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Guanine nucleotide exchange factors (GEFs)
1-((R)-11-(((R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethyl)amino)-9-methyl-1,2,3,4,4a,5-hexahydropyrazino[1′,2′:4,5][1,4]oxazino[3,2-g]quinazoline-3-carbonyl)cyclopropane-1-carbonitrile , CAS No.R609145, SOS Ras/Rac guanine nucleotide exchange factor 1

1-((R)-11-(((R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethyl)amino)-9-methyl-1,2,3,4,4a,5-hexahydropyrazino[1′,2′:4,5][1,4]oxazino[3,2-g]quinazoline-3-carbonyl)cyclopropane-1-carbonitrile , CAS No.R609145, SOS Ras/Rac guanine nucleotide exchange factor 1

Item Number

R609145

Grouped product items
SKU	Size	Availability	Price	Qty
R609145-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$360.90
R609145-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,250.90

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Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Mechanism of action	SOS Ras/Rac guanine nucleotide exchange factor 1

SOS1 Tchem Son of sevenless homolog 1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	1-((R)-11-(((R)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethyl)amino)-9-methyl-1,2,3,4,4a,5-hexahydropyrazino[1′,2′:4,5][1,4]oxazino[3,2-g]quinazoline-3-carbonyl)cyclopropane-1-carbonitrile
INCHI	InChI=1S/C28H27F3N6O2/c1-15(18-4-3-5-19(24(18)29)25(30)31)33-26-20-10-22-23(11-21(20)34-16(2)35-26)39-13-17-12-36(8-9-37(17)22)27(38)28(14-32)6-7-28/h3-5,10-11,15,17,25H,6-9,12-13H2,1-2H3,(H,33,34,35)/t15-,17-/m1/s1
InChi Key	KKFFOOWORPUAJB-NVXWUHKLSA-N
Canonical SMILES	Cc1nc2cc3OC[C@@H]4N(CCN(C(=O)C5(C#N)CC5)C4)c3cc2c(N[C@H](C)c2cccc(C(F)F)c2F)n1
Isomeric SMILES	CC1=NC2=CC3=C(C=C2C(=N1)N[C@H](C)C4=C(C(=CC=C4)C(F)F)F)N5CCN(C[C@@H]5CO3)C(=O)C6(CC6)C#N
PubChem CID	165437863

PubChem CID	165437863

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1. Zhang S, Zhang Y, Chen X, Xu J, Fang H, Li Y, Liu Y, He H. (2022) Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma.. J Med Chem, 71 (13): (1755-70). [PMID:36384290] [10.1021/acs.jmedchem.2c01517]

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