Basic Description

Synonyms	19171-18-7 \| 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione \| 4-Nitrothalidomide \| 3-Nitrothalidomide \| 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-nitro- \| 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindole-1,3-dione \| Phthalimide, N-(2,6-dioxo-3-p
Specifications & Purity	≥99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

CRBN Tclin Protein cereblon (0 Activities)

Discover Target: CRBN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HUVEC (11049 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1A1 Tchem Cereblon/Casein kinase I alpha (35 Activities)

Discover Target: CSNK1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cereblon isoform 4 (52 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488187827
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488187827
IUPAC Name	2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindole-1,3-dione
INCHI	InChI=1S/C13H9N3O6/c17-9-5-4-8(11(18)14-9)15-12(19)6-2-1-3-7(16(21)22)10(6)13(15)20/h1-3,8H,4-5H2,(H,14,17,18)
InChi Key	KVRCAGKHAZRSQX-UHFFFAOYSA-N
Canonical SMILES	C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)[N+](=O)[O-]
Isomeric SMILES	C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)[N+](=O)[O-]
PubChem CID	134775
Molecular Weight	303.23

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
G2313498	Certificate of Analysis	Jul 26, 2023	D489571
G2313510	Certificate of Analysis	Jul 26, 2023	D489571
G2313492	Certificate of Analysis	Jul 25, 2023	D489571
G2313497	Certificate of Analysis	Jul 25, 2023	D489571
G2313499	Certificate of Analysis	Jul 25, 2023	D489571
G2313501	Certificate of Analysis	Jul 25, 2023	D489571
G2313508	Certificate of Analysis	Jul 25, 2023	D489571
G2313509	Certificate of Analysis	Jul 25, 2023	D489571
G2214009	Certificate of Analysis	Jul 19, 2022	D489571
G2214010	Certificate of Analysis	Jul 18, 2022	D489571

Chemical and Physical Properties

Flash Point(°C)	318.7°C
Boil Point(°C)	603.4±50.0 °C
Melt Point(°C)	>200°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

FAQs and Articles

FAQ

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Solution Calculators

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SKU	Size	Availability	Price
D489571-10mg	10mg	In stock	$9.90
D489571-50mg	50mg	In stock	$15.90
D489571-250mg	250mg	In stock	$20.90
D489571-1g	1g	In stock	$22.90
D489571-5g	5g	In stock	$99.90

2-(2,6-Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione - 99%, high purity , CAS No.19171-18-7