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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P160275-1g | 1g | In stock | $54.90 | |
P160275-5g | 5g | In stock | $209.90 | |
P160275-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $376.90 | |
P160275-25g | 25g | In stock | $846.90 | |
P160275-100g | 100g | In stock | $3,047.90 |
Synonyms | 12N-710 | 1-Phenyl-1H-imidazole | CS-W004969 | 1-Phenylimidazole | N-Phenylimidazole | AKOS006223210 | P2030 | (Trimethylsilyl)phenylacetylene | AMY11870 | Z440825046 | Maybridge1_002053 | J-505057 | MFCD01529867 | EN300-67324 | Phenylimidazole | FT-06082 |
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Specifications & Purity | ≥97%(GC) |
Storage Temp | Argon charged |
Shipped In | Normal |
Product Description | 1-Phenylimidazole is an imidazole derivative. It induces 7-ethoxyresorufin-O-deethylase (EROD) activity in rainbow trout (Oncorhynchus mykiss) hepatocytes.The S(1)→S(0) transition of 1-phenylimidazole has been investigated in a supersonic jet expansion by resonant two-photon ionization.1-Phenylimidazole is reported to be inhibitor of calmodulin-dependent nitric-oxide synthase from bovine brain and GHs pituitary cells application: 1-Phenylimidazole is a suitable reagent used to investigate its effect on the citrulline formation by bovine brain nitric-oxide synthase. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488185984 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488185984 |
IUPAC Name | 1-phenylimidazole |
INCHI | InChI=1S/C9H8N2/c1-2-4-9(5-3-1)11-7-6-10-8-11/h1-8H |
InChi Key | SEULWJSKCVACTH-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)N2C=CN=C2 |
Isomeric SMILES | C1=CC=C(C=C1)N2C=CN=C2 |
WGK Germany | 3 |
PubChem CID | 81595 |
Molecular Weight | 144.18 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2215224 | Certificate of Analysis | Jun 14, 2022 | P160275 |
H2215225 | Certificate of Analysis | Jun 14, 2022 | P160275 |
H2215226 | Certificate of Analysis | Jun 14, 2022 | P160275 |
H2215227 | Certificate of Analysis | Jun 14, 2022 | P160275 |
C2224043 | Certificate of Analysis | Nov 20, 2021 | P160275 |
E2331133 | Certificate of Analysis | Nov 20, 2021 | P160275 |
F2205298 | Certificate of Analysis | Nov 20, 2021 | P160275 |
F2222472 | Certificate of Analysis | Nov 20, 2021 | P160275 |
Solubility | Slightly soluble in water. |
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Sensitivity | Air sensitive |
Refractive Index | 1.6 |
Flash Point(°F) | 235.4 °F |
Flash Point(°C) | 113 °C |
Boil Point(°C) | 142°C/15mmHg(lit.) |
Melt Point(°C) | 13°C(lit.) |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
1. J A Zijlstra,E W Vogel. (1988-11-01) Influence of inhibition of the metabolic activation on the mutagenicity of some nitrosamines, triazenes, hydrazines and seniciphylline in Drosophila melanogaster.. Mutation research, 202 ((1)): (251-267). [PMID:3141806] |
2. M Murray,C F Wilkinson,K Hetnarski. (1985-05-01) Cytochrome P-450 and monooxygenase activity in hepatic microsomes from N-phenylimidazole-treated rats.. Toxicology letters, 25 ((2)): (191-198). [PMID:3873725] |
3. L R Kao,C F Wilkinson. (1987-07-01) Inhibition of cytochrome P-450c-mediated benzo[a]pyrene hydroxylase and ethoxyresorufin O-deethylase by dihydrosafrole.. Xenobiotica; the fate of foreign compounds in biological systems, 17 ((7)): (793-805). [PMID:3660849] |
4. C F Wilkinson,K Hetnarski,M S Denison,F P Guengerich. (1983-03-15) Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation.. Biochemical pharmacology, 32 ((6)): (997-1003). [PMID:6838663] |
5. D J Wolff,G A Datto,R A Samatovicz,R A Tempsick. (1993-05-05) Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imidazole and phenylimidazoles.. The Journal of biological chemistry, 268 ((13)): (9425-9429). [PMID:7683651] |
6. P Ammann,C L Laethem,G L Kedderis. (1998-05-08) Chloroform-induced cytolethality in freshly isolated male B6C3F1 mouse and F-344 rat hepatocytes.. Toxicology and applied pharmacology, 149 ((2)): (217-225). [PMID:9571991] |
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8. A Hirashima,C Pan,E Kuwano,E Taniguchi,M Eto. (1999-08-28) Three-dimensional pharmacophore hypotheses for the locust neuronal octopamine receptor (OAR3). Part 2: agonists.. Bioorganic & medicinal chemistry, 7 ((7)): (1437-1443). [PMID:10465417] |
9. S C Vashishtha,E M Hawes,G McKay,D J McCann. (2000-08-19) Synthesis and identification of the quaternary ammonium-linked glucuronide of 1-phenylimidazole in human liver microsomes and investigation of the human UDP-glucuronosyltransferases involved.. Drug metabolism and disposition: the biological fate of chemicals, 28 ((9)): (1009-1013). [PMID:10950841] |
10. A J Green,S L Rivers,M Cheeseman,G A Reid,L G Quaroni,I D Macdonald,S K Chapman,A W Munro. (2001-07-27) Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis.. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 6 ((5-6)): (523-533). [PMID:11472016] |
11. Evan G Robertson,Christopher D Thompson,Richard J S Morrison. (2004-12-21) Interplanar torsion in the S1<--S0 electronic spectrum of jet cooled 1-phenylimidazole.. The Journal of chemical physics, 121 ((24)): (12421-12427). [PMID:15606262] |
12. Filippo Monti,Maria Grazia I La Placa,Nicola Armaroli,Rosario Scopelliti,Michael Grätzel,Mohammad Khaja Nazeeruddin,Florian Kessler. (2015-03-06) Cationic iridium(III) complexes with two carbene-based cyclometalating ligands: cis versus trans isomers.. Inorganic chemistry, 54 ((6)): (3031-3042). [PMID:25741900] |
13. Mehdi Rajabnia Khansari,Bahareh Sadat Yousefsani,Farzad Kobarfard,Mehrdad Faizi,Jalal Pourahmad. (2017-08-27) In vitro toxicity of perfluorooctane sulfonate on rat liver hepatocytes: probability of distructive binding to CYP 2E1 and involvement of cellular proteolysis.. Environmental science and pollution research international, 24 ((29)): (23382-23388). [PMID:28842823] |
14. Priyadarshini Balaraman,Erika Plettner. (2018-11-06) Chemotaxis by Pseudomonas putida (ATCC 17453) towards camphor involves cytochrome P450cam (CYP101A1).. Biochimica et biophysica acta. General subjects, 1863 ((2)): (304-312). [PMID:30391161] |
15. J A Zijlstra,E W Vogel. (1988-03-01) Metabolic inactivation of mutagens in Drosophila melanogaster.. Mutation research, 198 ((1)): (73-83). [PMID:3127701] |
16. P R Kerklaan,S Bouter,J A Zijlstra,G R Mohn. (1986-01-01) The effect of mixed-function oxidase and amine oxidase inhibitors on the activation of dialkylnitrosamines and 1,2-dimethylhydrazine to bacterial mutagens in mice.. Journal of cancer research and clinical oncology, 111 ((3)): (196-202). [PMID:3525573] |
17. D M Grant,M E Campbell,B K Tang,W Kalow. (1987-04-15) Biotransformation of caffeine by microsomes from human liver. Kinetics and inhibition studies.. Biochemical pharmacology, 36 ((8)): (1251-1260). [PMID:3593412] |
18. D J Wolff,B J Gribin. (1994-06-01) Interferon-gamma-inducible murine macrophage nitric oxide synthase: studies on the mechanism of inhibition by imidazole agents.. Archives of biochemistry and biophysics, 311 ((2)): (293-299). [PMID:7515612] |
19. D J Wolff,B J Gribin. (1994-06-01) The inhibition of the constitutive and inducible nitric oxide synthase isoforms by indazole agents.. Archives of biochemistry and biophysics, 311 ((2)): (300-306). [PMID:7515613] |
20. D J Wolff,A Lubeskie,S Umansky. (1994-11-01) The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agents.. Archives of biochemistry and biophysics, 314 ((2)): (360-366). [PMID:7526799] |
21. R M Chabin,E McCauley,J R Calaycay,T M Kelly,K L MacNaul,G C Wolfe,N I Hutchinson,S Madhusudanaraju,J A Schmidt,J W Kozarich,K K Wong. (1996-07-23) Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.. Biochemistry, 35 ((29)): (9567-9575). [PMID:8755738] |
22. A Jos,H Segner,B Herradón,G Repetto,J M Navas. (2007-05-25) Induction of EROD activity by 1-phenylimidazole and beta-naphthoflavone in rainbow trout cultured hepatocytes: a comparative study.. Toxicology in vitro : an international journal published in association with BIBRA, 21 ((7)): (1307-1310). [PMID:17521864] |