Skip to the beginning of the images gallery

17-AAG - 98%, high purity , CAS No.75747-14-7

≥98%

CAS#: 75747-14-7
Formula: C₃₁H₄₃N₃O₈
Molecular Weight: 585.69
MDL number: MFCD04973892
PubChem CID: 6505803

Item Number

A126970

Grouped product items
SKU	Size	Availability	Price
A126970-5mg	5mg	In stock	$28.90
A126970-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$117.90
A126970-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$296.90

Potent, selective HSP90 inhibitor

Basic Description

Synonyms	Tanespimycin \| 75747-14-7 \| 17-AAG \| 17-(Allylamino)-17-demethoxygeldanamycin \| 17AAG \| NSC-330507 \| 17-(Allylamino)geldanamycin \| KOS-953 \| 17-Allylaminogeldanamycin \| Cp 127374 \| NSC 330507 \| 17-Demethoxy-17-allylamino geldanamycin \| BMS-722782 \| Tanespimycin [USAN] \| CHEBI:64153 \|
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. A potent Hsp90 inhibitor for tumor cells

Associated Targets(Human)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha (24 Activities)

Discover Target: HSP90AA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AB1 Tchem Heat shock protein HSP 90-beta (11 Activities)

Discover Target: HSP90AB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
INCHI	InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
InChi Key	AYUNIORJHRXIBJ-TXHRRWQRSA-N
Canonical SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\C)C)O)OC
WGK Germany	3
PubChem CID	6505803
Molecular Weight	585.69

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
C2204017	Certificate of Analysis	Dec 21, 2023	A126970
C2204034	Certificate of Analysis	Dec 21, 2023	A126970
C2204067	Certificate of Analysis	Dec 21, 2023	A126970
C1512029	Certificate of Analysis	Nov 18, 2022	A126970

Solubility

Soluble in DMSO (≥20 mg/ml at 25 °C), methanol (10 mg/ml), chloroform (10 mg/ml yielding a clear purple solution), water (<1 mg/ml at 25 °C), and ethanol (≥5 mg/ml at 25 °C).

Sensitivity

Light sensitive

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

17-AAG - 98%, high purity , CAS No.75747-14-7

Basic Description

Associated Targets(Human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator