Grouped product items

SKU

Size

Availability

Price

Qty

N159793-1ml

1ml

Available within 4-8 weeks(?)

$9.90

N159793-5ml

5ml

Available within 8-12 weeks(?)

$12.90

N159793-25ml

25ml

Available within 4-8 weeks(?)

$28.90

N159793-100ml

100ml

Available within 4-8 weeks(?)

$79.90

Basic Description

Synonyms	(R)-ALPHA-CYANOBENZYLACETATE \| NSC 4023 \| 1-Naphthyl isocyanate, 98% \| Naphthalene, isocyanato- \| FT-0651962 \| UNII-5LH2P0691E \| W-104056 \| AB00331 \| NAPHTHYL ISOCYANATE, 1- \| NSC-4023 \| naphthyl isocyanate \| naphthylisocyanat \| 1-Naphthyl isocyanate \| 1-
Specifications & Purity	≥99.0%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice

Associated Targets(Human)

ABCB1 Tchem Multidrug resistance protein 1 (0 Activities)

Discover Target: ABCB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (0 Activities)

Discover Target: ABCC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC6 Tbio Multidrug resistance-associated protein 6 (0 Activities)

Discover Target: ABCC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC10A1 Tclin Sodium/bile acid cotransporter (0 Activities)

Discover Target: SLC10A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)

Discover Target: ABCC3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc10a1 Bile acid transporter (65 Activities)

Discover Target: Slc10a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mdr1a Multidrug resistance protein 1a (106 Activities)

Discover Target: Mdr1a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)

Discover Target: Slco1a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-isocyanatonaphthalene
INCHI	InChI=1S/C11H7NO/c13-8-12-11-7-3-5-9-4-1-2-6-10(9)11/h1-7H
InChi Key	BDQNKCYCTYYMAA-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C=CC=C2N=C=O
Isomeric SMILES	C1=CC=C2C(=C1)C=CC=C2N=C=O
WGK Germany	3
PubChem CID	66589
Molecular Weight	169.18
Beilstein	742779
Reaxy-Rn	742779

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
D2428419	Certificate of Analysis	May 11, 2024	N159793
D2428420	Certificate of Analysis	May 11, 2024	N159793
D2428421	Certificate of Analysis	May 11, 2024	N159793
D2428422	Certificate of Analysis	May 11, 2024	N159793
D2428423	Certificate of Analysis	May 11, 2024	N159793
L1911075	Certificate of Analysis	Sep 11, 2023	N159793
B2212039	Certificate of Analysis	Feb 19, 2022	N159793

Chemical and Physical Properties

Solubility	Miscible with alcohol, chloroform and diethyl ether.
Sensitivity	light &heat & Moisture sensitive
Refractive Index	1.63
Flash Point(°F)	235.4 °F
Flash Point(°C)	135°C(lit.)
Boil Point(°C)	269°C(lit.)
Melt Point(°C)	4 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H318:Causes serious eye damage H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3
Reaxy-Rn	742779
Merck Index	6410

References

1. T Ullrich,S Menge,M Schmid,G Gübitz,G J Krauss. (2001-06-08) Enantioselective high-performance liquid chromatography of therapeutically relevant aminoalcohols as their fluorescent 1-naphthyl isocyanate derivatives.. Biomedical chromatography : BMC, 15 ((3)): (212-216). [PMID:11391679]
2. Ming-Ling Chang,Chau-Ting Yeh,Pei-Yeh Chang,Jeng-Chang Chen. (2005-07-15) Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation.. World journal of gastroenterology, 11 ((27)): (4167-4172). [PMID:16015684]
3. Ying Zhao,Desheng Zhai,Xijing Chen,Jinnan Yang,Xiangfeng Song,Hui He,Qiaoling Yu,Yan Xing. (2006-12-23) Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats.. Toxicology, 230 ((2-3)): (145-150). [PMID:17184895]
4. Desheng Zhai,Ying Zhao,Xijing Chen,Jiqiang Guo,Hui He,Qiaoling Yu,Jinnan Yang,Andrew K Davey,Jiping Wang. (2007-01-09) Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats.. Planta medica, 73 ((2)): (128-133). [PMID:17206559]
5. Christopher J McEntyre,Sandy Slow,Michael Lever. (2009-05-26) Measurement of plasma free choline by high performance liquid chromatography with fluorescence detection following derivatization with 1-naphthyl isocyanate.. Analytica chimica acta, 644 ((1-2)): (90-94). [PMID:19463568]
6. Q Yang,Z P Sun,D K Ling. (1989-01-01) [Application of Pirkle-type chiral column to the resolution of enantiomeric drugs: resolution and identification of alpha-naphthyl isocyanate derivatives of alprenolol and some other beta-blockers].. Yao xue xue bao = Acta pharmaceutica Sinica, 24 ((4)): (285-289). [PMID:2573231]
7. Yaping Liu,Jane Binz,Mary Jo Numerick,Steve Dennis,Guizhen Luo,Bhasha Desai,Kathleen I MacKenzie,Traci A Mansfield,Steven A Kliewer,Bryan Goodwin,Stacey A Jones. (2003-11-19) Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.. The Journal of clinical investigation, 112 ((11)): (1678-1687). [PMID:14623915]
8. Shashi K Ramaiah,Hartmut Jaeschke. (2007-10-19) Role of neutrophils in the pathogenesis of acute inflammatory liver injury.. Toxicologic pathology, 35 ((6)): (757-766). [PMID:17943649]

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1-Naphthyl Isocyanate - ≥99.0%, high purity , CAS No.86-84-0

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
N159793-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$9.90
N159793-5ml	5ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$12.90
N159793-25ml	25ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$28.90
N159793-100ml	100ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$79.90