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2-(2-cyclopropaneamidopyridin-4-yl)-4-methoxy-N-{3-[(1,2,3,4-tetrahydroacridin-9-yl)amino]propyl}-1,3-thiazole-5-carboxamide , CAS No.C609061, Inhibitor of acetylcholinesterase (Cartwright blood group);Inhibitor of glycogen synthase kinase 3 beta
Basic Description Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of acetylcholinesterase (Cartwright blood group);Inhibitor of glycogen synthase kinase 3 beta
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-(2-cyclopropaneamidopyridin-4-yl)-4-methoxy-N-{3-[(1,2,3,4-tetrahydroacridin-9-yl)amino]propyl}-1,3-thiazole-5-carboxamide INCHI InChI=1S/C30H32N6O3S/c1-39-29-26(40-30(36-29)19-13-16-31-24(17-19)35-27(37)18-11-12-18)28(38)33-15-6-14-32-25-20-7-2-4-9-22(20)34-23-10-5-3-8-21(23)25/h2,4,7,9,13,16-18H,3,5-6,8,10-12,14-15H2,1H3,(H,32,34)(H,33,38)(H,31,35,37) InChi Key XYSJVXMQSXKJCN-UHFFFAOYSA-N Canonical SMILES COc1nc(sc1C(=O)NCCCNc1c2CCCCc2nc2c1cccc2)c1ccnc(c1)NC(=O)C1CC1 Isomeric SMILES COC1=C(SC(=N1)C2=CC(=NC=C2)NC(=O)C3CC3)C(=O)NCCCNC4=C5CCCCC5=NC6=CC=CC=C64 PubChem CID 132427688
References 1. Jiang XY, Chen TK, Zhou JT, He SY, Yang HY, Chen Y, Qu W, Feng F, Sun HP. (2018) Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.. ACS Med Chem Lett, 9 (3): (171-176). [PMID:29541355 ] [10.1021/op500134e ]
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