12(S)-HPETE - 50 μg/ml in ethanol,≥98%, high purity , CAS No.71774-10-2, Activator of TRPV1

Item Number

H336047

• Synonyms: 12(S)-HPETE|71774-10-2|12S-HpETE|12-Hpete, (S)-|UNII-54G1W9LPV0|12-Hydroperoxyarachidonic acid, (S)-|54G1W9LPV0|(5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid|12-Hydroperoxyicosatetraenoate|12(S)-HpETE Lipid Maps(R) MS Standard|12-Hydro
• Specifications & Purity: Moligand™, ≥98%, 50 μg/ml in ethanol
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ACTIVATOR
• Mechanism of action: Activator of TRPV1

Product Description

12(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and is a potent and selective inhibitor of CaMKII (Ca|2+|/calmodulin-dependent protein kinase II) from rat brain cortex. Also inhibits TXA Synthase (thromboxane synthase) and platelet aggregation via activation of GCS (guanylate cyclase). 12(S)-HPETE is an activator of VR1.