1-Methyl-L-tryptophan - ≥95%, high purity , CAS No.21339-55-9, Inhibitor of indoleamine 2;3-dioxygenase 1

Item Number
M138479
Grouped product items
SKUSizeAvailabilityPrice Qty
M138479-250mg
250mg
In stock
$11.90
M138479-1g
1g
In stock
$36.90
M138479-5g
5g
In stock
$133.90
M138479-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$602.90

Basic Description

SynonymsEN300-7398929 | (S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid | BDBM50241727 | 1-LMT | 1-L-MT | A51061 | H-Trp(1-Me)-OH | TRYPTOPHAN, 1-METHYL-, L | XD0FY1J13B | Q-100266 | A815282 | EXL | (2S)-2-amino-3-(1-methyl-3-indolyl)propanoic acid | 1-Methy
Specifications & PurityMoligand™, ≥95%
Shipped InNormal
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of indoleamine 2;3-dioxygenase 1

Associated Targets(Human)

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DHFR Tclin Dihydrofolate reductase (3072 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-375 (9258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Tdo2 Tryptophan 2,3-dioxygenase (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lewis lung carcinoma cell line (1243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H22 (575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16-F10 (4610 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ido1 Indoleamine 2,3-dioxygenase 1 (313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid
INCHI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1
InChi Key ZADWXFSZEAPBJS-JTQLQIEISA-N
Canonical SMILES CN1C=C(C2=CC=CC=C21)CC(C(=O)O)N
Isomeric SMILES CN1C=C(C2=CC=CC=C21)C[C@@H](C(=O)O)N
WGK Germany 3
PubChem CID 676159
Molecular Weight 218.25

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
D2218036Certificate of AnalysisFeb 22, 2024 M138479
D2218040Certificate of AnalysisFeb 22, 2024 M138479
D2218041Certificate of AnalysisFeb 22, 2024 M138479
D2218046Certificate of AnalysisFeb 22, 2024 M138479
H2311023Certificate of AnalysisMar 11, 2022 M138479
J1526086Certificate of AnalysisFeb 16, 2022 M138479

Chemical and Physical Properties

Specific Rotation[α][α]24/D −8.0°, c = 2 in acetic acid
Melt Point(°C)242-245 °C (lit.)

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

Citations of This Product

1. Ning Wang, Jie Zhang, Qiao Li, Hui Xu, Geng Chen, Zhiyong Li, Difa Liu, Xin Yang.  (2019)  Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation.  FITOTERAPIA,  133  (137).  [PMID:30654128] [10.1016/j.fitote.2019.01.005]

References

1. Vottero E, Balgi A, Woods K, Tugendreich S, Melese T, Andersen RJ, Mauk AG, Roberge M.  (2006)  Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast..  Biotechnol J,  (3): (282-8).  [PMID:16897708] [10.1021/op500134e]
2. Yang S, Li X, Hu F, Li Y, Yang Y, Yan J, Kuang C, Yang Q.  (2013)  Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice..  J Med Chem,  56  (21): (8321-31).  [PMID:24099220] [10.1021/op500134e]
3. Ning Wang, Jie Zhang, Qiao Li, Hui Xu, Geng Chen, Zhiyong Li, Difa Liu, Xin Yang.  (2019)  Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation.  FITOTERAPIA,  133  (137).  [PMID:30654128] [10.1016/j.fitote.2019.01.005]

Solution Calculators