Basic Description

Synonyms	Ercalcitriol \| 60133-18-8 \| 1,25-Dihydroxycalciferol \| 1alpha,25-Dihydroxyvitamin D2 \| 1,25-Dihydroxyergocalciferol \| 1,25-Dihydroxyvitamin D2 \| 1alpha,25-Dihydroxycalciferol \| 1alpha,25-dihydroxyergocalciferol \| RO-17-6218 \| 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-
Specifications & Purity	≥95%, 100 μg/mL in ethanol
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	General Description 1α,25-Dihydroxyvitamin D 2 is an active form of vitamin D 2 . It is also known as ercalcitriol or 1α,25-dihydroxyergocalciferol. It was first isolated from mitochondria of chick kidney.

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
INCHI	InChI=1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1
InChi Key	ZGLHBRQAEXKACO-XJRQOBMKSA-N
Canonical SMILES	CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES	C[C@H](/C=C/[C@H](C)C(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
WGK Germany	3
PubChem CID	9547243
Molecular Weight	428.65
Beilstein	5635017

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H311:Toxic in contact with skin H330:Fatal if inhaled H372:Causes damage to organs through prolonged or repeated exposure H301+H311:Toxic if swallowed or in contact with skin
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	3

References

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47. Kazuki Shimizu,Akira Kawase,Tsuyoshi Haneishi,Yasuharu Kato,Kazutomo Kinoshita,Masayuki Ohmori,Yoshiyuki Furuta,Takashi Emura,Nobuaki Kato,Tetsuya Mitsui,Koji Yamaguchi,Keiichi Morita,Nobuo Sekiguchi,Tessai Yamamoto,Tomochika Matsushita,Shin Shimaoka,Atsuko Sugita,Kazumi Morikawa. (2006-04-25) Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures.. Bioorganic & medicinal chemistry letters, 16 ((12)): (3323-3329). [PMID:16630723]
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52. Nancy Noyola-Martínez,Lorenza Díaz,Verónica Zaga-Clavellina,Euclides Avila,Ali Halhali,Fernando Larrea,David Barrera. (2013-12-24) Regulation of CYP27B1 and CYP24A1 gene expression by recombinant pro-inflammatory cytokines in cultured human trophoblasts.. The Journal of steroid biochemistry and molecular biology, 144 Pt A (106-109). [PMID:24361583]
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54. Hideki Sugimoto,Kiyoko Watanabe,Toshizo Toyama,Shun-suke Takahashi,Shuta Sugiyama,Masaichi-Chang-il Lee,Nobushiro Hamada. (2014-10-23) Inhibitory effects of French pine bark extract, Pycnogenol®, on alveolar bone resorption and on the osteoclast differentiation.. Phytotherapy research : PTR, 29 ((2)): (251-259). [PMID:25336411]
55. K Afsal,M Harishankar,V V Banurekha,N Meenakshi,R T Parthasarathy,P Selvaraj. (2014-12-03) Effect of 1,25-dihydroxy vitamin D3 on cathelicidin expression in patients with and without cavitary tuberculosis.. Tuberculosis (Edinburgh, Scotland), 94 ((6)): (599-605). [PMID:25459161]
56. Ting Chen,Dangsheng Huang,Guanghui Chen,Tingshu Yang,Jun Yi,Miao Tian. (2014-12-04) Efficient and sustained IGF-1 expression in the adipose tissue-derived stem cells mediated via a lentiviral vector.. Journal of molecular histology, 46 ((1)): (1-11). [PMID:25467975]
57. Marc Thill,Alena Woeste,Kathrin Reichert,Dorothea Fischer,Achim Rody,Michael Friedrich,Frank Köster. (2015-02-11) Vitamin D inhibits ovarian cancer cell line proliferation in combination with celecoxib and suppresses cyclooxygenase-2 expression.. Anticancer research, 35 ((2)): (1197-1203). [PMID:25667511]
58. Ela Haddur,Ali Burak Ozkaya,Handan Ak,Hikmet Hakan Aydin. (2015-04-29) The effect of calcitriol on endoplasmic reticulum stress response.. Biochemistry and cell biology = Biochimie et biologie cellulaire, 93 ((3)): (268-271). [PMID:25916601]
59. Z L Zhang,E Y Liao,W B Xia,H Lin,Q Cheng,L Wang,Y Q Hao,D C Chen,H Tang,Y De Peng,L You,L He,Z H Hu,C L Song,F Wei,J Wang,L Zhang,A C Santora. (2015-05-02) Alendronate sodium/vitamin D3 combination tablet versus calcitriol for osteoporosis in Chinese postmenopausal women: a 6-month, randomized, open-label, active-comparator-controlled study with a 6-month extension.. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26 ((9)): (2365-2374). [PMID:25929192]
60. Justyna Trynda,Eliza Turlej,Magdalena Milczarek,Anita Pietraszek,Michał Chodyński,Andrzej Kutner,Joanna Wietrzyk. (2015-10-23) Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol.. International journal of molecular sciences, 16 ((10)): (24873-24894). [PMID:26492238]
61. Zhichao Liu,Qiang Shi,Don Ding,Reagan Kelly,Hong Fang,Weida Tong. (2011-12-24) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).. PLoS computational biology, 7 ((12)): (e1002310-e1002310). [PMID:22194678]

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1α,25-Dihydroxyvitamin D₂ solution - 100 μg/mL in ethanol, 95% (CP), high purity , CAS No.60133-18-8