-pyridine
INCHI	InChI=1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
InChi Key	PLRACCBDVIHHLZ-UHFFFAOYSA-N
Canonical SMILES	CN1CCC(=CC1)C2=CC=CC=C2
Isomeric SMILES	CN1CCC(=CC1)C2=CC=CC=C2
PubChem CID	1388
Molecular Weight	173.26

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Soluble in Chloroform, Dichloromethane and Ethyl Acetate
Boil Point(°C)	128-132° C (lit.) at 12 mmHg
Melt Point(°C)	37-40° C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H370:Causes damage to organs
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P308+P316:IF exposed or concerned: Get emergency medical help immediately.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841]
2. Zhang Mao, Haochen Hui, Xuerong Zhao, Lina Xu, Yan Qi, Lianhong Yin, Liping Qu, Lan Han, Jinyong Peng. (2023) Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling. Journal of Pharmaceutical Analysis, [PMID:38024855]
3. Qiang-Ming Li, Xiang Li, Shuang-Qiao Su, Yu-Tong Wang, Tong Xu, Xue-Qiang Zha, Li-Hua Pan, Zhen-Zi Shang, Feng-Yun Zhang, Jian-Ping Luo. (2022) Dendrobine inhibits dopaminergic neuron apoptosis via MANF-mediated ER stress suppression in MPTP/MPP+-induced Parkinson's disease models. PHYTOMEDICINE, 102 (154193). [PMID:35636177]
4. Wang Wang, Guoxue Zhu, Yuwen Wang, Wei Li, Shilin Yi, Kai Wang, Lu Fan, Juanjuan Tang, Ruini Chen. (2022) Multi-Omics Integration in Mice With Parkinson’s Disease and the Intervention Effect of Cyanidin-3-O-Glucoside. Frontiers in Aging Neuroscience, 14 (877078). [PMID:35572129]
5. Tingting Wu, Xianying Fang, Jiahui Xu, Yan Jiang, Fuliang Cao, Linguo Zhao. (2020) Synergistic Effects of Ginkgolide B and Protocatechuic Acid on the Treatment of Parkinson’s Disease. MOLECULES, 25 (17): (3976). [PMID:32878312]

References

1. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841]
2. Zhang Mao, Haochen Hui, Xuerong Zhao, Lina Xu, Yan Qi, Lianhong Yin, Liping Qu, Lan Han, Jinyong Peng. (2023) Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling. Journal of Pharmaceutical Analysis, [PMID:38024855]
3. Qiang-Ming Li, Xiang Li, Shuang-Qiao Su, Yu-Tong Wang, Tong Xu, Xue-Qiang Zha, Li-Hua Pan, Zhen-Zi Shang, Feng-Yun Zhang, Jian-Ping Luo. (2022) Dendrobine inhibits dopaminergic neuron apoptosis via MANF-mediated ER stress suppression in MPTP/MPP+-induced Parkinson's disease models. PHYTOMEDICINE, 102 (154193). [PMID:35636177]
4. Wang Wang, Guoxue Zhu, Yuwen Wang, Wei Li, Shilin Yi, Kai Wang, Lu Fan, Juanjuan Tang, Ruini Chen. (2022) Multi-Omics Integration in Mice With Parkinson’s Disease and the Intervention Effect of Cyanidin-3-O-Glucoside. Frontiers in Aging Neuroscience, 14 (877078). [PMID:35572129]
5. Tingting Wu, Xianying Fang, Jiahui Xu, Yan Jiang, Fuliang Cao, Linguo Zhao. (2020) Synergistic Effects of Ginkgolide B and Protocatechuic Acid on the Treatment of Parkinson’s Disease. MOLECULES, 25 (17): (3976). [PMID:32878312]

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base - 98%, high purity , CAS No.28289-54-5