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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | 2,2,2-Tribromoethanol | 75-80-9 | Tribromoethanol | Tribromoethyl alcohol | Avertin | Bromethol | Ethobrome | Tribromethanol | Basibrol | Ethobrom | Narcolan | Narcotyl | Narkolan | Rectanol | ETHANOL, 2,2,2-TRIBROMO- | 2,2,2-Tribromoethyl alcohol | .beta.-Tribromoethanol | NSC 2189 | 1329- |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | 2,2,2-Tribromoethanol is generally used as an anesthetic drug for rodents |
Associated Targets(Human)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
POLK Tbio DNA polymerase kappa (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
POLK Tbio DNA polymerase kappa (8653 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
rep Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | 2,2,2-tribromoethanol |
|---|---|
| INCHI | InChI=1S/C2H3Br3O/c3-2(4,5)1-6/h6H,1H2 |
| InChi Key | YFDSDPIBEUFTMI-UHFFFAOYSA-N |
| Canonical SMILES | C(C(Br)(Br)Br)O |
| Isomeric SMILES | C(C(Br)(Br)Br)O |
| WGK Germany | 3 |
| RTECS | KM3675000 |
| PubChem CID | 6400 |
| Molecular Weight | 282.76 |
| Reaxy-Rn | 1733249 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Sensitivity | air&light sensitive |
|---|---|
| Boil Point(°C) | 94°C/11mmHg |
| Melt Point(°C) | 73°C-83.0 °C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
| WGK Germany | 3 |
| RTECS | KM3675000 |
| Reaxy-Rn | 1733249 |
Related Documents
Citations of This Product
| 1. Chaofeng Xing, Minyi Tang, Jianqin Yang, Shuai Wang, Qihua Xu, Wenbin Feng, Yunping Mu, Fanghong Li, Allan Zijian Zhao. (2023) Eicosapentaenoic acid metabolites promotes the trans-differentiation of pancreatic α cells to β cells. BIOCHEMICAL PHARMACOLOGY, 216 (115775). [PMID:37659738] [10.1016/j.bcp.2023.115775] |
| 2. Xiaoyu Zhang, Yuan Gao, Zhuangzhuang Liu, Wenjing Li, Yuan Kang, Ximeng Li, Zhenlu Xu, Cheng Peng, Yun Qi. (2023) Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (1): (320). [PMID:36613764] [10.3390/ijms24010320] |
| 3. Xiaoyan Wan, Xiaomei He, Qian Liu, Xiaotong Wang, Xiaofang Ding, Honggang Li. (2020) Frequent and mild scrotal heat stress in mice epigenetically alters glucose metabolism in the male offspring. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 319 (2): (E291-E304). [PMID:32603600] [10.1152/ajpendo.00038.2020] |
| 4. Xiaoyan Wan, Xiaomei He, Qian Liu, Peng Duan, Honggang Li. (2020) Frequent and mild scrotal heat stress impairs embryo development, implantation and offspring sex ratio in mice. REPRODUCTIVE BIOMEDICINE ONLINE, 40 (617). [PMID:32276888] [10.1016/j.rbmo.2020.01.020] |
References
| 1. Chaofeng Xing, Minyi Tang, Jianqin Yang, Shuai Wang, Qihua Xu, Wenbin Feng, Yunping Mu, Fanghong Li, Allan Zijian Zhao. (2023) Eicosapentaenoic acid metabolites promotes the trans-differentiation of pancreatic α cells to β cells. BIOCHEMICAL PHARMACOLOGY, 216 (115775). [PMID:37659738] [10.1016/j.bcp.2023.115775] |
| 2. Xiaoyu Zhang, Yuan Gao, Zhuangzhuang Liu, Wenjing Li, Yuan Kang, Ximeng Li, Zhenlu Xu, Cheng Peng, Yun Qi. (2023) Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (1): (320). [PMID:36613764] [10.3390/ijms24010320] |
| 3. Xiaoyan Wan, Xiaomei He, Qian Liu, Xiaotong Wang, Xiaofang Ding, Honggang Li. (2020) Frequent and mild scrotal heat stress in mice epigenetically alters glucose metabolism in the male offspring. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 319 (2): (E291-E304). [PMID:32603600] [10.1152/ajpendo.00038.2020] |
| 4. Xiaoyan Wan, Xiaomei He, Qian Liu, Peng Duan, Honggang Li. (2020) Frequent and mild scrotal heat stress impairs embryo development, implantation and offspring sex ratio in mice. REPRODUCTIVE BIOMEDICINE ONLINE, 40 (617). [PMID:32276888] [10.1016/j.rbmo.2020.01.020] |