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2，3-Bis(4-hydroxyphenyl)propionitrile - ≥98%(HPLC), high purity , CAS No.1428-67-7, Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β
Specifications & Purity: ≥98%(HPLC)
Potent, selective ERβ agonist
Basic Description
| Synonyms | 1428-67-7|diarylpropionitrile|2,3-bis(4-hydroxyphenyl)propionitrile|2,3-bis(4-hydroxyphenyl)propanenitrile|2,3-bis(4-hydroxyphenyl)-propionitrile|2,3-Bis(p-hydroxyphenyl)propionitrile|52XWB8Q4V8|CHEMBL334773|C15H13NO2|CHEBI:63949|Benzenepropanenitrile,4-h |
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| Specifications & Purity | ≥98%(HPLC) |
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| Storage Temp | Store at -20°C |
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| Shipped In | Dry ice |
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| Action Type | AGONIST |
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| Mechanism of action | Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β |
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Names and Identifiers
| IUPAC Name | 2,3-bis(4-hydroxyphenyl)propanenitrile |
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| INCHI | InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2 |
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| InChi Key | GHZHWDWADLAOIQ-UHFFFAOYSA-N |
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| Canonical SMILES | C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O |
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| Isomeric SMILES | C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O |
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| WGK Germany | 3 |
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| PubChem CID | 102614 |
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| Molecular Weight | 239.27 |
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Chemical and Physical Properties
| Solubility | Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C). |
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| Sensitivity | Moisture & heat sensitive |
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| Melt Point(°C) | 200-204°C |
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Product Questions
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References
| 1. Waters EM, Mitterling K, Spencer JL, Mazid S, McEwen BS, Milner TA. (2009) Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus.. Brain Res, 1290 (3): (1-11). [PMID:19596275] |
| 2. Oh YS et al.. (2017) ESR1 inhibits hCG-induced steroidogenesis and proliferation of progenitor Leydig cells in mice.. Sci Rep, 7 (43459). [PMID:28266530] |
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