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2-[3-[(3-chloro-4-methylphenyl)methoxy]azetidine-1-carbonyl]-7-oxa-5-azaspiro[3.4]octan-6-one , CAS No.C609260, Inhibitor of Monoacylglycerol lipase

Moligand™

PubChem CID: 130475870

Item Number

C609260

Grouped product items
SKU	Size	Availability	Price	Qty
C609260-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$376.90
C609260-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$897.90

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Monoacylglycerol lipase Inhibitor

Synonyms

compound 4f

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of Monoacylglycerol lipase

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR2 Tchem Cannabinoid receptor 2 0 Activities

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FAAH Tchem Fatty-acid amide hydrolase 1 0 Activities

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MGLL Tchem Monoglyceride lipase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABHD6 Tchem Monoacylglycerol lipase ABHD6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[3-[(3-chloro-4-methylphenyl)methoxy]azetidine-1-carbonyl]-7-oxa-5-azaspiro[3.4]octan-6-one
INCHI	InChI=1S/C18H21ClN2O4/c1-11-2-3-12(4-15(11)19)9-24-14-7-21(8-14)16(22)13-5-18(6-13)10-25-17(23)20-18/h2-4,13-14H,5-10H2,1H3,(H,20,23)/t13-,18+
InChi Key	AKBHYCHPWZPGAH-QGGXVJLZSA-N
Canonical SMILES	Cc1c(Cl)cc(COC2CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)cc1
Isomeric SMILES	CC1=C(C=C(C=C1)COC2CN(C2)C(=O)C3CC4(C3)COC(=O)N4)Cl
PubChem CID	130475870

PubChem CID

130475870

RCSB PDB Ligand

XOM

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
G2405390	Certificate of Analysis	Mar 18, 2024	C609260
G2405391	Certificate of Analysis	Mar 18, 2024	C609260
G2405392	Certificate of Analysis	Mar 18, 2024	C609260
G2405395	Certificate of Analysis	Mar 18, 2024	C609260

References

1. Ikeda S, Sugiyama H, Tokuhara H, Murakami M, Nakamura M, Oguro Y, Aida J, Morishita N, Sogabe S, Dougan DR et al.. (2021) Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety.. J Med Chem, 64 (15): (11014-11044). [PMID:34328319]

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