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15(R)-Lipoxin A4 - ≥95%，~100ug/ml in ethanol, high purity , CAS No.171030-11-8, Agonist of FPR2/ALX
a LXA4 analog that is more potent and metabolically stable than LXA4 shown to block IL-8 release
Basic Description Synonyms GTPL3933 | (5S,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid | AKOS040755721 | aspirin triggered 15-epi lipoxin A4 | Q27074548 | AT-Lipoxin A4 | SCHEMBL1691709 | LMFA03040010 | Lipoxin A4, 15-epi | 15-epi-LXA4 | aspirin-triggered Specifications & Purity Moligand™, ≥95%, ~100ug/ml in ethanol Storage Temp Protected from light,Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of FPR2/ALX Product Description Lipoxin A4, 15-epi is an epimeric lipoxin A4 (catalog number sc-201060) analog that is more potent and metabolically stable than LXA4. Has been shown to exhibit anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte tafficking/infiltration. Lipoxin A4, 15-epi blocks TNF-a-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (5S,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid INCHI InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18-,19+/m1/s1 InChi Key IXAQOQZEOGMIQS-JEWNPAEBSA-N Canonical SMILES CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O Isomeric SMILES CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O Alternate CAS 171030-11-8 PubChem CID 9841438 MeSH Entry Terms 15-epi-lipoxin A4;15-epi-LXA4;5,6,15-tri-HETE;5,6,15-triHETE;5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid;lipoxin A4;LXA4 Molecular Weight 352.5
Chemical and Physical Properties Solubility Soluble in DMSO (~50 mg/ml), DMF (~50 mg/ml), and PBS pH 7.2 (~1 mg/ml). Sensitivity Light sensitive Refractive Index n20D~1.54 (Predicted) Boil Point(°C) 78° C
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E2323280