2′,3′-Dideoxycytidine - 99%, high purity , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.7481-89-2, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Item Number

D119514

• Synonyms: 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one | Hivid (TN) | bmse000712 | CCG-101050 | CS-1110 | HMS2051H18 | NCGC00090705-08 | SCHEMBL3598 | SMR000058253 | Tox21_201655 | BDBM50145605 | Zalcitabine (JAN/USP/INN) | HMS3715O15 |
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NARTI). Zalcitabine is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Zalcitabine is phosphory
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Application

2',3'-Dideoxycytidine in cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM). It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered. It is also is used as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination method.