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Targets
Kinases
CK1: Casein kinase 1
2-[2-(4-fluoro-2-methylphenoxymethyl)-5-methoxypyridin-4-yl]-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one , CAS No.F608728, Inhibitor of casein kinase 1 alpha 1;Inhibitor of casein kinase 1 delta;Inhibitor of casein kinase 1 gamma 2

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2-[2-(4-fluoro-2-methylphenoxymethyl)-5-methoxypyridin-4-yl]-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one , CAS No.F608728, Inhibitor of casein kinase 1 alpha 1;Inhibitor of casein kinase 1 delta;Inhibitor of casein kinase 1 gamma 2

Moligand™

PubChem CID: 71461150

Item Number

F608728

Grouped product items
SKU	Size	Availability	Price	Qty
F608728-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$246.90
F608728-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$858.90

View related series

casein kinase 1 alpha 1 Inhibitor casein kinase 1 delta Inhibitor casein kinase 1 gamma 2 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of casein kinase 1 alpha 1;Inhibitor of casein kinase 1 delta;Inhibitor of casein kinase 1 gamma 2

Associated Targets(Human)

CSNK1D Tchem Casein kinase I isoform delta (1 Activities)

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1G2 Tchem Casein kinase I isoform gamma-2 (2 Activities)

Discover Target: CSNK1G2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1A1 Tchem Casein kinase I isoform alpha (1 Activities)

Discover Target: CSNK1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1D Tchem Casein kinase I delta (4546 Activities)

Discover Target: CSNK1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1G2 Tchem Casein kinase I gamma 2 (2539 Activities)

Discover Target: CSNK1G2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1A1 Tchem Casein kinase I alpha (2581 Activities)

Discover Target: CSNK1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-[2-(4-fluoro-2-methylphenoxymethyl)-5-methoxypyridin-4-yl]-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one
INCHI	InChI=1S/C21H20FN3O3/c1-12-7-13(22)3-4-19(12)28-11-14-8-15(20(27-2)10-24-14)18-9-16-17(25-18)5-6-23-21(16)26/h3-4,7-10,25H,5-6,11H2,1-2H3,(H,23,26)
InChi Key	WYOFSHLAFWJJAZ-UHFFFAOYSA-N
Canonical SMILES	COc1cnc(cc1c1cc2c([nH]1)CCNC2=O)COc1ccc(cc1C)F
Isomeric SMILES	CC1=C(C=CC(=C1)F)OCC2=CC(=C(C=N2)OC)C3=CC4=C(N3)CCNC4=O
PubChem CID	71461150

Database links

ChEMBL Ligand	CHEMBL2203564
BindingDB Ligand	50400754
PubChem CID	71461150

Certificates

Certificate of Analysis(COA)

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References

1. Huang H, Acquaviva L, Berry V, Bregman H, Chakka N, O'Connor A, DiMauro EF, Dovey J, Epstein O, Grubinska B et al.. (2012) Structure-Based Design of Potent and Selective CK1γ Inhibitors.. ACS Med Chem Lett, 3 (12): (1059-64). [PMID:24900428] [10.1021/op500134e]

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