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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride - ≥98%, high purity , CAS No.23007-85-4

2 Citations
Item Number
M132847
Grouped product items
SKUSizeAvailabilityPrice Qty
M132847-25mg
25mg
In stock
$78.90
M132847-100mg
100mg
In stock
$228.90
M132847-500mg
500mg
In stock
$801.90
M132847-1g
1g
In stock
$1,283.90
M132847-5g
5g
In stock
$9,513.90
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Apoptosis Dopamine Receptor GPCR/G Protein Neuronal Signaling Pyridines

Basic Description

SynonymsMPTP Hydrochloride
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological Mechanisms1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo a
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is a dopaminergic neurotoxin experimentally exhibiting severe and irreversible Parkinsonian conditions.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHAT Tchem Choline acetylase (63 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488188334
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488188334
IUPAC Name 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine;hydrochloride
INCHI InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChi Key KOWJANGMTAZWDT-UHFFFAOYSA-N
Canonical SMILES CN1CCC(=CC1)C2=CC=CC=C2.Cl
Isomeric SMILES CN1CCC(=CC1)C2=CC=CC=C2.Cl
WGK Germany 3
RTECS UT8358950
PubChem CID 161406
Molecular Weight 209.715
Beilstein 3707310
Reaxy-Rn 3707312

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

33 results found

Lot NumberCertificate TypeDateItem
K2427519Certificate of AnalysisNov 12, 2024 M132847
K2427518Certificate of AnalysisNov 12, 2024 M132847
K2427517Certificate of AnalysisNov 12, 2024 M132847
K2427516Certificate of AnalysisNov 12, 2024 M132847
K2427515Certificate of AnalysisNov 12, 2024 M132847
K2225585Certificate of AnalysisSep 14, 2024 M132847
K2225584Certificate of AnalysisSep 14, 2024 M132847
E2423550Certificate of AnalysisMay 13, 2024 M132847
E2423551Certificate of AnalysisMay 13, 2024 M132847
E2423552Certificate of AnalysisMay 13, 2024 M132847
E2423553Certificate of AnalysisMay 13, 2024 M132847
H2314467Certificate of AnalysisAug 03, 2023 M132847
L2301103Certificate of AnalysisAug 03, 2023 M132847
H2314469Certificate of AnalysisAug 03, 2023 M132847
H2314468Certificate of AnalysisAug 03, 2023 M132847
H2314466Certificate of AnalysisAug 03, 2023 M132847
H2314465Certificate of AnalysisAug 03, 2023 M132847
E23261073Certificate of AnalysisMay 05, 2023 M132847
E23261083Certificate of AnalysisMay 05, 2023 M132847
E23261091Certificate of AnalysisMay 05, 2023 M132847
E23261097Certificate of AnalysisMay 05, 2023 M132847
E2326786Certificate of AnalysisMay 05, 2023 M132847
E2326789Certificate of AnalysisMay 05, 2023 M132847
E2326790Certificate of AnalysisMay 05, 2023 M132847
E2326791Certificate of AnalysisMay 05, 2023 M132847
E2326792Certificate of AnalysisMay 05, 2023 M132847
E2327339Certificate of AnalysisMay 05, 2023 M132847
K2225583Certificate of AnalysisNov 08, 2022 M132847
K2225575Certificate of AnalysisNov 08, 2022 M132847
J2210590Certificate of AnalysisJul 20, 2022 M132847
J2210585Certificate of AnalysisJul 20, 2022 M132847
J2210584Certificate of AnalysisJul 20, 2022 M132847
J2210583Certificate of AnalysisJul 20, 2022 M132847

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Chemical and Physical Properties

SolubilitySoluble in DMSO and Water.
SensitivityHeat sensitive & Hygroscopic
Melt Point(°C)249.0 - 254.0 °C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H301:Toxic if swallowed

H311:Toxic in contact with skin

H331:Toxic if inhaled

H301+H311+H331:Toxic if swallowed, in contact with skin or if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P361+P364:Take off immediately all contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P316:Get emergency medical help immediately.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS UT8358950
Reaxy-Rn 3707312

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. MPTP hydrochloride - 10mM in DMSO, used for , CAS No. 23007-85-4(DMSO), by Aladdin Scientific
    MPTP hydrochloride
    • 10mM in DMSO

    Starting at $99.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang.  (2019)  Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease.  Aging-US,  11  (21): ( 9424–9441).  [PMID:31697645] [10.18632/aging.102394]
2. Shuang Li, Jiaxin Liu, Ge Li, Xueyan Zhang, Fei Xu, Zhijiang Fu, Lesheng Teng, Youxin Li, Fengying Sun.  (2019)  Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,  141  (1).  [PMID:31100429] [10.1016/j.ejpb.2019.05.013]

References

1. Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang.  (2019)  Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease.  Aging-US,  11  (21): ( 9424–9441).  [PMID:31697645] [10.18632/aging.102394]
2. Shuang Li, Jiaxin Liu, Ge Li, Xueyan Zhang, Fei Xu, Zhijiang Fu, Lesheng Teng, Youxin Li, Fengying Sun.  (2019)  Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,  141  (1).  [PMID:31100429] [10.1016/j.ejpb.2019.05.013]

Solution Calculators

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