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2-[2-ethyl-3-oxamoyl-1-(phenylmethyl)benzo[g]indol-4-yl]oxyacetic acid , CAS No.E608677, Inhibitor of PLA 2-G5;Inhibitor of sPLA 2-10;Inhibitor of sPLA 2-1B;Inhibitor of sPLA 2-2A;Inhibitor of sPLA 2-2D;Inhibitor of sPLA 2-2E;Inhibitor of sPLA 2-2F

Item Number
E608677
Grouped product items
SKUSizeAvailabilityPrice Qty
E608677-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
E608677-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
PLA2-G5 Inhibitor sPLA2-10 Inhibitor sPLA2-1B Inhibitor sPLA2-2A Inhibitor sPLA2-2D Inhibitor sPLA2-2E Inhibitor sPLA2-2F Inhibitor

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of PLA 2-G5;Inhibitor of sPLA 2-10;Inhibitor of sPLA 2-1B;Inhibitor of sPLA 2-2A;Inhibitor of sPLA 2-2D;Inhibitor of sPLA 2-2E;Inhibitor of sPLA 2-2F

Associated Targets(Human)

PLA2G2D Tchem Group IID secretory phospholipase A2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G1B Tchem Phospholipase A2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G10 Tchem Group 10 secretory phospholipase A2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G2F Tchem Group IIF secretory phospholipase A2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G2A Tchem Phospholipase A2, membrane associated (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G5 Tchem Calcium-dependent phospholipase A2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G2E Tchem Group IIE secretory phospholipase A2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G2A Tchem Phospholipase A2 group IIA (1079 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G2E Tchem Group IIE secretory phospholipase A2 (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G10 Tchem Group X secretory phospholipase A2 (219 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G2F Tchem Group IIF secretory phospholipase A2 (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G2D Tchem Group IID secretory phospholipase A2 (24 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G5 Tchem Phospholipase A2 group V (238 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G3 Tbio Group III secretory phopholipase A2 (31 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

PLA2G1B Phospholipase A2 group 1B (227 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G2A Phospholipase A2, membrane associated (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[2-ethyl-3-oxamoyl-1-(phenylmethyl)benzo[g]indol-4-yl]oxyacetic acid
INCHI InChI=1S/C25H22N2O5/c1-2-18-21(24(30)25(26)31)22-19(32-14-20(28)29)12-16-10-6-7-11-17(16)23(22)27(18)13-15-8-4-3-5-9-15/h3-12H,2,13-14H2,1H3,(H2,26,31)(H,28,29)
InChi Key YLSSVFGTKZXLPA-UHFFFAOYSA-N
Canonical SMILES CCc1c(C(=O)C(=O)N)c2c(n1Cc1ccccc1)c1ccccc1cc2OCC(=O)O
Isomeric SMILES CCC1=C(C2=C(N1CC3=CC=CC=C3)C4=CC=CC=C4C=C2OCC(=O)O)C(=O)C(=O)N
PubChem CID 9867345

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Oslund RC, Cermak N, Gelb MH.  (2008)  Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2..  J Med Chem,  51  (15): (4708-14).  [PMID:18605714] [10.1021/op500134e]

Solution Calculators

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