| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H304266-1g | 1g | In stock | $344.90 | |
| H304266-5g | 5g | In stock | $1,030.90 |
| Synonyms | 10-Hydroxycamptothecin | 64439-81-2 | (+/-)-10-Hydroxycamptothecin | Hydroxy camptothecine | 4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | ( inverted exclamation markA)-10-Hydroxycamptothecin | MFCD09027971 | 19-ethyl-7,19-di |
|---|---|
| Specifications & Purity | ≥98% |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | application： A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| IUPAC Name | 19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione |
|---|---|
| INCHI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3 |
| InChi Key | HAWSQZCWOQZXHI-UHFFFAOYSA-N |
| Canonical SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O |
| Isomeric SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O |
| PubChem CID | 4330531 |
| Molecular Weight | 364.35 |
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| Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
|---|---|
| Flash Point(°C) | 450.1ºC |
| Boil Point(°C) | 820.7ºC |
| Melt Point(°C) | 230-237°C |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
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| 1. Qingye Meng, Shuangling Zhong, Jia Wang, Yan Gao, Xuejun Cui. (2023) 10-hydroxycamptothecin-loaded starch-based microcapsules with the stepwise responsive release strategy for targeted controlled release. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126424). [PMID:37607650] |
| 2. Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107] |
| 3. Jialin Chen, Qingyun Mo, Qiuzi Long, Renwang Sheng, Zhixuan Chen, Yifan Luo, Chuanquan Liu, Ludvig J. Backman, Yanan Zhang, Wei Zhang. (2023) Hydroxycamptothecin and Substratum Stiffness Synergistically Regulate Fibrosis of Human Corneal Fibroblasts. ACS Biomaterials Science & Engineering, 9 (2): (959–967). [PMID:36705297] |
| 4. Li Tian, Zhou An-Di, Bai Li-Fei, Zhang Xiao-Yang, Zhou Yu-Ting, Yang Hai-Li, Xu Le-Tian, Guo Xin-Qin, Zhu Xi-Yu, Wang Dong-Jin, Gu Hong-Wei, Wang Xiao-Ming. (2022) Design, synthesis, and anticancer activity of three novel palbociclib derivatives. Frontiers in Oncology, 12 [PMID:36091173] |
| 5. Qiulan Zhang, Linghong Liu, Yongnian Ni. (2022) Magnetic reduced graphene oxide (MrGO) nanocomposites as nano carries for loading and transferring of 10-hydroxycamptothecin. JOURNAL OF MOLECULAR LIQUIDS, 362 (119680). [PMID:] |
| 6. Qiongzhe Ren, Xuefeng Tang, Yi Lu, Qing Li, Zhiqian Liao, Shinan Jiang, Haoli Zhang, Zhigang Xu, Lei Luo. (2022) Design, preparation and pharmacodynamics of ICG-Fe(Ⅲ) based HCPT nanocrystals against cancer. Asian Journal of Pharmaceutical Sciences, 17 (596). [PMID:36105312] |
| 7. Yuqiong Shi, Wei Liu, Xiangrong Wu, Jinhua Zhu, Danyang Zhou, Xiuhua Liu. (2021) A Water-Soluble Polyacid Polymer Based on Hydrophilic Metal–Organic Frameworks Using Amphoteric Carboxylic Acid Ligands as Linkers for Hydroxycamptothecin Loading and Release In Vitro. Nanomaterials, 11 (11): (2854). [PMID:34835619] |
| 1. Qingye Meng, Shuangling Zhong, Jia Wang, Yan Gao, Xuejun Cui. (2023) 10-hydroxycamptothecin-loaded starch-based microcapsules with the stepwise responsive release strategy for targeted controlled release. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126424). [PMID:37607650] |
| 2. Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107] |
| 3. Jialin Chen, Qingyun Mo, Qiuzi Long, Renwang Sheng, Zhixuan Chen, Yifan Luo, Chuanquan Liu, Ludvig J. Backman, Yanan Zhang, Wei Zhang. (2023) Hydroxycamptothecin and Substratum Stiffness Synergistically Regulate Fibrosis of Human Corneal Fibroblasts. ACS Biomaterials Science & Engineering, 9 (2): (959–967). [PMID:36705297] |
| 4. Li Tian, Zhou An-Di, Bai Li-Fei, Zhang Xiao-Yang, Zhou Yu-Ting, Yang Hai-Li, Xu Le-Tian, Guo Xin-Qin, Zhu Xi-Yu, Wang Dong-Jin, Gu Hong-Wei, Wang Xiao-Ming. (2022) Design, synthesis, and anticancer activity of three novel palbociclib derivatives. Frontiers in Oncology, 12 [PMID:36091173] |
| 5. Qiulan Zhang, Linghong Liu, Yongnian Ni. (2022) Magnetic reduced graphene oxide (MrGO) nanocomposites as nano carries for loading and transferring of 10-hydroxycamptothecin. JOURNAL OF MOLECULAR LIQUIDS, 362 (119680). [PMID:] |
| 6. Qiongzhe Ren, Xuefeng Tang, Yi Lu, Qing Li, Zhiqian Liao, Shinan Jiang, Haoli Zhang, Zhigang Xu, Lei Luo. (2022) Design, preparation and pharmacodynamics of ICG-Fe(Ⅲ) based HCPT nanocrystals against cancer. Asian Journal of Pharmaceutical Sciences, 17 (596). [PMID:36105312] |
| 7. Yuqiong Shi, Wei Liu, Xiangrong Wu, Jinhua Zhu, Danyang Zhou, Xiuhua Liu. (2021) A Water-Soluble Polyacid Polymer Based on Hydrophilic Metal–Organic Frameworks Using Amphoteric Carboxylic Acid Ligands as Linkers for Hydroxycamptothecin Loading and Release In Vitro. Nanomaterials, 11 (11): (2854). [PMID:34835619] |
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