2′,3′-Dideoxy-3′-fluorouridine - 95%, high purity , CAS No.41107-56-6

  • ≥95%
Item Number
D357191
Grouped product items
SKUSizeAvailabilityPrice Qty
D357191-5mg
5mg
In stock
$157.90
D357191-25mg
25mg
In stock
$546.90
D357191-100mg
100mg
In stock
$1,531.90

an anti-retroviral compound

Basic Description

Synonyms2',3'-Dideoxy-3'-fluorouridine | 41107-56-6 | Fddurd | 3'-Fluoro-2',3'-dideoxyuridine | 3'-FddU | 207128-22-1 | 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4
Specifications & Purity≥95%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

2′,3′-Dideoxy-3′-fluorouridine exhibits anti-retrovirus activity.


Product Introduction

2′,3′-Dideoxy-3′-fluorouridine (3′-fluoro-2′,3′-dideoxyuridine, FddUrd) is a fluorinated pyrimidine nucleoside analog of uridine. It has been studied extensively for its potential use as an antiviral agent against HIV.


Application

2′,3′-Dideoxy-3′-fluorouridine can be used as a starting material in the synthesis of:

3′-fluoro 2′,3′-dideoxynucleoside analogs for in vitro antiviral activity studies.

3′-fluoro deoxyuridine monophosphate analogs as potential anti parasites.

Associated Targets(Human)

DUT Tchem Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MT4 (17854 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DUT Tchem dUTP pyrophosphatase (446 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei rhodesiense (7991 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L6 (7924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
INCHI InChI=1S/C9H11FN2O4/c10-5-3-8(16-6(5)4-13)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4H2,(H,11,14,15)/t5-,6+,8+/m0/s1
InChi Key BKIUEHLYJFLWPK-SHYZEUOFSA-N
Canonical SMILES C1C(C(OC1N2C=CC(=O)NC2=O)CO)F
Isomeric SMILES C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)F
WGK Germany 1
PubChem CID 162450
Molecular Weight 230.19

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
G2208374Certificate of AnalysisJun 02, 2022 D357191
G2208375Certificate of AnalysisJun 02, 2022 D357191
G2208378Certificate of AnalysisJun 02, 2022 D357191

Chemical and Physical Properties

Boil Point(°C)480.84° C (Predicted)
Melt Point(°C)184-188° C (lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements

H341:Suspected of causing genetic defects

Precautionary Statements

P405:Store locked up.

P501:Dispose of contents/container to ...

P281:Use personal protective equipment as required.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

WGK Germany 1
RIDADR NONHforallmodesoftransport

Related Documents

Solution Calculators