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H425263-1ml

1ml

Available within 4-8 weeks(?)

$241.90

Basic Description

Synonyms	10-Hydroxycamptothecin \| 64439-81-2 \| (+/-)-10-Hydroxycamptothecin \| Hydroxy camptothecine \| 4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione \| ( inverted exclamation markA)-10-Hydroxycamptothecin \| MFCD09027971 \| 19-ethyl-7,19-di
Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMN1 Tchem Survival motor neuron protein (34246 Activities)

Discover Target: SMN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
INCHI	InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
InChi Key	HAWSQZCWOQZXHI-UHFFFAOYSA-N
Canonical SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
Isomeric SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
PubChem CID	4330531
Molecular Weight	364.35

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Flash Point(°C)	450.1ºC
Boil Point(°C)	820.7ºC
Melt Point(°C)	230-237°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

1. Qingye Meng, Shuangling Zhong, Jia Wang, Yan Gao, Xuejun Cui. (2023) 10-hydroxycamptothecin-loaded starch-based microcapsules with the stepwise responsive release strategy for targeted controlled release. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126424). [PMID:37607650]
2. Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107]
3. Jialin Chen, Qingyun Mo, Qiuzi Long, Renwang Sheng, Zhixuan Chen, Yifan Luo, Chuanquan Liu, Ludvig J. Backman, Yanan Zhang, Wei Zhang. (2023) Hydroxycamptothecin and Substratum Stiffness Synergistically Regulate Fibrosis of Human Corneal Fibroblasts. ACS Biomaterials Science & Engineering, 9 (2): (959–967). [PMID:36705297]
4. Li Tian, Zhou An-Di, Bai Li-Fei, Zhang Xiao-Yang, Zhou Yu-Ting, Yang Hai-Li, Xu Le-Tian, Guo Xin-Qin, Zhu Xi-Yu, Wang Dong-Jin, Gu Hong-Wei, Wang Xiao-Ming. (2022) Design, synthesis, and anticancer activity of three novel palbociclib derivatives. Frontiers in Oncology, 12 [PMID:36091173]
5. Qiulan Zhang, Linghong Liu, Yongnian Ni. (2022) Magnetic reduced graphene oxide (MrGO) nanocomposites as nano carries for loading and transferring of 10-hydroxycamptothecin. JOURNAL OF MOLECULAR LIQUIDS, 362 (119680). [PMID:]
6. Qiongzhe Ren, Xuefeng Tang, Yi Lu, Qing Li, Zhiqian Liao, Shinan Jiang, Haoli Zhang, Zhigang Xu, Lei Luo. (2022) Design, preparation and pharmacodynamics of ICG-Fe(Ⅲ) based HCPT nanocrystals against cancer. Asian Journal of Pharmaceutical Sciences, 17 (596). [PMID:36105312]
7. Yuqiong Shi, Wei Liu, Xiangrong Wu, Jinhua Zhu, Danyang Zhou, Xiuhua Liu. (2021) A Water-Soluble Polyacid Polymer Based on Hydrophilic Metal–Organic Frameworks Using Amphoteric Carboxylic Acid Ligands as Linkers for Hydroxycamptothecin Loading and Release In Vitro. Nanomaterials, 11 (11): (2854). [PMID:34835619]

References

1. Qingye Meng, Shuangling Zhong, Jia Wang, Yan Gao, Xuejun Cui. (2023) 10-hydroxycamptothecin-loaded starch-based microcapsules with the stepwise responsive release strategy for targeted controlled release. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126424). [PMID:37607650]
2. Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107]
3. Jialin Chen, Qingyun Mo, Qiuzi Long, Renwang Sheng, Zhixuan Chen, Yifan Luo, Chuanquan Liu, Ludvig J. Backman, Yanan Zhang, Wei Zhang. (2023) Hydroxycamptothecin and Substratum Stiffness Synergistically Regulate Fibrosis of Human Corneal Fibroblasts. ACS Biomaterials Science & Engineering, 9 (2): (959–967). [PMID:36705297]
4. Li Tian, Zhou An-Di, Bai Li-Fei, Zhang Xiao-Yang, Zhou Yu-Ting, Yang Hai-Li, Xu Le-Tian, Guo Xin-Qin, Zhu Xi-Yu, Wang Dong-Jin, Gu Hong-Wei, Wang Xiao-Ming. (2022) Design, synthesis, and anticancer activity of three novel palbociclib derivatives. Frontiers in Oncology, 12 [PMID:36091173]
5. Qiulan Zhang, Linghong Liu, Yongnian Ni. (2022) Magnetic reduced graphene oxide (MrGO) nanocomposites as nano carries for loading and transferring of 10-hydroxycamptothecin. JOURNAL OF MOLECULAR LIQUIDS, 362 (119680). [PMID:]
6. Qiongzhe Ren, Xuefeng Tang, Yi Lu, Qing Li, Zhiqian Liao, Shinan Jiang, Haoli Zhang, Zhigang Xu, Lei Luo. (2022) Design, preparation and pharmacodynamics of ICG-Fe(Ⅲ) based HCPT nanocrystals against cancer. Asian Journal of Pharmaceutical Sciences, 17 (596). [PMID:36105312]
7. Yuqiong Shi, Wei Liu, Xiangrong Wu, Jinhua Zhu, Danyang Zhou, Xiuhua Liu. (2021) A Water-Soluble Polyacid Polymer Based on Hydrophilic Metal–Organic Frameworks Using Amphoteric Carboxylic Acid Ligands as Linkers for Hydroxycamptothecin Loading and Release In Vitro. Nanomaterials, 11 (11): (2854). [PMID:34835619]

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10-Hydroxycamptothecin - 10mM in DMSO, high purity , CAS No.64439-81-2