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2,3-Dichloro-1,4-naphthoquinone - 98%, high purity , CAS No.117-80-6

1 Citations

≥98%

CAS#: 117-80-6
Formula: C₁₀H₄Cl₂O₂
Molecular Weight: 227.04
Beilstein Registry Number: 1073511
EC Number: 204-210-5
MDL number: MFCD00001677
PubChem CID: 8342

Item Number

D109468

Grouped product items
SKU	Size	Availability	Price
D109468-25g	25g	In stock	$14.90
D109468-100g	100g	In stock	$51.90
D109468-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$85.90

View related series

ketone Non heterocyclic block

Basic Description

Synonyms	1,4-Naphthoquinone, 2,3-dichloro- \| 2,3-Dichlor-1,4-naftochinon \| 2,3-Dichloro-1,4-naphthoquinone, 98% \| 2,3-DICHLORO-1,4-NAPTHALENEDIONE \| FT-0609535 \| 2,3-Dichlor-1,4-naftochinon [Czech] \| CDS1_000275 \| WLN: L66 BV EVJ CG DG \| 2,3-dichloro-1,4-dihydrona
Specifications & Purity	≥98%
Storage Temp	Room temperature
Shipped In	Normal

Associated Targets(Human)

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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VDR Tclin Vitamin D receptor (26531 Activities)

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PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

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THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

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RXRA Tclin Retinoid X receptor alpha (3637 Activities)

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DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (978 Activities)

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AHR Tclin Aryl hydrocarbon receptor (1071 Activities)

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NR1H4 Tclin Bile acid receptor FXR (6228 Activities)

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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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MCF7 (126967 Activities)

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MOLT-3 (638 Activities)

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MRC5 (9203 Activities)

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SNB-19 (46794 Activities)

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A549 (127892 Activities)

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T47D (39041 Activities)

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HepG2 (196354 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)

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C32 (251 Activities)

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COLO-829 (166 Activities)

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Associated Targets(non-human)

Cruzipain (33337 Activities)

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Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

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gag Human immunodeficiency virus type 1 Gag protein (11 Activities)

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protease Human rhinovirus A protease (1343 Activities)

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Carbonic anhydrase (69 Activities)

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Aspergillus fumigatus (16427 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Candida parapsilosis (8521 Activities)

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Trypanosoma cruzi (99888 Activities)

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Trichoplusia ni (986 Activities)

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Mus musculus (284745 Activities)

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Sporothrix schenckii (1580 Activities)

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Vero (26788 Activities)

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rhodesain Rhodesain (1463 Activities)

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mtcA1 Uncharacterized protein Rv1284/MT1322 (182 Activities)

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Trichophyton mentagrophytes (4846 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)

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CELA2A Pancreatic elastase (395 Activities)

Discover Target: CELA2A

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2,3-dichloronaphthalene-1,4-dione
INCHI	InChI=1S/C10H4Cl2O2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H
InChi Key	SVPKNMBRVBMTLB-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=O)C(=C(C2=O)Cl)Cl
Isomeric SMILES	C1=CC=C2C(=C1)C(=O)C(=C(C2=O)Cl)Cl
WGK Germany	3
RTECS	QL7525000
PubChem CID	8342
UN Number	2902
Packing Group	I
Molecular Weight	227.04
Beilstein	1073511

Certificates

Certificate of Analysis(COA)

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9 results found

Lot Number	Certificate Type	Date	Item
G1531016	Certificate of Analysis	Mar 08, 2023	D109468
F23161072	Certificate of Analysis	Aug 01, 2022	D109468
F23161079	Certificate of Analysis	Aug 01, 2022	D109468
F2404012	Certificate of Analysis	Aug 01, 2022	D109468
H2308266	Certificate of Analysis	Aug 01, 2022	D109468
I2209410	Certificate of Analysis	Aug 01, 2022	D109468
I2209411	Certificate of Analysis	Aug 01, 2022	D109468
I2209412	Certificate of Analysis	Aug 01, 2022	D109468
I2405074	Certificate of Analysis	Aug 01, 2022	D109468

Chemical and Physical Properties

Solubility	Soluble in water (0.008g/L). Soluble in hot toluene almost transparency
Boil Point(°C)	275°C
Melt Point(°C)	194-197°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	3
RTECS	QL7525000
Class	6.1
Merck Index	3045

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639]

References

1. R M Vos,B Van Ommen,M S Hoekstein,J H De Goede,P J Van Bladeren. (1989-01-01) Irreversible inhibition of rat hepatic glutathione S-transferase isoenzymes by a series of structurally related quinones.. Chemico-biological interactions, 71 ((4)): (381-392). [PMID:2582541]
2. A J Elliott,R S Pardini. (1988-08-01) Modulation of hepatic cytochrome P-450 and DT-diaphorase by oral and sub-cutaneous administration of the pro-oxidant fungicide dichlone (2,3-dichloro-1,4-naphthoquinone).. Bulletin of environmental contamination and toxicology, 41 ((2)): (164-171). [PMID:3145044]
3. C A Pritsos,L M Aaronson,R S Pardini. (1986-04-01) Metabolic consequences of dietary 2,3-dichloro-1,4-naphthoquinone (CNQ) in the rat. Alteration in anti-oxidant enzyme activities.. Biochemical pharmacology, 35 ((7)): (1131-1135). [PMID:3964293]
4. C A Pritsos,D E Jensen,D Pisani,R S Pardini. (1982-08-01) Involvement of superoxide in the interaction of 2,3-dichloro-1,4-naphthoquinone with mitochondrial membranes.. Archives of biochemistry and biophysics, 217 ((1)): (98-109). [PMID:6289757]
5. S Ahmad,K Zaman,R S MacGill,J P Batcabe,R S Pardini. (1995-11-01) Dichlone-induced oxidative stress in a model insect species, Spodoptera eridania.. Archives of environmental contamination and toxicology, 29 ((4)): (442-448). [PMID:7574883]
6. H J Kallmayer,B Thierfelder. (2002-10-09) [Reactions of trialkylamine compounds with 2,3-dichloro-1,4-naphthoquinone].. Die Pharmazie, 57 ((9)): (648-649). [PMID:12369457]
7. Ibrahim A Darwish. (2005-03-12) Development and validation of spectrophotometric methods for determination of fluoxetine, sertraline, and paroxetine in pharmaceutical dosage forms.. Journal of AOAC International, 88 ((1)): (38-45). [PMID:15759724]
8. Cláudia Valente,Rui Moreira,Rita C Guedes,Jim Iley,Mohammed Jaffar,Kenneth T Douglas. (2007-05-29) The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.. Bioorganic & medicinal chemistry, 15 ((15)): (5340-5350). [PMID:17532221]
9. Sanjeev Kumar,William P Malachowski,James B DuHadaway,Judith M LaLonde,Patrick J Carroll,Daniel Jaller,Richard Metz,George C Prendergast,Alexander J Muller. (2008-03-06) Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.. Journal of medicinal chemistry, 51 ((6)): (1706-1718). [PMID:18318466]
10. Avijit Saha,Amit S Tiwary,Asok K Mukherjee. (2008-03-18) Charge transfer interaction of 4-acetamidophenol (paracetamol) with 2,3-dichloro-1,4-naphthoquinone: a study in aqueous ethanol medium by UV-vis spectroscopic and DFT methods.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71 ((3)): (835-840). [PMID:18343717]
11. Vishnu K Tandon,Hardesh K Maurya,Ashutosh Tripathi,G B ShivaKeshava,Praveen K Shukla,Pallavi Srivastava,Dulal Panda. (2008-08-19) 2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.. European journal of medicinal chemistry, 44 ((3)): (1086-1092). [PMID:18708272]
12. Christophe Morisseau,Oleg Merzlikin,Amy Lin,Guochun He,Wei Feng,Isela Padilla,Michael S Denison,Isaac N Pessah,Bruce D Hammock. (2010-01-06) Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors.. Environmental health perspectives, 117 ((12)): (1867-1872). [PMID:20049205]
13. Pamela P Vaughan,Paul Novotny,Nicole Haubrich,Luther McDonald,Michael Cochran,Julia Serdula,Raid W Amin,Wade H Jeffrey. (2010-10-07) Bacterial growth response to photoactive quinones.. Photochemistry and photobiology, 86 ((6)): (1327-1333). [PMID:20923439]
14. S Ohta,S Hatakeyama,C Aono,T Koike,I Tanimizu,H Hirakawa. (1992-08-01) [Preparation of water-soluble hydronaphthoquinone derivatives and its application to the determination of hydrogen peroxide in clinical chemistry].. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 112 ((8)): (585-591). [PMID:1432607]
15. C A Pritsos,D E Pisani,R S Pardini. (1985-07-01) Inhibition of liver glycolysis in rats by dietary dichlone (2,3-dichloro-1,4-naphthoquinone).. Bulletin of environmental contamination and toxicology, 35 ((1)): (23-28). [PMID:4027405]
16. C A Pritsos,R S Pardini. (1983-11-01) A role for glutathione disulfide as a scavenger of oxygen radicals produced by 2,3-dichloro-1,4-naphthoquinone.. Research communications in chemical pathology and pharmacology, 42 ((2)): (271-280). [PMID:6318284]
17. C A Pritsos,R S Pardini. (1984-12-01) A redox cycling mechanism of action for 2,3-dichloro-1,4-naphthoquinone with mitochondrial membranes and the role of sulfhydryl groups.. Biochemical pharmacology, 33 ((23)): (3771-3777). [PMID:6508833]
18. N Gallo,P Bianco,R Tapino,G Luisi. (1983-04-14) [Interaction of methimazole and quinones. Spectrophotometric determination of methimazole in blood].. Minerva medica, 74 ((16)): (875-877). [PMID:6843873]
19. M Alnabari,S Bittner. (2001-07-17) New quinone-amino acid conjugates linked via a vinylic spacer.. Amino acids, 20 ((4)): (381-387). [PMID:11452981]
20. H J Kallmayer,B Thierfelder. (2002-09-14) [Reactions between dialkylamine drugs, 2,3-dichloro-1,4-naphthoquinone and acetaldehyde].. Die Pharmazie, 57 ((8)): (530-534). [PMID:12227191]
21. H J Kallmayer,B Thierfelder. (2003-03-19) [Reactions of isopropyl-alkylamine with 2,3-dichloro-1,4-naphthoquinone and 2,3-dichloro-1,4-naphthoquinone/acetaldehyde].. Die Pharmazie, 58 ((2)): (104-107). [PMID:12641324]
22. Gururaj M Neelgund,M L Budni. (2005-05-03) Interaction of 2,3-dichloro-1,4-naphthoquinone with n-butylamine in halocarbon solvents.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 61 ((8)): (1729-1735). [PMID:15863041]
23. Sam Mula,Anton Savitsky,Klaus Möbius,Wolfgang Lubitz,John H Golbeck,Mahir D Mamedov,Alexey Yu Semenov,Art van der Est. (2012-01-17) Incorporation of a high potential quinone reveals that electron transfer in Photosystem I becomes highly asymmetric at low temperature.. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11 ((6)): (946-956). [PMID:22246442]
24. Angupillai Satheshkumar,Kuppanagounder P Elango. (2012-09-18) Spectroscopic and theoretical studies on the nucleophilic substitution of 2,3-dichloronaphthoquinone with para-substituted anilines in solid state via initial charge transfer complexation.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 98 (378-383). [PMID:22981514]
25. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639]

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2,3-Dichloro-1,4-naphthoquinone - 98%, high purity , CAS No.117-80-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

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