10-Propargyl-5,8-dideazafolic acid , CAS No.76849-19-9

Item Number
P669303
Grouped product items
SKUSizeAvailabilityPrice Qty
P669303-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$999.90
P669303-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90

Basic Description

Synonyms10-propargyl-5,8-dideazafolic acid | CB3717 | TCMDC-131823 | PDDF | CHEBI:3258 | CB-3717 | CID 443388 | (2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid | CB3 | AC1L9EKK | BDBM18771 | AKOS040746670 | DB

Product Properties

ALogP0.6

Associated Targets(Human)

DHFR Tclin Dihydrofolate reductase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TYMS Tclin Thymidylate synthase (14 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DHFR Tclin Dihydrofolate reductase (3072 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYMS Tclin Thymidylate synthase (1651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC2A1 Tchem Glucose transporter (14755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
WIL2 (182 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (R7A) (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (RD1694) (36 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ht1 Hexose transporter 1 (14071 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-[[4-[(2-amino-4-oxo-3H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
INCHI InChI=1S/C24H23N5O6/c1-2-11-29(13-14-3-8-18-17(12-14)22(33)28-24(25)27-18)16-6-4-15(5-7-16)21(32)26-19(23(34)35)9-10-20(30)31/h1,3-8,12,19H,9-11,13H2,(H,26,32)(H,30,31)(H,34,35)(H3,25,27,28,33)/t19-/m0/s1
InChi Key LTKHPMDRMUCUEB-IBGZPJMESA-N
Canonical SMILES C#CCN(CC1=CC2=C(C=C1)N=C(NC2=O)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES C#CCN(CC1=CC2=C(C=C1)N=C(NC2=O)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID 135438608
Molecular Weight 477.5

Certificates

Certificate of Analysis(COA)

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Related Documents

Citations of This Product

1. Guohong Yao, Fenfang Li, Shengyi Dong.  (2023)  Solvent-free bulk soft material with low-temperature tolerance: Transparency, flexibility, stretchability, and adhesion.  CHEMICAL ENGINEERING SCIENCE,  281  (119164).  [PMID:] [10.1016/j.ces.2023.119164]
2. Li Gao, Huiying Zuo, Aikun Han, Yaming Sun, Xue Ma, Lijun He, Wenjie Zhao.  (2022)  Chromatographic Regulation by the Building Blocks for Triazine Polymer-Based Core–Shell Stationary Phases.  ACS Applied Polymer Materials,  (11): (8057–8064).  [PMID:] [10.1021/acsapm.2c00939]
3. Yongjin Ma, Xi Chen, Hanshuo Wu, Yanyang Shang, Pengfei Tan, Laidi Wu, Hong Wu, Jun Pan, Xiang Xiong.  (2017)  Highly efficient adsorption/photodegradation of organic pollutants using Sn1−0.25xCuxS2 flower-like as a novel photocatalyst.  JOURNAL OF ALLOYS AND COMPOUNDS,  702  (489).  [PMID:] [10.1016/j.jallcom.2017.01.266]

References

1. Guohong Yao, Fenfang Li, Shengyi Dong.  (2023)  Solvent-free bulk soft material with low-temperature tolerance: Transparency, flexibility, stretchability, and adhesion.  CHEMICAL ENGINEERING SCIENCE,  281  (119164).  [PMID:] [10.1016/j.ces.2023.119164]
2. Li Gao, Huiying Zuo, Aikun Han, Yaming Sun, Xue Ma, Lijun He, Wenjie Zhao.  (2022)  Chromatographic Regulation by the Building Blocks for Triazine Polymer-Based Core–Shell Stationary Phases.  ACS Applied Polymer Materials,  (11): (8057–8064).  [PMID:] [10.1021/acsapm.2c00939]
3. Yongjin Ma, Xi Chen, Hanshuo Wu, Yanyang Shang, Pengfei Tan, Laidi Wu, Hong Wu, Jun Pan, Xiang Xiong.  (2017)  Highly efficient adsorption/photodegradation of organic pollutants using Sn1−0.25xCuxS2 flower-like as a novel photocatalyst.  JOURNAL OF ALLOYS AND COMPOUNDS,  702  (489).  [PMID:] [10.1016/j.jallcom.2017.01.266]

Solution Calculators