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2,2'-Bipyridyl - 99%, high purity , CAS No.366-18-7

209 Citations
  • AR
    •
  • ≥99%
Item Number
D108977
Grouped product items
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D108977-5g
5g
In stock
$15.90
D108977-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$24.90
D108977-25g
25g
In stock
$46.90
D108977-100g
100g
In stock
$150.90
D108977-500g
500g
In stock
$447.90
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Metalloprotease inhibitor; high-affinity chelator of iron.

View related series
Biochemical Assay Reagents Nitrogen donating ligand Organic linker molecule

Basic Description

Synonyms2,2'-Dipyridyl | 2,2′-Dipyridine | 2,2'-Bipyridine
Specifications & PurityAR, ≥99%
Biochemical and Physiological MechanismsSymmetrical bipyridine commonly used as a neutral ligand for chelating with metal ions. Metalloprotease inhibitor. High-affinity chelator of iron. May inhibit Fe 2+ containing enzymes at 10 −8 M.
Storage TempProtected from light
Shipped InNormal
GradeAR
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

2,2'-Dipyridyl is a metalloprotease inhibitor that is also a high-affinity chelator of iron. It may inhibit Fe2+ containing enzymes at 10-8 M.
A high-affinity chelator of iron

Associated Targets(Human)

METAP1 Tchem Methionine aminopeptidase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
METAP1 Tchem Methionine aminopeptidase 1 (614 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCR1 Tchem C-C chemokine receptor type 1 (1730 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCR5 Tclin C-C chemokine receptor type 5 (5640 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P4HTM Tchem Hypoxia-inducible factor prolyl 4-hydroxylase (111 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2780 (11979 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCR8 Tchem C-C chemokine receptor type 8 (339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P4HA1 Tchem Prolyl 4-hydroxylase subunit alpha-1 (16 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FNTA Tclin Protein farnesyltransferase (3470 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Histidine-rich protein (528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella aerogenes (4963 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ferriprotoporphyrin IX (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Deoxyhypusine hydroxylase (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488179622
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179622
IUPAC Name 2-pyridin-2-ylpyridine
INCHI InChI=1S/C10H8N2/c1-3-7-11-9(5-1)10-6-2-4-8-12-10/h1-8H
InChi Key ROFVEXUMMXZLPA-UHFFFAOYSA-N
Canonical SMILES C1=CC=NC(=C1)C2=CC=CC=N2
Isomeric SMILES C1=CC=NC(=C1)C2=CC=CC=N2
RTECS DW1750000
PubChem CID 1474
UN Number 2811
Packing Group III
Molecular Weight 156.19
Beilstein 23199
Reaxy-Rn 113089

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

33 results found

Lot NumberCertificate TypeDateItem
K2429033Certificate of AnalysisNov 01, 2024 D108977
K2425536Certificate of AnalysisNov 01, 2024 D108977
K2425324Certificate of AnalysisNov 01, 2024 D108977
K2425323Certificate of AnalysisNov 01, 2024 D108977
K2425322Certificate of AnalysisNov 01, 2024 D108977
E2409181Certificate of AnalysisApr 22, 2024 D108977
E2409180Certificate of AnalysisApr 22, 2024 D108977
E2409179Certificate of AnalysisApr 22, 2024 D108977
D2407189Certificate of AnalysisMar 16, 2024 D108977
D2407190Certificate of AnalysisMar 16, 2024 D108977
D2407191Certificate of AnalysisMar 16, 2024 D108977
B2328197Certificate of AnalysisMar 11, 2023 D108977
F2315961Certificate of AnalysisMar 09, 2023 D108977
B2328193Certificate of AnalysisMar 09, 2023 D108977
B2302417Certificate of AnalysisFeb 07, 2023 D108977
I2220323Certificate of AnalysisMar 23, 2022 D108977
I2220366Certificate of AnalysisMar 23, 2022 D108977
I2220328Certificate of AnalysisMar 23, 2022 D108977
I2220326Certificate of AnalysisMar 23, 2022 D108977
I2220324Certificate of AnalysisMar 23, 2022 D108977
G2416039Certificate of AnalysisMar 23, 2022 D108977
G2329044Certificate of AnalysisMar 23, 2022 D108977
G2329034Certificate of AnalysisMar 23, 2022 D108977
F2420040Certificate of AnalysisMar 23, 2022 D108977
A2418087Certificate of AnalysisMar 23, 2022 D108977
F2315951Certificate of AnalysisMar 23, 2022 D108977
G2329038Certificate of AnalysisDec 22, 2021 D108977
G2304020Certificate of AnalysisDec 22, 2021 D108977
B2212314Certificate of AnalysisDec 22, 2021 D108977
B2212312Certificate of AnalysisDec 22, 2021 D108977
B2212215Certificate of AnalysisDec 22, 2021 D108977
B2212214Certificate of AnalysisDec 22, 2021 D108977
B2212213Certificate of AnalysisDec 22, 2021 D108977

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Chemical and Physical Properties

SolubilitySoluble in 100 mg/ml ethanol,
SensitivityLight sensitive.
Boil Point(°C)272.5°C
Melt Point(°C)69.5°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H301:Toxic if swallowed

H341:Suspected of causing genetic defects

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/...

P302+P352:IF ON SKIN: wash with plenty of water.

P405:Store locked up.

P501:Dispose of contents/container to ...

P312:Call a POISON CENTER or doctor/... if you feel unwell.

P264:Wash hands [and …] thoroughly after handling.

P201:Obtain special instructions before use.

P308+P313:IF exposed or concerned: Get medical advice/attention.

P270:Do not eat, drink or smoke when using this product.

P337+P313:IF eye irritation persists: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

P202:Do not handle until all safety precautions have been read and understood.

P330:Rinse mouth.

RTECS DW1750000
Reaxy-Rn 113089
Class 6.1
Merck Index 3347

Related Documents

 SDS

 Specification Sheet

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    2,2'-Bipyridyl
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