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Cytochrome P450
2-[(2-bromophenyl)methyl]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one , CAS No.B609253, Inhibitor of CYP24A1;Inhibitor of CYP27A1

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2-[(2-bromophenyl)methyl]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one , CAS No.B609253, Inhibitor of CYP24A1;Inhibitor of CYP27A1

Moligand™

PubChem CID: 46945265

Item Number

B609253

Grouped product items
SKU	Size	Availability	Price	Qty
B609253-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
B609253-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

CYP24A1 Inhibitor CYP27A1 Inhibitor

Basic Description

Synonyms	compound 4d
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of CYP24A1;Inhibitor of CYP27A1

Associated Targets(Human)

CYP27A1 Tchem Sterol 26-hydroxylase, mitochondrial (2 Activities)

Discover Target: CYP27A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP24A1 Tchem 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (1 Activities)

Discover Target: CYP24A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP27A1 Tchem Sterol 26-hydroxylase, mitochondrial (9 Activities)

Discover Target: CYP27A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cyp24a1 Cytochrome P450 24A1 (20 Activities)

Discover Target: Cyp24a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[(2-bromophenyl)methyl]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
INCHI	InChI=1S/C18H17BrO2/c1-21-15-8-9-16-12(11-15)6-7-14(18(16)20)10-13-4-2-3-5-17(13)19/h2-5,8-9,11,14H,6-7,10H2,1H3
InChi Key	GKGZPFKBDIIBHB-UHFFFAOYSA-N
Canonical SMILES	COc1ccc2c(c1)CCC(C2=O)Cc1ccccc1Br
Isomeric SMILES	COC1=CC2=C(C=C1)C(=O)C(CC2)CC3=CC=CC=C3Br
PubChem CID	46945265

Database links

PubChem CID	46945265
ChEMBL Ligand	CHEMBL1253946

Certificates

Certificate of Analysis(COA)

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References

1. Aboraia AS, Makowski B, Bahja A, Prosser D, Brancale A, Jones G, Simons C. (2010) Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones.. Eur J Med Chem, 45 (10): (4427-34). [PMID:20655626]

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