Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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D102023-5ml | 5ml | In stock | $9.90 | |
D102023-25ml | 25ml | In stock | $26.90 | |
D102023-100ml | 100ml | In stock | $95.90 | |
D102023-500ml | 500ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $266.90 |
Synonyms | FT-0609269 | 1219804-04-2 | Butanoic acid, 2,2-dimethyl- | EC 209-865-0 | 2.2-Dimethylbutyric acid | AKOS009158866 | Dimebutic Acid | Tox21_200740 | Q27117928 | W-105316 | alpha,alpha-Dimethylbutyric acid | HMS3039B09 | InChI=1/C6H12O2/c1-4-6(2,3)5(7)8/h4 |
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Specifications & Purity | ≥98% |
Storage Temp | Argon charged |
Shipped In | Normal |
Note | 5ml卖完停产,不再备货 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2,2-dimethylbutanoic acid |
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INCHI | InChI=1S/C6H12O2/c1-4-6(2,3)5(7)8/h4H2,1-3H3,(H,7,8) |
InChi Key | VUAXHMVRKOTJKP-UHFFFAOYSA-N |
Canonical SMILES | CCC(C)(C)C(=O)O |
Isomeric SMILES | CCC(C)(C)C(=O)O |
WGK Germany | 3 |
PubChem CID | 11684 |
UN Number | 3265 |
Molecular Weight | 116.16 |
Beilstein | 2335 |
Reaxy-Rn | 1720666 |
Enter Lot Number to search for COA:
Solubility | Slightly soluble in water |
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Sensitivity | Air sensitive |
Refractive Index | 1.4154 |
Flash Point(°F) | 174.2 °F |
Flash Point(°C) | 79 °C |
Boil Point(°C) | 94-96°C |
Melt Point(°C) | -14℃ |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Reaxy-Rn | 1720666 |
1. N Uchiyama,Y Kagami,Y Saito,S Abe,M Ohtawa,S Hata. (1991-07-01) Metabolic fate of 2,2-dimethylbutyryl moiety of simvastatin in rats: identification of metabolites by gas chromatography/mass spectrometry.. European journal of drug metabolism and pharmacokinetics, 16 ((3)): (189-196). [PMID:1814736] |
2. Yan-li Tang,Yan-ru Deng,Han-qing Wang. (2004-05-14) [Chemical components of essential oils from the herb of Ligularia virgaurea].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 28 ((7)): (627-629). [PMID:15139106] |
3. Robert A Parise,Jan H Beumer,Cyrous O Kangani,Julianne L Holleran,Julie L Eiseman,Nicola F Smith,Joseph M Covey,Susan P Perrine,Merrill J Egorin. (2007-12-25) Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 862 ((1-2)): (168-174). [PMID:18155649] |
4. Susan P Perrine,William A Wargin,Michael S Boosalis,Wayne J Wallis,Sally Case,Jeffrey R Keefer,Douglas V Faller,William C Welch,Ronald J Berenson. (2011-03-23) Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.. Journal of clinical pharmacology, 51 ((8)): (1186-1194). [PMID:21422239] |
5. Pramod S Terse,Jerry D Johnson,Michael A Hawk,Glenn D Ritchie,Michael J Ryan,Daphne Y Vasconcelos,Denise A Contos,Susan P Perrine,James O Peggins,Joseph E Tomaszewski. (2011-05-12) Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats.. Toxicologic pathology, 39 ((4)): (614-622). [PMID:21558467] |
6. Suthat Fucharoen,Adlette Inati,Noppadol Siritanaratku,Swee L Thein,William C Wargin,Suzanne Koussa,Ali Taher,Nattawara Chaneim,Michael Boosalis,Ronald Berenson,Susan P Perrine. (2013-03-28) A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.. British journal of haematology, 161 ((4)): (587-593). [PMID:23530969] |
7. Abdullah Kutlar,Marvin E Reid,Adlette Inati,Ali T Taher,Miguel R Abboud,Amal El-Beshlawy,George R Buchanan,Hedy Smith,Kenneth I Ataga,Susan P Perrine,Richard G Ghalie. (2013-07-06) A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.. American journal of hematology, 88 ((11)): (E255-E260). [PMID:23828223] |
8. James Chun Yip Chan,Dorinda Yan Qin Kioh,Gaik Chin Yap,Bee Wah Lee,Eric Chun Yong Chan. (2017-02-09) A novel LCMSMS method for quantitative measurement of short-chain fatty acids in human stool derivatized with. Journal of pharmaceutical and biomedical analysis, 138 (43-53). [PMID:28178633] |
9. Yukako Okazaki,Tetsuyuki Katayama. (2018-11-08) Consumption of non-digestible oligosaccharides elevates colonic alkaline phosphatase activity by up-regulating the expression of IAP-I, with increased mucins and microbial fermentation in rats fed a high-fat diet.. The British journal of nutrition, 121 ((2)): (146-154). [PMID:30400998] |
10. Changcheng Sun,Keke Tang,Jing Wu,Han Xu,Wenfeng Zhang,Tiantian Cao,Yang Zhou,Tian Yu,Anan Li. (2019-05-31) Leptin modulates olfactory discrimination and neural activity in the olfactory bulb.. Acta physiologica (Oxford, England), 227 ((2)): (e13319-e13319). [PMID:31144469] |
11. Wen Lie,Eleanor Jing Yi Cheong,Evelyn Mei Ling Goh,Hooi Yan Moy,Annelies Cannaert,Christophe P Stove,Eric Chun Yong Chan. (2020-11-26) Diagnosing intake and rationalizing toxicities associated with 5F-MDMB-PINACA and 4F-MDMB-BINACA abuse.. Archives of toxicology, 95 ((2)): (489-508). [PMID:33236189] |
12. Changcheng Sun,Zhaoyang Yin,Ben-Zheng Li,Han Du,Keke Tang,Penglai Liu,Sio Hang Pun,Tim C Lei,Anan Li. (2021-02-14) Oxytocin modulates neural processing of mitral/tufted cells in the olfactory bulb.. Acta physiologica (Oxford, England), 231 ((4)): (e13626-e13626). [PMID:33580583] |
13. Abdullah Kutlar,Kenneth Ataga,Marvin Reid,Elliott P Vichinsky,Lynne Neumayr,Loray Blair-Britt,Richard Labotka,Jonathan Glass,Jeffrey R Keefer,William A Wargin,Ronald Berenson,Susan P Perrine. (2012-08-14) A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease.. American journal of hematology, 87 ((11)): (1017-1021). [PMID:22887019] |
14. Elise Wouters,Lukas Mogler,Annelies Cannaert,Volker Auwärter,Christophe Stove. (2019-04-26) Functional evaluation of carboxy metabolites of synthetic cannabinoid receptor agonists featuring scaffolds based on L-valine or L-tert-leucine.. Drug testing and analysis, 11 ((8)): (1183-1191). [PMID:31021521] |
15. Yukako Okazaki,Tetsuyuki Katayama. (2020-03-21) The effects of different high-fat (lard, soybean oil, corn oil or olive oil) diets supplemented with fructo-oligosaccharides on colonic alkaline phosphatase activity in rats.. European journal of nutrition, 60 ((1)): (89-99). [PMID:32193633] |
16. Bridgette Wilson,Megan Rossi,Tokuwa Kanno,Gareth C Parkes,Simon Anderson,A James Mason,Peter M Irving,Miranda C Lomer,Kevin Whelan. (2020-05-21) β-Galactooligosaccharide in Conjunction With Low FODMAP Diet Improves Irritable Bowel Syndrome Symptoms but Reduces Fecal Bifidobacteria.. The American journal of gastroenterology, 115 ((6)): (906-915). [PMID:32433273] |
17. Brandon C Presley,Marisol S Castaneto,Barry K Logan,Susan A Jansen-Varnum. (2020-07-28) Metabolic profiling of synthetic cannabinoid 5F-ADB and identification of metabolites in authentic human blood samples via human liver microsome incubation and ultra-high-performance liquid chromatography/high-resolution mass spectrometry.. Rapid communications in mass spectrometry : RCM, 34 ((22)): (e8908-e8908). [PMID:32710798] |
18. Ruoting Xu,Chuhong Tan,Yan He,Qiheng Wu,Huidi Wang,Jia Yin. (2020-09-26) Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Encephalitis: A Chinese Pilot Study.. Frontiers in immunology, 11 (1994-1994). [PMID:32973805] |