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SLC superfamily of solute carriers
10-(4-ethylphenyl)sulfonyl-N-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-7-amine , CAS No.E608844, Inhibitor of Erythrocyte urea transporter

10-(4-ethylphenyl)sulfonyl-N-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-7-amine , CAS No.E608844, Inhibitor of Erythrocyte urea transporter

Item Number

E608844

Grouped product items
SKU	Size	Availability	Price	Qty
E608844-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
E608844-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound 1a
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Erythrocyte urea transporter

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

INCHI	InChI=1S/C20H17N5O2S3/c1-2-13-5-7-15(8-6-13)30(26,27)20-19-22-18(21-12-14-4-3-10-28-14)17-16(9-11-29-17)25(19)24-23-20/h3-11H,2,12H2,1H3,(H,21,22)
InChi Key	UYFZCWXRMHSLTC-UHFFFAOYSA-N
Canonical SMILES	CCc1ccc(cc1)S(=O)(=O)c1nnn2c1nc(NCc1cccs1)c1c2ccs1
Isomeric SMILES	CCC1=CC=C(C=C1)S(=O)(=O)C2=C3N=C(C4=C(N3N=N2)C=CS4)NCC5=CC=CS5
PubChem CID	16019476

PubChem CID	16019476
ChEMBL Ligand	CHEMBL1394231

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1. Liu Y, Esteva-Font C, Yao C, Phuan PW, Verkman AS, Anderson MO. (2013) 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.. Bioorg Med Chem Lett, 23 (11): (3338-41). [PMID:23597791]

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