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Cytochrome P450
2-[(2-bromophenyl)methyl]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one , CAS No.B609253, Inhibitor of CYP24A1;Inhibitor of CYP27A1

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2-[(2-bromophenyl)methyl]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one , CAS No.B609253, Inhibitor of CYP24A1;Inhibitor of CYP27A1

Moligand™

PubChem CID: 46945265

Item Number

B609253

Grouped product items
SKU	Size	Availability	Price	Qty
B609253-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
B609253-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

CYP24A1 Inhibitor CYP27A1 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of CYP24A1;Inhibitor of CYP27A1

Associated Targets(Human)

CYP27A1 Tchem Sterol 26-hydroxylase, mitochondrial (2 Activities)

Discover Target: CYP27A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP24A1 Tchem 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (1 Activities)

Discover Target: CYP24A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP27A1 Tchem Sterol 26-hydroxylase, mitochondrial (9 Activities)

Discover Target: CYP27A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cyp24a1 Cytochrome P450 24A1 (20 Activities)

Discover Target: Cyp24a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-[(2-bromophenyl)methyl]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
INCHI	InChI=1S/C18H17BrO2/c1-21-15-8-9-16-12(11-15)6-7-14(18(16)20)10-13-4-2-3-5-17(13)19/h2-5,8-9,11,14H,6-7,10H2,1H3
InChi Key	GKGZPFKBDIIBHB-UHFFFAOYSA-N
Canonical SMILES	COc1ccc2c(c1)CCC(C2=O)Cc1ccccc1Br
Isomeric SMILES	COC1=CC2=C(C=C1)C(=O)C(CC2)CC3=CC=CC=C3Br
PubChem CID	46945265

Database links

PubChem CID	46945265
ChEMBL Ligand	CHEMBL1253946

Certificates

Certificate of Analysis(COA)

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References

1. Aboraia AS, Makowski B, Bahja A, Prosser D, Brancale A, Jones G, Simons C. (2010) Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones.. Eur J Med Chem, 45 (10): (4427-34). [PMID:20655626]

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